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3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid and extraction method thereof

A technique for extracting Asparagus folic acid and its extraction method, which is applied in the fields of steroids, organic chemistry, non-central analgesics, etc., and can solve the problems of unclear mechanism of action and effective material basis, and restrictions on the development of Asparagus leaf application products, etc. Achieve the effect of simple and easy extraction method, good effect and high extraction rate

Active Publication Date: 2016-08-10
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are few researches on the material basis of the active ingredients and anti-inflammatory effects of Asparagus leaves at home and abroad, and its mechanism of action and material basis of pharmacodynamics are still unclear, which greatly limits the application of Asparagus leaves and the development of related products

Method used

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  • 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid and extraction method thereof
  • 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid and extraction method thereof
  • 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid and extraction method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] The extraction method of asparagus folic acid comprises the following steps:

[0033] 1) using asparagus leaf coarse powder as raw material, ethanol as solvent, adopting the percolation method to extract, and obtaining the first extract after evaporating the ethanol solvent;

[0034] 2) adding water to the first extract to form a suspension, then adding petroleum ether and ethyl acetate to the suspension for extraction to obtain an extract, and evaporating to remove the ethanol solvent in the extract to obtain a second extract;

[0035] 3) Take the second extract, use chloroform and methanol as the eluent, carry out gradient elution, and then use the chloroform-methanol fraction with a volume ratio of 60:1 to obtain a white powder, which is the target product 3β-hydroxyl -23, 25β, 26α, 27β, 28β-tetramethyl-21-isopropyl-13(18)-sterene-24-oic acid.

Embodiment 2

[0037] The extraction method of asparagus folic acid comprises the following steps:

[0038] 1) using asparagus leaf coarse powder as raw material, ethanol as solvent, adopting the percolation method to extract, and obtaining the first extract after evaporating the ethanol solvent;

[0039] 2) adding water to the first extract to form a suspension, then adding petroleum ether and ethyl acetate to the suspension for extraction to obtain an extract, and evaporating to remove the ethanol solvent in the extract to obtain a second extract;

[0040] 3) Take the second extract, use chloroform and methanol as the eluent, carry out gradient elution, and then use the chloroform-methanol fraction with a volume ratio of 80:1 to obtain a white powder, which is the target product 3β-hydroxyl -23, 25β, 26α, 27β, 28β-tetramethyl-21-isopropyl-13(18)-sterene-24-oic acid.

Embodiment 3

[0042] The extraction method of asparagus folic acid comprises the following steps:

[0043] 1) using asparagus leaf coarse powder as raw material, ethanol as solvent, adopting the percolation method to extract, and obtaining the first extract after evaporating the ethanol solvent;

[0044] 2) adding water to the first extract to form a suspension, then adding petroleum ether and ethyl acetate to the suspension for extraction to obtain an extract, and evaporating to remove the ethanol solvent in the extract to obtain a second extract;

[0045] 3) Take the second extract, use chloroform and methanol as the eluent, carry out gradient elution, and then use the chloroform-methanol fraction with a volume ratio of 90:1 to obtain a white powder, which is the target product 3β-hydroxyl -23, 25β, 26α, 27β, 28β-tetramethyl-21-isopropyl-13(18)-sterene-24-oic acid.

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Abstract

The invention discloses 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid. The 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid has a structural formula shown in the description. An extraction method of the 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid comprises 1, carrying out percolation extraction on Sauropus rostratus Miq. crude powder as a raw material in an ethanol solvent and evaporating the ethanol solvent so that first extract is obtained, 2, adding water into the first extract to obtain a fluid suspension, adding petroleum ether and ethyl acetate into the fluid suspension, carrying out extraction to obtain extract and evaporating to remove the ethanol solvent in the extract so that second extract is obtained, and 3, taking the second extract, carrying out gradient elution through chloroform and methanol as eluants and carrying out chloroform-methanol flow separation to obtain white powder which is 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid. The method realizes extraction of 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid in Sauropus rostratus Miq., is simple and easy and has a high extraction rate. The 3 beta-hydroxy-26 alpha, 27 beta-arbor-13(18)-ene-24-carboxylic acid has good anti-inflammatory effects.

Description

technical field [0001] The present invention relates to a compound and its extraction method. More specifically, the present invention relates to asparagus folic acid and its extraction method. Background technique [0002] Sauropus rostratus Miq. is a plant of the genus Gecko in the Euphorbiaceae family. It is abundant in Indonesia, Vietnam, and my country's Yunnan, Guangxi, Fujian and other places. Among them, folks in Guangdong and Guangxi are used as therapeutic medicinal materials. It is more common in herbal teas. It has the effects of clearing away heat and moistening lungs, reducing phlegm and relieving cough. Asparagus leaves have various pharmacological activities such as anti-allergic, antibacterial, anti-inflammatory and analgesic; in clinical practice, many prescriptions based on asparagus leaves are often used to treat respiratory diseases such as pneumonia and bronchitis, such as Qianlong mixture (wood butterfly, asparagus leaf, heterophylla, Ophiopogon japo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61P29/00
CPCC07J63/008
Inventor 卢汝梅莫惠雯韦建华李兵霍丽妮
Owner GUANGXI UNIV OF CHINESE MEDICINE
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