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A modified gelatin hemostatic material and preparation method thereof

A hemostatic material, gelatin technology, applied in the medical field, can solve problems such as high swelling rate, easy to compress nerves, and patient discomfort, and achieve the effect of small swelling rate, good fluidity, and low content of cross-linking agent

Active Publication Date: 2021-04-16
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing gelatin-based hemostatic materials have a high swelling rate, and there are many nerves in some narrow parts, such as tumor cavity, nasal cavity, brain dura mater, and spinal venous plexus. could even have serious consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] S1. Dissolve 10g of gelatin in 90g of pure water to prepare a gelatin solution with a concentration of 10%, and suspend for 1 hour to fully swell the gelatin;

[0037] S2. Add glutaraldehyde cross-linking agent, the amount of glutaraldehyde added accounts for 0.01% of the gelatin mass;

[0038] S3. Treat the solution with a microwave with a power of 150W for 20 minutes;

[0039] S4. Use non-woven fabric to filter, remove solvent, obtain modified gelatin;

[0040] S5. Rinse 3 times with clean water and 3 times with ethanol in turn, and then wash the modified gelatin with clean water to remove unreacted crosslinking agent;

[0041] S6. Pre-freeze the cleaned modified gelatin in a -20°C refrigerator for 20 hours to solidify;

[0042] S7. Drying with a low-temperature and low-pressure freeze dryer for 24 hours to obtain sheet-shaped modified gelatin;

[0043] S8. Grinding or pulverizing to obtain a powdery gelatin hemostatic material.

Embodiment 2

[0045] S1. Dissolve 5g of gelatin in 95g of pure water to prepare a gelatin solution with a concentration of 5%, and suspend for 1 hour to fully swell the gelatin;

[0046] S2. Add glutaraldehyde cross-linking agent, the amount of glutaraldehyde added accounts for 0.05% of the gelatin mass;

[0047] S3. Treat the solution with a microwave with a power of 400W for 15 minutes;

[0048] S4. Use non-woven fabric to filter, remove solvent, obtain modified gelatin;

[0049] S5. Rinse 4 times with water and 2 times with ethanol in turn, and then wash the modified gelatin with water to remove unreacted crosslinking agent;

[0050] S6. Place the cleaned modified gelatin in liquid nitrogen for pre-freezing to make it solidify, filter block frozen matter, grind, and add liquid nitrogen at the same time to prevent the frozen matter from melting;

[0051] S7. Drying with a low-temperature and low-pressure freeze dryer for 24 hours to obtain sheet-shaped modified gelatin;

[0052] S8. Gr...

Embodiment 3

[0054] S1. Dissolve 10g of gelatin in 90g of pure water to prepare a gelatin solution with a concentration of 10%, and suspend for 1 hour to fully swell the gelatin;

[0055] S2. Add glutaraldehyde cross-linking agent, the amount of glutaraldehyde added accounts for 0.001% of the gelatin mass;

[0056] S3. process the solution with a microwave with a power of 600W for 30 minutes;

[0057] S4. Use non-woven fabric to filter, remove solvent, obtain modified gelatin;

[0058] S5. Rinse 5 times with clear water and 3 times with ethanol in sequence, and then wash the modified gelatin with clear water to remove unreacted crosslinking agent;

[0059] S6. Pre-freeze the cleaned modified gelatin in a -20°C refrigerator for 4 hours to solidify;

[0060] S7. Dry for 48 hours with a low-temperature and low-pressure freeze dryer to obtain sheet-shaped modified gelatin;

[0061] S8. Grinding or pulverizing to obtain a powdery gelatin hemostatic material.

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Abstract

The invention discloses a modified gelatin hemostatic material and a preparation method thereof. The preparation method of the modified gelatin hemostatic material comprises the following steps: after the gelatin is made into a gelatin solution, an aldehyde cross-linking agent of 0.001% to 0.05% relative to the gelatin content is added, and then treated under a microwave with a power of 100 to 600W for 15 ~45min, then wash and dry. The gelatin hemostatic material prepared by the above method has a small swelling rate and can be used for the treatment of small wounds; and the content of the aldehyde crosslinking agent is low, which has better safety than the existing gelatin products.

Description

technical field [0001] The invention relates to the medical field, in particular, the invention relates to a modified gelatin material with hemostatic effect. Background technique [0002] Gelatin has good biocompatibility, biodegradability and bioactivity, and has extremely wide applications in the field of biomedicine. However, uncrosslinked gelatin is easily soluble in water and easily degraded in the body, and its dry product is brittle in texture, poor in mechanical strength, and high in swelling degree. Therefore, in practical applications, certain methods are often used to make them cross-linked and modified to meet the performance requirements of the application. [0003] Bleeding is the most common situation encountered in surgical operations. The existing hemostatic products are mainly in the form of lumps or lumps, such as sponges, gauze, dressings, etc., which are not suitable for uneven or small wounds, because hemostatic The product does not form a good fit w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00
CPCA61L24/001A61L24/104A61L2400/04
Inventor 林丽敏邓坤学杨亚亚袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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