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Preparation method of compound clobetasol propionate liniment

A technology of compound chlorine propionate and film agent, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, anti-inflammatory agents, etc. In order to achieve the effect of promoting drug transdermal absorption, good therapeutic effect, and enhancing antipruritic and keratolytic effects

Inactive Publication Date: 2016-06-22
CHENGDU AIBIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its compound can treat a variety of skin diseases, such as neurodermatitis, eczema, psoriasis, etc. Currently, the dosage forms on the domestic market include injections, tablets, and capsules, and the existing gels, eye drops, ear drops, and suppositories, etc. , but have not yet seen the preparation of the compound clobetasol propionate film

Method used

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Examples

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Embodiment

[0018] The compound clobetasol propionate coating agent of the present embodiment is expressed in parts by weight, mainly consisting of 0.5g clobetasol propionate, 50g salicylic acid, 10ml peppermint oil, 70g polyvinyl alcohol, 1g paraben Esters, 400ml mass fraction of 80% ethanol solution, and a sufficient amount of purified water.

[0019] In this embodiment, clobetasol propionate and salicylic acid are mainly used as main agents, polyvinyl alcohol is used as a film-forming material, and propylene glycol and peppermint oil are used as penetration enhancers.

[0020] Clobetasol propionate is an adrenocortical hormone drug with strong anti-inflammatory, anti-pruritic and vasoconstrictive effects, and is used to treat skin inflammation and pruritus. Salicylic acid is a commonly used disinfectant and antiseptic drug in dermatology. It is cheap but highly practical. According to its concentration, it can inhibit the growth of bacteria and fungi, relieve itching, and dissolve cuti...

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PUM

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Abstract

The invention discloses a preparation method of a compound clobetasol propionate liniment. The method comprises the steps that 1, propylene glycol is added to purified water to be stirred; 2, polyvinyl alcohol is completely soaked in mixed liquor in the first step, heating is conducted, and polyvinyl alcohol is completely dissolved; 3, clobetasol propionate and salicylic acid are weighed, peppermint oil is added, stirring is conducted, and the mixed liquor is added simultaneously; 4, ethylparaben is added and stirred simultaneously, after ethylparaben is completely dissolved, a sufficient amount of the purified water is added, and the liniment is obtained. After the liniment is smeared on the skin to form a film, hydration is produced to promote drug percutaneous absorption, the effects of relieving itching and dissolving cutin are improved, the liniment is used for topical therapies of prurigo nodularis, cutin thickening skin diseases, dermatitis and eczema, use is convenient and safe, and the therapeutic effect is good.

Description

technical field [0001] The invention relates to the technical field of coating agent preparation, in particular to a method for preparing a compound clobetasol propionate coating agent. Background technique [0002] The compound clobetasol propionate is an adrenocorticotropic hormone drug, which has strong anti-inflammatory and anti-allergic effects and is relatively long-lasting. External skin preparations are suitable for various skin diseases. Salicylic acid is a commonly used disinfectant and antiseptic in dermatology. It is cheap However, it has strong practicability, and it can inhibit the growth of bacteria and fungi, relieve itching, and dissolve cuticles according to the concentration of its use. Its compound can treat a variety of skin diseases, such as neurodermatitis, eczema, psoriasis, etc. Currently, the dosage forms on the domestic market include injections, tablets, and capsules, and the existing gels, eye drops, ear drops, and suppositories, etc. , but have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/60A61K47/10A61K47/32A61K47/46A61P29/00A61P37/08A61P17/00A61P17/06
CPCA61K9/7015A61K31/573A61K31/60A61K47/10A61K47/32A61K47/46A61K2300/00
Inventor 何金蓉
Owner CHENGDU AIBIKE BIOTECH
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