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Anti-infection covering bag and preparation method thereof

An anti-infection and coating technology, applied in the manufacture of rayon, one-component polyester rayon, one-component polyurethane rayon, etc. The uniformity of the drug effect of the woven mesh, the uneven distribution of the coating material, etc., to achieve the effect of good adhesion, large specific surface area of ​​the fiber, and uniform mechanical properties

Active Publication Date: 2016-06-29
ACCUPATH MEDICAL JIAXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] U.S. Patent No. 8,591,531B2 discloses a covering bag for a cardiac implant device, which is made of a commercial polypropylene patch through ultrasonic heat fusion. uniform
The coating bag described in the Chinese patent CN101332311B is coated with degradable materials and drugs on the surface of the polypropylene woven mesh by dipping the coating method. This coating method may cause uneven distribution of the coating material on the surface of the woven mesh, thereby affecting The uniformity of drug efficacy of the drug-loaded woven net
[0004] It can be seen from the above that the existing cardiac implant device coating bags have the disadvantage of uneven structure due to the need for subsequent fusion and suturing, and the drug needs to be added to the surface of the coating bag by coating, which affects the drug sustained release process and Uniformity of efficacy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • Anti-infection covering bag and preparation method thereof
  • Anti-infection covering bag and preparation method thereof
  • Anti-infection covering bag and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Using hexafluoroisopropanol solution as a solvent, a 7wt% chitosan solution was prepared, wherein 200 μg / mL aspirin was dissolved in the chitosan solution. Electrospinning is used for spinning, the receiving voltage of the three-dimensional receiver is 16kV, and the receiving distance is 16cm. The receiver is shaped like Figure 2-5 shown.

Embodiment 2

[0048] The inner channel of the coaxial electrospinning nozzle is filled with hexafluoroisopropanol solution as a solvent to prepare a 15wt% polyester solution, and the outer channel of the coaxial electrospinning nozzle is filled with hexafluoroisopropanol The solution is a solvent, and a 7wt% chitosan solution is prepared, wherein 200 μg / mL aspirin is dissolved in the chitosan solution. Coaxial electrospinning is used for spinning, the receiving voltage of the three-dimensional receiver is 16kV, and the receiving distance is 16cm. During the spinning process, the polyester solution is sprayed out from the inner channel of the coaxial spinneret to form a core structure in the "skin-core" structure, and the chitosan solution is sprayed out from the outer channel of the coaxial spinneret to form a "skin-core" structure. The cortical structure in the "skin-core" structure. The composition of the core layer 1 is polyester, the composition of the matrix 21 in the cortex 2 is chit...

Embodiment 3

[0050] The inner channel of the coaxial electrospinning nozzle is filled with hexafluoroisopropanol solution as a solvent, and a 6wt% polyurethane solution is configured, and the outer channel of the coaxial electrospinning nozzle is filled with hexafluoroisopropanol The solution is a solvent, and an 8wt% collagen solution is prepared, wherein 100 μg / mL amoxicillin and 100 μg / mL lidocaine are dissolved in the collagen solution. Coaxial electrospinning is used for spinning, the receiving voltage of the three-dimensional receiver is 22kV, and the receiving distance is 18cm. The receiver is shaped like Figure 2-5 shown. Multi-component nanofiber structures such as figure 1 As shown, the composition of the core layer 1 is polyurethane, the composition of the matrix 21 in the cortex 2 is collagen, and the composition of the drug 22 is amoxicillin and lidocaine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention discloses an anti-infection covering bag and a preparation method of the anti-infection covering bag. The anti-infection covering bag is prepared by multi-component nanoscale cellosilks through a coaxial electrospinning technology, wherein each multi-component nanoscale cellosilk comprises a core layer and a surface layer, the surface layer covers the core layer, the core layer is made of a biodegradable material or a non-biodegradable material, the surface layer is a mixed layer formed by the biodegradable material and a medicine, and the medicine is uniformly distributed in the biodegradable material of the surface layer. According to the anti-infection covering bag provided by the invention, the medicine is uniformly distributed in the biodegradable material of the surface layer, thus the uniform distribution of the medicine is guaranteed, the problem that the nonuniform distribution of the medicine influences the release process of the medicine is solved, and the anti-infection performances are greatly improved; in addition, the anti-infection covering bag is simple in structure, and easy for popularization and application.

Description

technical field [0001] The invention belongs to a medical textile, in particular to an anti-infection coating bag and a preparation method thereof. Background technique [0002] Cardiac implantable device (CID) is used more and more clinically, and the incidence of infection after CID implantation is also increasing. CID infection not only brings suffering to patients, but also brings many social problems due to the increase of treatment costs after infection. By wrapping the drug-loaded anti-infection coating bag on the outside of the heart implant device, the purpose of anti-infection and pain reduction of patients can be achieved through slow release of drugs. [0003] U.S. Patent No. 8,591,531B2 discloses a covering bag for a cardiac implant device, which is made of a commercial polypropylene patch through ultrasonic heat fusion. uniform. The coating bag described in the Chinese patent CN101332311B coats degradable materials and drugs on the surface of the polypropyle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/14A61L31/04A61L31/06D01F1/10D01F9/00D01F6/62D01F6/70D04H1/728D04H1/76D01D5/00
CPCA61L31/042A61L31/044A61L31/046A61L31/06A61L31/148A61L31/16A61L2300/204A61L2300/21A61L2300/216A61L2300/402A61L2300/406A61L2300/41C08L89/00D01D5/0015D01F1/10D01F6/62D01F6/70D01F9/00D04H1/728D04H1/76C08L5/08C08L75/04C08L33/24C08L33/04
Inventor 杨小元杜广武
Owner ACCUPATH MEDICAL JIAXING CO LTD
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