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Ampicillin pharmaceutical composition and anti-tumor effect thereof

A technology of ampicillin and composition, which is applied in the field of ampicillin pharmaceutical composition, can solve problems such as easy drug resistance, and achieve the effect of improving anti-tumor

Inactive Publication Date: 2016-06-15
李晨露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among Gram-negative bacteria, Neisseria gonorrhoeae, meningococcus, influenza bacillus, pertussis bacillus, Escherichia coli, typhoid paratyphoid bacillus, Shigella bacillus, Proteus mirabilis, Brucella, etc. are sensitive to this product, but are prone to drug resistance

Method used

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  • Ampicillin pharmaceutical composition and anti-tumor effect thereof
  • Ampicillin pharmaceutical composition and anti-tumor effect thereof
  • Ampicillin pharmaceutical composition and anti-tumor effect thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0017] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0018] Separation method: (a) crush the dried coltsfoot flower (2kg), extract with 80% ethanol under heat reflux, combine the extracts, concentrate until there is no alcohol smell, and extract with petroleum ether, ethyl acetate and water-saturated n-butanol in sequence , obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; volume, then eluted 12 column volumes with 75% ethanol, collected 75% eluent, concentrated under reduced pressure to obtain 75% ethanol eluted concentrate; (c) 75% ethanol eluted concentrate in step (b) with normal Phase silica gel separation, followed by the volum...

Embodiment 2

[0021] Embodiment 2: pharmacological action

[0022] 1. Materials and methods

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PUM

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Abstract

The invention discloses a pharmaceutical composition of ampicillin and its antitumor effect. The pharmaceutical composition of ampicillin provided by the invention contains ampicillin and a natural product compound with a novel structure isolated from dried coltsfoot flowers (I), when ampicillin and the natural product compound (I) act alone, the anti-tumor effect is general; when the two act in combination, the anti-tumor effect is significantly improved, and can be developed into an anti-tumor drug, which has the advantages compared with the prior art Outstanding substantive features and notable advancements.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of ampicillin, in particular to a pharmaceutical composition of ampicillin and its antitumor medical application. Background technique [0002] Ampicillin is a semi-synthetic broad-spectrum penicillin, its free acid contains 3 molecules of crystal water, for oral use; its sodium salt is for injection. The effect on Gram-positive bacteria is similar to that of penicillin G, the effect on Streptococcus viridans and Enterococcus is better, and the effect on other bacteria is poor. Ineffective against penicillin G-resistant Staphylococcus aureus. Among Gram-negative bacteria, Neisseria gonorrhoeae, meningococcus, influenza bacillus, pertussis bacillus, Escherichia coli, typhoid paratyphoid bacillus, Shigella bacillus, Proteus mirabilis, Brucella, etc. are sensitive to this product, but are prone to drug resistance. Klebsiella pneumoniae, indole-positive Proteus, and Pseudo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/757C07C45/78C07C45/79A61K31/122A61K31/43A61P35/00
CPCC07C49/757A61K31/122A61K31/43C07C45/78C07C45/79
Inventor 李晨露
Owner 李晨露
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