44results about How to "Less side effects of treatment" patented technology

The invention discloses a minimally invasive collective integral acupotomy scope, which comprises a light microscope assembly of a scope-acupotomy integral body, a tube core assembly of the scope-acupotomy integral body and a hard sleeve assembly of the scope-acupotomy integral body. The light microscope assembly of the scope-acupotomy integral body comprises a lens, a lens base and a light guide tube. The tube core assembly of the scope-acupotomy integral body comprises a knife tube core. The hard sleeve assembly of the scope-acupotomy integral body comprises a knife tube. The light guide tube is inserted in the knife tube core. The knife tube core is inserted in the knife tube. An operation method of the minimally invasive collective integral acupotomy scope disclosed by the invention comprises the following steps of: (1) holding the acupotomy scope, and inserting the acupotomy scope into a knee joint through front external approach; (2) opening a water inlet channel to full a joint cavity; and (3) sequentially searching suprapatellar bursa, patellofemoral joint, internal tibia clearance, fossa intercondyloidea, external tibia clearance, knee lateralis sulci, rear internal clearance and rear external clearance, wherein the scope surface angle of the whole acupotomy scope is correspondingly adjusted according to searched specific parts in the searching process.

The invention relates to a chimeric antigen receptor and an expression gene thereof, a double-antigen regulated type T cell modified by the chimeric antigen receptor, and application thereof. The expression gene of the chimeric antigen receptor comprises a first fusion protein expression gene and a second fusion protein expression gene, wherein the first fusion protein expression gene comprises a mucoprotein-1 antibody expression gene, a notch receptor expression gene and a Gal4-VP64 transcription activating protein expression gene which are sequentially connected; the second fusion protein expression gene comprises a Gal4-UAS promoter expression gene and an anti-mesothelin expression gene which are sequentially connected. By adopting the innovative design, the chimeric antigen receptor has the advantages that the chimeric antigen receptor can be successfully imported into the T cell to form the T cell modified by the chimeric antigen receptor; the immune reaction cannot be produced until the mucoprotein-1 and the anti-mesothelin signals simultaneously exist, so as to reach the controllable immune reaction of the chimeric antigen receptor, fewer side effects in treatment, and high specificity.

The invention discloses a breast cancer metastasis therapeutic device which can integrate pointed restoration function treatment and surgery chemoradiotherapy and prevent and treat breast cancer metastasis. The breast cancer metastasis therapeutic device is composed of vibration squeezing friction heads, an adjustable switch, a semi-circular fixer and a square fixer, belongs to the advanced therapeutic technology integrally combining laser, ultrasonic waves, microwaves, therapeutic massage and anti-cancer drug injection and performs treatment for diseased region function restoration and cancer cell spreading prevention. According to a breast cancer metastasis emergence and development principle schematic diagram and a breast cancer metastasis therapeutic principle and technique schematic diagram in a manual, human body system level function decreasing and system level structural damage symmetric mutual restriction causes breast cancer metastasis. By adopting the breast cancer metastasis therapeutic device, system level function decreasing part treatment and surgery chemoradiotherapy cancer cell killing system level structural damage resistant treatment are mutually symmetrically and equivalently promoted and are integrally combined to form an etiological treatment mode, and therefore the treatment purpose of controlling and eliminating breast cancer metastasis is achieved.

The invention provides a biocompatible boric acid nano-drug compound and preparation method thereof, wherein the composition comprises natural polyphenols, boric acid drugs and high molecular compounds. In an organic solvent, boric acid drugs are firstly mixed with natural polyphenols to obtain a compound containing boric acid drugs and natural polyphenols, and then the previously obtained compound is mixed with the high-molecular compound to obtain a boric acid anticancer nano-drug compound containing boric acid drugs, natural polyphenols and high-molecular compounds, the nano-drug compound has excellent tumor cell inhibition potency and biocompatibility, the preparation method provided by the invention is simple and safe, the prepared boric acid nano-drug compound can efficiently and safely carry out boric acid drug delivery, and has excellent medical value.

The invention belongs to the field of biomedicine, and specifically relates to a combined medicine containing berberine hydrochloride and PD1-antibody for preventing and/or treating tumor. The medicine comprises preparations of different specifications of units of berberine hydrochloride and PD1- Antibody, said PD- 1 antibody is preferably Nivolumab. The invention accidentally finds that the combination of berberine hydrochloride and Nivolumab improves the sensitivity of the experimental tumor-bearing mice to Nivolumab drugs, and the weight of the experimental tumor-bearing mice is kept stableafter the treatment course is finished; At the same time, the combination of the two has a synergistic effect, and the inhibiting ability of the combination is significantly superior to that of usingNivolumab alone, and the combination has made remarkable progress compared with the prior art.

The invention provides a pharmaceutical preparation for treating pancreatic cancer and application thereof. The pharmaceutical preparation comprises the following ingredients in parts by weight: 8-15 parts of dangshen, 10-20 parts of self-heal, 5-15 parts of fried bighead atractylodes rhizome, 10-20 parts of oldenlandia, 20-30 parts of fiveleaf akebia fruit, 10-20 parts of tuckahoe, 10-20 parts of poria cocos, 10-20 parts of rhizoma pleionis, 15-30 parts of roasted malt, 10-15 parts of herba scutellariae barbatae, 10-20 parts of Chinese yam, 5-15 parts of fructus trichosanthis, 10-20 parts of pericarpium arecae, 20-30 parts of grifola umbellata, 10-20 parts of ginger processed pinellia, 10-20 parts of coix seeds, 20-30 parts of panicled swallowwort roots, 20-30 parts of spatholobus stem and 3-5 parts of ardisia crenata. The traditional Chinese medicine prescription is economical and applicable, is used for treating pancreatic cancer by strengthening the spleen and stomach, removing dampness, regulating the flow of qi, promoting blood circulation and relieving toxicity, and is suitable for patients suffering pancreatic cancer in various ages. The pharmaceutical preparation can be combined with multiple chemotherapy drugs for use, so that the tumor focus is reduced, the lifetime of tumor patients is prolonged, the harm and side effects on the body caused by radiotherapy and chemotherapy can be reduced, and the immunity and anti-tumor capability of the body are increased.

The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer, as well as other types of malignancy, including brain metastases of NSCLC. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is activeagainst tumors that are refractory to temozolomide, cisplatin, and tyrosine kinase inhibitors; the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together withother anti-neoplastic agents and can possess additive or super-additive effects.

The invention relates to a medicinal composition for treating cholelithiasis. The composition is prepared from water extracts of clematis root, clerodendranthus spicatus, hiraute shiny bugleweed herb, Chinese thorowax root, turmeric root-tuber and crude rhubarb, and is prepared into an oral preparation prepared from a pharmaceutically-acceptable excipient. A medicament has the effects of soothing liver-gallbladder, promoting catharsis and removing urinary calculus on cholelithiasis, can be used for effectively treating gallstone and preventing relapse of gallstone after surgery, and can be widely applied to clinical treatment.

The invention discloses a tumor ECM degrading and/or inhibiting agent and a complete set kit and application thereof. The tumor ECM degrading and/or inhibiting agent comprises at least two kinds of ananti-hyaluronidase agent, an anti-collagen agent, and an anti-tissue agent. The tumor ECM degrading and/or inhibiting agent can effectively degrade or restrain generation of a tumor extracellular matrix in a broadspectrum manner, and the tumor penetrability is improved, so that drugs can effectively enter tumors to be in contact with and kill tumor cells, and improve the medication effect. The combination manner can be applied in an intratumoral injection manner, so that the applying concentration of single components can be reduced, and the side effect is low. The complete set kit can increase the medication effect, the medicament dose can be reduced, and dosage required for achieving the same effect by an antitumor intratumoral injection manner is lower than that used for venous or other nonintratumoral injection, the antitumor dosage is reduced, and besides, the antitumous effects are increased.

The invention provides a traceable boric acid nano-drug compound and a preparation method thereof. The traceable boric acid nano-drug compound comprises natural polyphenol, a boric acid drug and ironions. The preparation method includes: in an organic solution, firstly mixing the boric acid drug with natural polyphenol, and then mixing the obtained product with iron ions to obtain the boric acidanticancer nano-drug compound containing the boric acid drug, natural polyphenol and iron ions. The traceable boric acid nano-drug compound can be used for tumor tracing and the like. The invention also puts forward application of the nano-drug compound in preparation of drugs for prevention and/or treatment of tumors and inflammatory diseases. The nano-drug compound also has tracing ability, canensure that anti-cancer drugs only take effect at tumor sites so as to reduce side effects, and has better biocompatibility and better therapeutic efficiency. The traceable boric acid nano-drug compound provided by the invention has the characteristics of simple and safe synthesis, efficient and safe delivery of boric acid drugs, and has excellent medical value.

The invention discloses a robot radiotherapy system, which includes a C-arm imaging device, a treatment couch, a treatment robot and a mobile device. The treatment robot, the C-arm imaging device and/or the bottom of the treatment couch are equipped with the a moving device for changing the position of the treatment robot, the C-arm imaging device or the treatment couch. The robot radiation therapy system expands the treatment space by installing a mobile device on the bottom of the treatment robot, the C-arm imaging device or the treatment couch, provides more treatment beam incident points, and effectively avoids Normal tissues and organs are opened, which improves the quality of treatment and reduces the side effects of treatment.

The invention relates to a medicinal preparation for treating an Alzheimer disease and an application of the medicinal preparation. The medicinal preparation comprises coptis, perilla stems, epimedium, semen cuscutae, black soya beans, holly leaves, obcordateleaf raspberry fruits, burdock, wild rice shoots, orchis, liquorice, rhizoma acori graminei, polygala tenuifolia, rhodiola rosea, root of kudzu vine, eupatorium, piper cubeba, sophora flowers, Chuanxiong rhizome and borneol. The traditional Chinese medicine formula treats the Alzheimer disease by a qi regulating and blood circulation activating method. The medicinal preparation in the traditional Chinese medicine formula is low in therapeutic side effect and prepared from traditional Chinese medicines serving as raw materials through the scientific formula and repeated verification and preparation of clinical tests, conforms to the theory of traditional Chinese medicine, improves body immunity, has multiple action targets, is high in effective rate and suitable for clinical popularization and application, and has high development values.

The invention provides a pharmaceutical composition for treating the renal clear cell carcinoma and an application thereof. The pharmaceutical composition comprises a fat browning inhibitor and a first-line renal cancer treatment drug, wherein the first-line renal cancer treatment drug is selected from sunitinib, sorafenib, axitinib and pazopanib to form four combinations. The fat browning inhibitor in the pharmaceutical composition can improve the anti-cancer effects of the four kinds of first-line renal cancer treatment drugs, solve the problem that the four kinds of first-line renal cancertreatment drugs can cause white fat cell browning, further possibly damage the anti-cancer curative effect and cause drug resistance, reduce the treatment side effects of the drugs, and provide a newstrategy for treatment of the renal clear cell carcinoma.

The invention discloses a preparation method of a second near-infrared window nano photosensitizer based on NDI molecules. The method comprises the following steps: A, reacting 1,4,5,8-naphthalene tetracarboxylic anhydride with dibromoisocyanuric acid under the catalysis of fuming sulfuric acid to generate tetrabromo-substituted naphthalene tetracarboxylic anhydride; B, performing an alkylation reaction on the tetrabromo-substituted naphthalene tetracarboxylic anhydride and dodecylamine, and performing cyclization with 1,5-diaminonaphthalene to obtain an NDI photosensitizer; and C, dissolvingthe NDI photosensitizer prepared in the step A into tetrahydrofuran, then slowly dropwise adding into rapidly stirred pure water, carrying out rotary evaporation on tetrahydrofuran, and then centrifuging to obtain the multifunctional NDI nano photosensitizer. According to the invention, the defects in the prior art can be overcome, the biological tissue penetrating power can be effectively enhanced, the fluorescence imaging signal-to-noise ratio is reduced, and high-resolution and high-contrast oral squamous cell carcinoma tissue optical imaging real-time monitoring is achieved.

The invention belongs to the field of medicine, and particularly relates to a drug preparation for reversing gastric cancer drug resistance and application thereof. The drug preparation is prepared from rheum officinale, ginger, herba rabdosiae, radix peucedani, radix astragali, liquorice root, radix puerariae, radix angelica sinensis, fructus psoraleae, radix rubiae, pseudo-ginseng, earthworms, edible tulip, poria cocos, spina gleditsiae, semen hyoscyami, spreading hedyotis herbs and saffron crocus. The formula is economical, affordable and suitable for gastric cancer patients in various age groups, and the composition formed through the traditional Chinese medicine formula is low in treatment side effect and can be used in cooperation with multiple chemotherapy drugs to reduce tumor focus and prolong life time of tumor patients.

The invention relates to a medicinal preparation for treating lung cancer and a preparation method thereof. The medicinal preparation comprises codonopsis radix, corn stigma, snakegourd fruit, licorice root, dysosma versipelis, selfheal spike, hedyotis diffusa, Akebia trifoliata Koidz, poria cocos, rhizoma pleionis, scutellariae barbatae, ginger processed pinellia, coix seed, radix cynanchi panicullati, spatholobus suberctu, periostracum cicadae and radix sophorae tonkinensis. The traditional Chinese medicine formula treats the lung cancer by utilizing qi regulating, blood circulation activating, and detoxifying methods, can effectively shrink tumor lesion, reduces damage and side effects of chemoradiotherapy to the bodies of patients, and meanwhile, improves the immunity and the anti-tumor ability of the bodies, thereby having a higher development value.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical preparation for treating an esophagus cancer and an application of the pharmaceutical preparation. The pharmaceutical preparation is prepared from snakegourd fruits, rabdosia rubescens, tamarix chinensis, cimicifugae foetidae, burdock, red peony roots, radix peucedani, platycodon grandiflorum, earthworm, cockscomb, pericarpium citri reticulatae viride, fructus forsythia, raw oyster shell, kelp, indigo naturalis, codonopsis pilosula, oldenlandia diffusa, fiveleaf akebia fruits, semen coicis, radix cynanchi panicullati, caulis kadsurae, berchemia lineate and radix clematidis. The composition is economical and applicable; the esophagus cancer is treated by the methods of regulating qi circulation, activating blood circulation and removing toxin. The pharmaceutical preparation of the traditional Chinese medicine composition is low in side effect in treatment; the tumor focus is reduced; the lifetime of a tumor patient is prolonged; the harm and the side effect of chemoradiotherapy to a body are reduced; meanwhile, the immunity and the anti-tumor ability of the body are improved; and the pharmaceutical preparation has relatively high development value.

The invention relates to lipid-coated albumin-bound chemotherapeutic drug nanoparticles as well as a preparation method and application thereof. According to the invention, lipid molecules are wrapped on the surfaces of albumin-bound chemotherapeutic drug nanoparticles, and are further mixed with genes to prepare lipid albumin nanoparticles carrying genes and chemotherapeutic drugs; or albumin is prepared into nanoparticles, and lipid molecules are wrapped on the surfaces of the nanoparticles, and are further mixed with the genes to obtain the lipid albumin nanoparticles for cell transfection or gene therapy. The preparation method has the advantages of green and environment-friendly effects, good repeatability, simple and convenient preparation method and high yield, the prepared nanoparticles are regular in morphology and uniform in particle size, the loaded genes have very good transfection efficiency, and the nanoparticles have wide application prospects in the field of tumor treatment, especially the field of drug-resistant tumor treatment.

The invention provides an application of cuprous oxide nanoparticles for preparing a drug for treating and/or preventing bladder cancer. A nano-drug of the cuprous oxide nanoparticles has the good features of a nano material, and shows the remarkable selective anti-tumor effect in an in-vitro experiment. At the same time, the cuprous oxide nanoparticles can be rapidly metabolized in an animal body, and apparent liver and kidney toxicity and other important organ injuries are not discovered, the safety is higher. The application provides new application for a cuprous oxide nanoparticle preparation, and provides a new pharmacy selection for chemotherapy of the bladder cancer. A relapse rate of the bladder tumor is reduced, the side effect of the drug therapy is reduced, and the quality of life of a patient is improved, so the cuprous oxide nanoparticle preparation has a good clinical application prospect.

The invention discloses a composition containing arsenic trioxide for curing a lung cancer and an application therefore that belongs to the technical field of cancer treatment. The composition containing arsenic trioxide for curing the lung cancer consists of ingredients by weight percentages as follows: an ingredient A, including 1-50 portions of arsenic trioxide, 5-125 portions of croton, 2-20 portions of black pepper, and 10-40 portions of jujube; an ingredient B, including 1-25 portions of arsenic trioxide, and 2-60 portions of croton. The composition containing arsenic trioxide for curing the lung cancer is low in preparation cost, easy in popularization, easy in operation, less in side effect of drug use for treatment, free of expensive hospitalization costs and complex facilities as well as devices. More importantly, the composition containing arsenic trioxide for curing the lung cancer is free of the chemotherapy and the drug resistance problems in Western medicine; and the composition containing arsenic trioxide for curing the lung cancer can be used year-round. The composition containing arsenic trioxide for curing the lung cancer takes effect instantly; the symptoms, such as cough, chest distress, and suffocated feeling, that trouble the lung cancer patients, can be relieved effectively; the composition containing arsenic trioxide for curing the lung cancer has an obvious effect for inhibiting lung tumors. The life quality can be improved and the time to live can be extended effectively by keeping using this therapy for a long time.