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Magnetic molecular imprinting electrochemical sensor for detecting trace sulfadimidine

A magnetic molecular imprinting and sulfamethazine technology, which is applied in the direction of material electrochemical variables, can solve the problems of no relevant research on the detection of trace sulfamethazine, and achieve the effect of improving sensitivity and selectivity and being easy to automate

Active Publication Date: 2016-06-22
ZHAOQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Combining magnetic molecular imprinting technology with sensors can obtain high-sensitivity and high-selectivity biosensors. There have been related reports, but there is no relevant research on the detection of trace amounts of sulfamethazine.

Method used

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  • Magnetic molecular imprinting electrochemical sensor for detecting trace sulfadimidine
  • Magnetic molecular imprinting electrochemical sensor for detecting trace sulfadimidine
  • Magnetic molecular imprinting electrochemical sensor for detecting trace sulfadimidine

Examples

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Embodiment 1

[0022] Embodiment 1: The construction of the magnetic molecularly imprinted electrochemical sensor for detecting trace amounts of sulfamethazine according to the present invention is characterized in that the magnetic molecularly imprinted electrochemical sensor is prepared by the following method:

[0023] (1) Processing of magnetic core electrodes:

[0024] Put the magnetic core glassy carbon electrode in 0.2M sulfuric acid to activate for 20min, then use 1.0, 0.3 and 0.05μm α-alumina powder to polish the surface, rinse it with ultrapure water and dry it, then put the electrode on the K at 5mM 3 [Fe(CN) 6 ] solution, a cyclic voltammetry (CV) scan was performed at a rate of 100 mV / s in the potential range of -0.2V to 0.6V until a stable cyclic voltammetry was obtained.

[0025] (2) Modification of core electrodes:

[0026] Weigh 10 mg magnetically reduced graphene Fe 3 o 4 rGO was ultrasonically dispersed in 4 mL of water for 10 min to form a dispersion. Use a micropip...

Embodiment 2

[0031] Example 2: Cyclic voltammetry characterization of the magnetic molecularly imprinted electrochemical sensor for detecting trace amounts of sulfamethazine according to the present invention

[0032] Since the imprinted holes in the membrane can serve as channels for electron transfer, using K 3 [Fe(CN) 6 ] as a probe, according to the magnitude of its current to characterize the surface properties of various electrodes. Such as figure 1 shown, different electrodes at 5mM K 3 [Fe(CN) 6 ] The cyclic voltammograms in the solution are significantly different. Curve a is the cyclic voltammogram of the bare magnetic core electrode, and the redox peak is obvious. As shown in curve b, when a layer of Fe is modified on the surface of the magnetic glassy carbon electrode 3 o 4 After the rGO composite, the peak current increases significantly, which is due to the Fe 3 o 4 The rGO composite has good conductivity, which can promote electron transfer on the electrode surface ...

Embodiment 3

[0033] Example 3: Scanning electron microscopy characterization of different modified electrodes for magnetic molecular imprinting electrochemical sensing of the present invention for detecting trace amounts of sulfamethazine

[0034] The microstructure of different modified electrodes was characterized by scanning electron microscopy. Such as Figure 2a As shown, the electrode surface is smooth after the molecular imprinted membrane is modified on the surface of the electrode, indicating that the imprinting effect is good; rough (see Figure 2b ).

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Abstract

The invention relates to a magnetic molecular imprinting electrochemical sensor for detecting trace sulfadimidine. The magnetic molecular imprinting electrochemical sensor of sulfadimidine is prepared by adopting a magnetic reduced graphene modified magnetic electrode and applying dopamine to carry out self-polymerization. When the concentration of olaquindox is in a range of 10.0nM-200.0nM, an electrochemical signal rising degree has a good linear relation with the concentration of sulfadimidine; and the detection limit of a method reaches 0.1nM. When the sensor is used for detecting an actual sample, the yield reaches 92.6%-101.7%; and with the adoption of the magnetic molecular imprinting electrochemical sensor, the sensitivity and selectivity of sulfadimidine are improved, and the automation of detection of trace sulfadimidine is easy to realize.

Description

technical field [0001] The invention belongs to the technical field of novel functional materials and electrochemical sensing and detection, and relates to a magnetic molecular imprinted electrochemical sensor, in particular to a magnetic molecular imprinted electrochemical sensor for detecting trace amounts of sulfamethazine. Background technique [0002] Sulfamethazine (Sulfadimidine, SM2), also known as sulfamethazine and methadrimidine, is systematically named N-(4,6-dimethyl-2-pyrimidinyl)-4-aminobenzenesulfonamide. Sulfamethazine, sulfa drugs are a class of broad-spectrum antibacterial drugs, widely used in the prevention and treatment of animal diseases, especially livestock and poultry diseases. However, excessive intake of sulfamethazine by the human body affects the immune system and urinary system of the human body, destroys the ecological balance of the normal flora of the body, and leads to drug resistance of pathogenic bacteria. Therefore, the detection and co...

Claims

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Application Information

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IPC IPC(8): G01N27/48
CPCG01N27/48
Inventor 汪洪武刘艳清姚夙严子军余健健
Owner ZHAOQING UNIV
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