Preparation method of nano vesicles loaded with active substance of purple sweet potato skin
A technology of nanovesicles and active substances, applied in the field of preparation of nanovesicles, can solve the problems of easily ruptured vesicles, low drug loading rate, intermembrane fusion, etc., and achieve good biocompatibility and permeability, high loading The effect of drug rate, water solubility and targeting
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example 1
[0024] First, take 200g of purple potato skin, wash it, dry it, crush it, and sieve it to get 80 mesh purple potato skin powder, add 80% ethanol solution with a mass fraction of 10mL / g according to the liquid-to-material ratio, mix and extract at 350W power for 70s, and extract The solution was centrifuged at 2000r / min for 15min to remove the precipitate to obtain a supernatant, and the supernatant was centrifuged at 5000r / min for 15min to remove the precipitate to obtain a supernatant, and the supernatant was heated at 60°C Distill down for 40 minutes to obtain a concentrated solution; filter the concentrated solution with a 0.1 μm microfiltration membrane, collect the liquid after the microfiltration, filter the liquid after the microfiltration with a 0.05 μm ultrafiltration membrane, and collect the liquid after the filtrate, which is Active liquid of purple potato peel, for use; accurately weigh 8g ε-caprolactone, 8g polyethylene glycol, 50mL toluene and add it into a round...
example 2
[0027] First, take 250g of purple potato skin, wash it, dry it, crush it, and sieve it to obtain 90-mesh purple potato skin powder. Add 80% ethanol solution with a mass fraction of 11mL / g according to the liquid-to-solid ratio, mix and extract at 400W power for 80s, and extract The solution was centrifuged at 2500r / min for 18min to remove the precipitate to obtain a supernatant, and the supernatant was centrifuged at 6000r / min for 17min to remove the precipitate to obtain a supernatant, and the supernatant was heated at 65°C Distill down for 50 min to obtain a concentrated solution; filter the concentrated solution with a 0.2 μm microfiltration membrane, collect the liquid after the microfiltration, filter the liquid after the microfiltration with a 0.06 μm ultrafiltration membrane, and collect the liquid after the filtrate, which is Active liquid of purple potato skin, for use; accurately weigh 9g ε-caprolactone, 9g polyethylene glycol, 65mL toluene and add it into a round bot...
example 3
[0030] First, take 300g of purple potato skin, wash it, dry it, crush it, and sieve it to get 100 mesh purple potato skin powder, add 80% ethanol solution with a mass fraction of 12mL / g at a liquid-to-solid ratio, mix and extract for 90s under 450W power, and extract The solution was centrifuged at 3000r / min for 20min to remove the precipitate to obtain a supernatant, and the supernatant was centrifuged at 7000r / min for 20min to remove the precipitate to obtain a supernatant, and the supernatant was heated at 70°C Distill down for 60 minutes to obtain a concentrated solution; filter the concentrated solution with a 0.3 μm microfiltration membrane, collect the liquid after the microfiltration, filter the liquid after the microfiltration with a 0.08 μm ultrafiltration membrane, and collect the liquid after the filtrate, which is Active liquid of purple potato peel, for use; accurately weigh 10g ε-caprolactone, 10g polyethylene glycol, 80mL toluene and add it into a round bottom f...
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