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Pharmaceutical composition for treating ulcerative colitis as well as preparation method and application of pharmaceutical composition

A technology of ulcerative colitis and composition, applied in the field of medicine, can solve the problems of many surgical complications, rebound, unstable curative effect, etc., and achieve significant curative effect and low recurrence rate

Inactive Publication Date: 2016-08-24
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, aminosalicylates and corticosteroids are mostly used in clinical treatment of ulcerative colitis, but there are shortcomings such as rebound after drug withdrawal, unstable curative effect, and large side effects of long-term medication; surgical treatment is to remove the entire colon, but Due to the many complications of surgery, it seriously affects the quality of life of patients after surgery

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Cyclic Glycine-Prodipeptide of the present invention

[0029] The preparation method of cycloglycoside-prodipeptide of the present invention refers to the literature "Qin Xiancan, Yu Zhengpeng, etc., synthesis of cyclo(L-group-L-proline) dipeptide [J], Journal of Hainan Normal University: Natural Science Edition, 2008, 21 (2): 173-175" in the ring (L-group-L-pro) dipeptide synthesis method to prepare the cycloglycoside-pro dipeptide of the present invention, the specific method is: L-proline methyl ester and N -tert-butoxycarbonyl-L-glycine as raw material, condensed by DCC to obtain a straight-chain dipeptide, and then de-Boc-protected by HCl / Et2O, and formed into a ring under weakly alkaline conditions to obtain a cyclic (glycine-proline) dipeptide.

Embodiment 2

[0031] Weigh 20g of glutamic acid, 5g of adenosine, 5g of dopamine, 20g of arginine, 10g of glutamine, 10g of threonine, 5g of methionine, 5g of serine, 10g of proline, Peptide 10g (prepared by the method in Example 1), mix well, add purified water to dissolve to 1000ml, stir and mix, add 50ml glycerin and 1g potassium sorbate, adjust the pH value to 6.5-7.5, filter, potting, Sterilize at 115°C for 30 minutes, pack, and get ready.

Embodiment 3

[0033] Weigh 20g of glutamic acid, 5g of adenosine, 5g of dopamine, 20g of arginine, 10g of glutamine, 10g of threonine, 5g of methionine, 5g of serine, 10g of proline, 10g of peptide (prepared by the method of Example 1), after mixing, add 79g of starch and 8g of sodium carboxymethyl starch, mix evenly, granulate, then add 2g of micropowder silica gel, fill it into enteric-coated capsules, and obtain.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating ulcerative colitis as well as a preparation method and an application of the pharmaceutical composition. The pharmaceutical composition consists of the following components in parts by weight: 5-35 parts of glutamic acid, 1-10 parts of adenosine, 1-10 parts of dopamine, 5-35 parts of arginine, 5-25 parts of glutamine, 5-25 parts of threonine, 1-10 parts of methionine, 1-10 parts of serine, 5-25 parts of proline and 5-25 parts of cyclo-(gly-pro) dipeptide. The pharmaceutical composition can be prepared in any pharmaceutical dosage forms suitable for taking, preferably the pharmaceutical composition is in the form of a liquid preparation. The total effective rate of the pharmaceutical composition on treating the ulcerative colitis can reach 94%, and the pharmaceutical composition, after curing the ulcerative colitis, is low in recurrence rate.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating ulcerative colitis, a preparation method and application thereof. Background technique [0002] Ulcerative colitis (UC), referred to as ulcerative colitis, is a diffuse inflammation of the colon and rectal mucosa. Spasmodic pain, and tenesmus, can be relieved after defecation. [0003] At present, aminosalicylates and corticosteroids are mostly used in clinical treatment of ulcerative colitis, but there are shortcomings such as rebound after drug withdrawal, unstable curative effect, and large side effects of long-term medication; surgical treatment is to remove the entire colon, but Due to the many complications of surgery, it seriously affects the quality of life of patients after surgery. [0004] Therefore, there is an urgent need to find a drug that can effectively treat ulcerative colitis and reduce the burden on patients. Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61P1/00A61P1/04A61K31/198A61K31/7076A61K31/137A61K31/195A61K31/401
CPCA61K31/198A61K9/1652A61K9/4866A61K31/137A61K31/195A61K31/401A61K31/7076A61K38/05A61K2300/00
Inventor 耿福能
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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