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Drug preparation for reversing gastric cancer drug resistance and application thereof

A drug preparation and drug resistance technology, applied in the field of medicine, can solve the problems of no reversal agent, etc., and achieve the effects of prolonging survival, shrinking tumor lesions, drug efficacy and functions

Inactive Publication Date: 2016-08-10
QINGDAO CHENDA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been three generations of ABCB1 inhibitors, and the third-generation reversal agent has entered the clinical research stage, but so far no reversal agent has passed the approval of the US Food and Drug Administration (FDA)

Method used

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  • Drug preparation for reversing gastric cancer drug resistance and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A pharmaceutical preparation for reversing drug resistance of gastric cancer, the ingredients include: 10 parts of rhubarb, 8 parts of ginger, 20 parts of Radix radix radix, 10 parts of Peucedanum, 20 parts of astragalus, 10 parts of licorice, 15 parts of kudzu root, 20 parts of angelica, 25 parts of psoralen, 20 parts of madder, 15 parts of Panax notoginseng, 15 parts of earthworm, 15 parts of Shanzi mushroom, 15 parts of poria cocos, 20 parts of saponins, 12 parts of Hedyotis diffusa 15 parts, 15 parts of saffron.

[0047] The above Chinese medicine composition is prepared into a decoction, and its specific preparation method:

[0048] Raw materials of traditional Chinese medicine: Rhubarb, Ginger, Cordyceps japonicus, Peucedanum, Astragalus, Licorice, Pueraria, Angelica, Psoraleae, Rubia, Panax notoginseng, Earthworm, Arrowhead mushroom, Poria cocos, Saponaria thorn, Angelica, Hedyotis diffusa Grass, saffron, soak in pure water, the water surface is 3-5cm higher tha...

Embodiment 2

[0050] A pharmaceutical preparation for reversing drug resistance of gastric cancer, the components of which include:

[0051] 15 parts of Rhubarb, 18 parts of Ginger, 20 parts of Dong Lingcao, 5 parts of Peucedanum, 6 parts of Astragalus, 15 parts of Licorice, 10 parts of Pueraria Root, 12 parts of Angelica, 22 parts of Psoralen, 18 parts of Rubia, 12 parts of Panax notoginseng, 20 parts of Earthworm, 15 parts of Shanzigu, 20 parts of Poria cocos, 20 parts of saponins, 12 parts of Hedyotis diffusa, 10 parts of saffron.

[0052] The above Chinese medicine composition is prepared into granules, and its specific preparation method:

[0053] (1) Raw materials of traditional Chinese medicines, rhubarb, ginger, winter lingon, peucedanum, astragalus, licorice, kudzu root, angelica, psoralen, madder, panax notoginseng, earthworm, mountain arrow mushroom, poria cocos, saponin thorn, angelica, Hedyotis diffusa and saffron are soaked in pure water, the water surface is 3-5cm higher tha...

Embodiment 3

[0058] A pharmaceutical preparation for reversing drug resistance of gastric cancer, the components of which include:

[0059] 20 parts of rhubarb, 17 parts of ginger, 12 parts of winter grass, 12 parts of peucedanum, 9 parts of astragalus, 6-15 parts of licorice, 18 parts of kudzu root, 18 parts of angelica, 22 parts of psoralen, 19 parts of madder, 20 parts of Panax notoginseng , 22 parts of Earthworm, 18 parts of Shanzigu, 12 parts of Poria cocos, 22 parts of saponins, 18 parts of Hedyotis diffusa, 12 parts of saffron.

[0060] The above Chinese medicine composition is prepared into a tablet, and its specific preparation method:

[0061] Raw materials of traditional Chinese medicine: Rhubarb, Ginger, Cordyceps japonicus, Peucedanum, Astragalus, Licorice, Pueraria, Angelica, Psoraleae, Rubia, Panax notoginseng, Earthworm, Arrowhead mushroom, Poria cocos, Saponaria thorn, Angelica, Hedyotis diffusa Grass and saffron, after soaking with ethanol for 8-12 hours, reflux twice wi...

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Abstract

The invention belongs to the field of medicine, and particularly relates to a drug preparation for reversing gastric cancer drug resistance and application thereof. The drug preparation is prepared from rheum officinale, ginger, herba rabdosiae, radix peucedani, radix astragali, liquorice root, radix puerariae, radix angelica sinensis, fructus psoraleae, radix rubiae, pseudo-ginseng, earthworms, edible tulip, poria cocos, spina gleditsiae, semen hyoscyami, spreading hedyotis herbs and saffron crocus. The formula is economical, affordable and suitable for gastric cancer patients in various age groups, and the composition formed through the traditional Chinese medicine formula is low in treatment side effect and can be used in cooperation with multiple chemotherapy drugs to reduce tumor focus and prolong life time of tumor patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical preparation for reversing drug resistance of gastric cancer and its application. Background technique [0002] Tumor is the "No. 1 killer" that threatens human health. Currently, there are three methods of tumor treatment: surgical treatment, radiotherapy and chemotherapy. In 1943, humans used nitrogen mustard for the first time to treat lymphoma, which opened a new era of modern cancer chemotherapy. With the deepening of research and the research and development of anticancer drugs, chemotherapy has become the main means of malignant tumor treatment. However, long-term use of chemotherapy drugs often leads to a new problem—tumor multidrug resistance (MDR), which leads to the failure of tumor chemotherapy. Multidrug resistance of tumor cells to chemotherapeutic drugs is the main obstacle to cancer treatment and the main reason for the poor prognosis of most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P35/00A61K35/62
CPCA61K36/9068A61K35/62A61K36/076A61K36/23A61K36/232A61K36/258A61K36/481A61K36/483A61K36/484A61K36/487A61K36/488A61K36/53A61K36/708A61K36/74A61K36/748A61K36/81A61K36/88A61K36/898A61K2300/00
Inventor 陈令浩
Owner QINGDAO CHENDA BIOLOGICAL SCI & TECH
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