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Meniscus support and production method thereof

A meniscus and annular stent technology, applied in medical science, prosthesis, elbow joint, etc., can solve the problem of poor meniscus effect, and achieve the effect of promoting adhesion and proliferation, increasing surface area, and increasing the number of cells

Active Publication Date: 2016-08-17
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a meniscus bracket made of homogeneous or heterogeneous cancellous bone and a preparation method thereof for the defect that the meniscus repair effect is not good at present

Method used

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  • Meniscus support and production method thereof
  • Meniscus support and production method thereof
  • Meniscus support and production method thereof

Examples

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preparation example Construction

[0037] see figure 1 , is a flowchart of a method for preparing a meniscus bracket according to a preferred embodiment of the present invention. Such as figure 1Shown, the preparation method of meniscus support of the present invention, comprises the following steps:

[0038] (1) In step S1, take heterogeneous or allogeneic cancellous bone from the femoral or tibial metaphysis, remove the surrounding attached tissues, including surrounding muscles, ligaments, tendons and epiphyseal tissues, and use an electric pendulum saw to cut out the planned Thick cancellous bone slices were washed with tap water and soaked in distilled water. When used to prepare the meniscus bracket of the human body, its thickness is 6-8mm. Preferably, the thickness of the cancellous bone piece cut out in this step is 7mm. In order to prepare a meniscal support suitable for human use, the femur or tibia of the heterogeneous bone used in the present invention includes but not limited to the femur or t...

Embodiment 1

[0050] 1. Take the cancellous bone from the femoral metaphysis of adult pigs, remove the surrounding attached tissues, including surrounding muscles, ligaments, tendons and epiphyseal tissues, use an electric pendulum saw to cut cancellous bone slices with a thickness of 6mm, clean them with tap water, and use them Soak in distilled water.

[0051] 2. Soak the cancellous bone slices in a hydrochloric acid solution with a mass concentration of 4.5% for 2 days for decalcification, and wash them with distilled water after taking them out.

[0052] 3. Soak the decalcified cancellous bone slices in a methanol / chloroform solution with a volume concentration of 1:0.9 for 20 hours to degrease them, take them out and wash them with distilled water.

[0053] 4. Soak the degreased cancellous bone slices in a hydrogen peroxide solution with a mass concentration of 2.5% for 3-5 hours to deproteinize them, take them out and wash them with distilled water.

[0054] 5. Use a trephine to pres...

Embodiment 2

[0057] 1. Take the cancellous bone from the femoral metaphysis of an adult pig, remove the surrounding attached tissues, including surrounding muscles, ligaments, tendons and epiphyseal tissue, use an electric pendulum saw to cut cancellous bone slices with a thickness of 8mm, clean them with tap water, and use them Soak in distilled water.

[0058] 2. Soak the cancellous bone slices in a hydrochloric acid solution with a mass concentration of 5.5% for 3 days for decalcification, and wash them with distilled water after taking them out.

[0059] 3. Soak the decalcified cancellous bone slices in a methanol / chloroform solution with a volume concentration of 1:1.1 for 28 hours to degrease, take them out and wash them with distilled water.

[0060] 4. Soak the degreased cancellous bone slices in 3.5% hydrogen peroxide solution for 5 hours to deproteinize them, take them out and wash them with distilled water.

[0061] 5. Use a trephine to press on the processed cancellous bone sl...

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Abstract

The invention relates to a meniscus bracket and a preparation method thereof. The preparation method comprises the following steps: taking heterogeneous or allogeneic cancellous bone of femur or tibial metaphysis, removing surrounding attached tissues, and using an electric pendulum saw to cut out Cancellous bone slices with a predetermined thickness are soaked in distilled water after cleaning; the cancellous bone slices are processed into ring-shaped scaffolds after decalcification, fat-removing and protein removal; finally, the ring-shaped scaffolds are freeze-dried at -20°C and irradiated with cobalt 60 Sterilize and store at -80°C for more than 2 weeks to obtain a meniscus scaffold. The meniscal scaffold made of demineralized cancellous bone in the present invention has biological activity and can promote the adhesion and proliferation of cells; and the annular shape also increases the surface area, which is conducive to the full exchange of substances between cells and culture medium, and reduces Apoptosis, thereby increasing the number of cells.

Description

technical field [0001] The invention relates to the technical field of biomaterials and tissue engineering, and more specifically relates to a meniscus bracket and a preparation method thereof. Background technique [0002] The meniscus is composed of fibrocartilage, one on the inside and one on the outside. It is located in the joint space of the knee joint and is an important part of the knee joint. The meniscus has important functions such as absorbing shock, transmitting load, nourishing articular cartilage and lubricating, increasing joint contact area and maintaining joint stability. Severe damage or removal of the meniscus will accelerate the progression of the knee joint to osteoarthritis. Although meniscectomy has the advantages of good short-term curative effect and rapid functional recovery, the quality of the regenerated meniscus after meniscectomy cannot perform the biomechanical function of the normal meniscus, which will inevitably aggravate articular cartila...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61F2/38
Inventor 江东余家阔张正政
Owner PEKING UNIV THIRD HOSPITAL
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