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Ganoderma lucidum polysaccharide compound for treating hand, foot and mouth disease and preparation method thereof

A technology of Ganoderma lucidum polysaccharide and hand, foot and mouth disease, which is applied in the field of Ganoderma lucidum polysaccharide complex for the treatment of hand, foot and mouth disease and its preparation field, and can solve the research and patent of the Ganoderma lucidum polysaccharide complex for preventing and treating hand, foot and mouth disease and anti-enterovirus type 71, etc. problem, to achieve the effect of strong resistance to enterovirus 71, simple process operation, low cost and price

Active Publication Date: 2019-08-13
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patents of Ganoderma lucidum anti-enterovirus 71 are mainly concentrated on ganoderma acid, and there are no researches and patents on the prevention and treatment of hand, foot and mouth disease and anti-enterovirus 71 of Ganoderma lucidum polysaccharide complex

Method used

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  • Ganoderma lucidum polysaccharide compound for treating hand, foot and mouth disease and preparation method thereof

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Embodiment 1

[0033] A Ganoderma lucidum polysaccharide compound for treating hand, foot and mouth disease, which consists of the following components in parts by weight: 20 parts of Ganoderma lucidum polysaccharide, 3 parts of compound Chinese medicine extracts of Houttuynia cordata, Forsythia, Anemarrhena, 5 parts of sucrose, and 0.03 parts of aspartame parts, 0.03 parts of essence, and 200 parts of purified water.

[0034] The preparation method of described Ganoderma lucidum polysaccharide is:

[0035] (1) Ganoderma lucidum fruiting bodies were washed twice, dried at 55°C, ultrafinely pulverized, passed through an 80-mesh sieve, and set aside;

[0036] (2) Add 95% ethanol to the Ganoderma lucidum powder prepared in step (1) at a weight-to-volume ratio of g / mL of 1:3, reflux at 65°C for 1 hour to remove fat-soluble substances, centrifuge at 3000 r / min for 10 minutes, and collect the filter residue , dried at 50°C, superfinely pulverized and passed through an 80-mesh sieve, and set aside...

Embodiment 2

[0056] A Ganoderma lucidum polysaccharide compound for treating hand, foot and mouth disease, which consists of the following components in parts by weight: 30 parts of Ganoderma lucidum polysaccharide, 4 parts of compound Chinese medicine extracts of Houttuynia cordata, Forsythia, Anemarrhena, 10 parts of sucrose, and 0.05 parts of aspartame parts, 0.08 parts of essence, and 300 parts of purified water.

[0057] The preparation method of described Ganoderma lucidum polysaccharide is:

[0058] (1) Ganoderma lucidum fruiting bodies were washed 3 times, dried at 60°C, ultrafinely pulverized, passed through a 100-mesh sieve, and set aside;

[0059] (2) Add 95% ethanol to the Ganoderma lucidum powder prepared in step (1) at a weight-to-volume ratio of g / mL of 1:4, reflux at 80°C for 2 hours to remove fat-soluble substances, centrifuge at 4500 r / min for 15 minutes, and collect The filter residue was dried at 60°C, ultrafinely pulverized and passed through a 100-mesh sieve, and set...

Embodiment 3

[0079] A ganoderma polysaccharide compound for treating hand, foot and mouth disease, which consists of the following components in parts by weight: 25 parts of ganoderma polysaccharide, 5 parts of compound Chinese medicine extracts of Houttuynia cordata, forsythia, and anemarrhena, 7 parts of sucrose, and 0.04 parts of aspartame parts, 0.05 parts of essence, and 250 parts of purified water.

[0080] The preparation method of described Ganoderma lucidum polysaccharide is:

[0081] (1) Ganoderma lucidum fruiting bodies were washed 3 times, dried at 60°C, ultrafinely pulverized, passed through a 100-mesh sieve, and set aside;

[0082] (2) Add 95% ethanol to the Ganoderma lucidum powder prepared in step (1) at a weight-to-volume ratio of g / mL of 1:4, reflux at 70°C for 2 hours to remove fat-soluble substances, centrifuge at 4000 r / min for 12 minutes, and collect The filter residue was dried at 55°C, ultrafinely pulverized and passed through an 80-mesh sieve, and set aside;

[0...

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Abstract

The invention relates to a ganoderan complex for treating the hand-foot-and-mouth disease and a preparation method of the ganoderan complex and belongs to the technical field of medicinal health-care food. The ganoderan complex is prepared from components in parts by weight as follows: 20-30 parts of ganoderan, 3-5 parts of a heartleaf houttuynia herb, weeping forsythiae capsule and common anemarrhena rhizome composite traditional Chinese medicine extract, 5-10 parts of saccharose, 0.03-0.05 parts of aspartame, 0.03-0.08 parts of essence and 200-300 parts of pure water. Fat-soluble impurities in lucid ganoderma are removed through ethanol reflux, then the lucid ganoderma is extracted with hot water, precipitated through ethanol and subjected to column chromatographic purification, ganoderan is obtained and compounded with the prepared heartleaf houttuynia herb, weeping forsythiae capsule and common anemarrhena rhizome composite traditional Chinese medicine extract, and the genoderan complex is prepared. Tests indicate that the complex has a remarkable inhibition effect on human enterovirus 71.

Description

technical field [0001] The invention relates to the technical field of medicine and health food, in particular to a ganoderma polysaccharide compound for treating hand-foot-mouth disease and a preparation method thereof. Background technique [0002] Hand, foot and mouth disease usually occurs in children under 3 years old, accompanied by prodromal symptoms such as low fever, abdominal pain, and general malaise. Painful blisters will appear in the mouth, pharynx, and soft palate. Clinical manifestations such as inflammation and encephalomyelitis. Enterovirus 71 is one of the main pathogens causing hand, foot and mouth disease in infants and young children. So far, there is no very effective treatment plan clinically. [0003] Ganoderma lucidum is a precious medicinal fungus, which has the effects of enhancing immunity, anti-tumor, and anti-aging. Ganoderma acid is a triterpenoid compound extracted from Ganoderma lucidum, which has been reported in anti-inflammatory, anti-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/8964A61K9/08A61P31/14
CPCA61K9/08A61K31/715A61K36/634A61K36/78A61K36/8964A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 赵超刘斌陈玉青
Owner FUJIAN AGRI & FORESTRY UNIV