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Medicine composition for treating diabetes mellitus

A composition and technology for diabetes, applied in the directions of drug combination, metabolic diseases, pharmaceutical formulations, etc., to achieve obvious effect and reduce the effect of glycosylated hemoglobin

Inactive Publication Date: 2016-07-13
天津中津药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although insulin can be used to treat diabetes, it remains a serious disease that causes much death and morbidity worldwide

Method used

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  • Medicine composition for treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A pharmaceutical composition comprising the following components in parts by mass: 160 parts of zinc citrate, 60 parts of porcine prostate extract, 80 parts of adrenal gland extract, 35 parts of Shenjincao extract, 30 parts of pig hair vegetable extract, 60 parts of Eucommia ulmoides extract And excipients arachidonic acid 80 and cyclo(His-Pro)3;

[0040] The preparation method of above-mentioned pharmaceutical composition comprises the steps:

[0041] 1) Preparation of adrenal extract:

[0042] Add an equal volume of ethanol with a mass percentage of 95% to the minced porcine adrenal gland, then add sodium hydroxide to adjust the pH to 10, stir evenly, and reflux with nitrogen for 10 hours to obtain a saponified solution. Cool the saponified solution to 50°C, add hydrochloric acid to adjust the pH to 3, separate layers, extract the emulsified layer with ether, combine the ether extract and oil layer, concentrate the mixture of ether extract and oil layer to 1 / 2 of the...

Embodiment 2

[0049] A pharmaceutical composition comprises the following components in parts by mass: 60 parts of zinc citrate, 80 parts of porcine prostate extract, 60 parts of adrenal gland extract, 40 parts of Shenjincao extract, 30 parts of pig hairy vegetable extract, 60 parts of Eucommia ulmoides extract And excipients arachidonic acid 80 and cyclo(His-Pro) 7;

[0050] The preparation method of above-mentioned pharmaceutical composition comprises the steps:

[0051] 1) Preparation of adrenal extract:

[0052] Add ethanol with a mass percentage of 95% to the pig adrenal homogenate, the amount of ethanol added is 3 times the mass of the adrenal homogenate, stir and extract at 55°C for 2 hours, extract twice, filter and combine the filtrate, concentrate to remove ethanol , add diethyl ether, stir at 24 DEG C for 3 hours and extract twice, combine the diethyl ether extracts, concentrate and remove the diethyl ether to obtain a lipid, add 1.5 times its mass of ethanol of 95% by mass to t...

Embodiment 3

[0059] A pharmaceutical composition comprises the following material components in parts by mass: 220 parts of zinc citrate, 100 parts of pig prostate extract, 80 parts of adrenal gland extract, 60 parts of Herba chinensis extract, 40 parts of pig hair vegetable extract, and Eucommia ulmoides extract 80 and excipients arachidonic acid 150 and cyclo(His-Pro)6;

[0060] The preparation method of the above-mentioned pharmaceutical composition is as described in Example 2.

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Abstract

The invention discloses a medicine composition for treating diabetes mellitus. The medicine composition is prepared from the following components in parts by mass: 10-300 parts of zinc salt, 10-200 parts of extract of prostate glands of mammal except human, 10-200 parts of extract of adrenal glands, 1-100 parts of lycopodium clavatum extract, 1-100 parts of salsola collina extract, 10-150 parts of eucommia ulmoides extract and pharmaceutically acceptable auxiliaries. The medicine composition can be used for treating diabetes and mellitus, can be used for reducing the concentration of glycosylated hemoglobin and blood glucose, and is an effective medicine composition for treating diabetes mellitus.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating diabetes. Background technique [0002] Diabetes is the most common metabolic disorder in humans. Most treat insulin-dependent, or type 1 diabetes, as well as insulin-independent diabetes, both of which impair the body's ability to use glucose for energy. Chronic high blood sugar can slowly damage many tissues and organs in the body. Although insulin can be used to treat diabetes, diabetes remains a serious disease that causes much death and morbidity worldwide. The consequences of long-term diabetes can include eye damage, often leading to blindness, circulatory problems, wound healing problems, and other serious consequences. [0003] Studies in recent years have shown that the appearance of diabetes may be related to zinc ions in cells. Animals and humans with diabetes have low levels of zinc in plasma. At the same time, zinc is an in...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61P3/10A61K31/194A61K35/52A61K35/22
CPCA61K31/194A61K35/22A61K35/52A61K36/11A61K36/185A61K36/46A61K2236/33A61K2236/39A61K2236/55A61K2300/00
Inventor 宋富智梁世昌王培松
Owner 天津中津药业股份有限公司
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