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Absorbable bone graft material and preparation method thereof

A technology for bone implants and humerus, which is applied in the field of preparation of ergonomic materials, can solve the problems that implant materials are not easy to degrade, etc.

Inactive Publication Date: 2016-08-24
TIANJIN ZHONGJIN BIOLOGICAL DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve a series of allergic reactions caused by the enlarged carrier in the prior art and the problem that the implant material is not easy to degrade, the present invention provides an absorbable bone graft material, which has no allergic reaction and is easily absorbed Biodegradable, meeting the clinical needs for larger size carriers

Method used

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  • Absorbable bone graft material and preparation method thereof
  • Absorbable bone graft material and preparation method thereof
  • Absorbable bone graft material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] First prepare the antigen-free bovine cancellous bone carrier (BCB):

[0097] Select the cancellous bone at the upper end of the fresh bovine humerus, and cut out rectangular bone strips with a nominal size of 5mm×5mm×30mm. The tolerance requirements for the length of the strip carrier are 29±1mm, and the width and thickness are 4.5-5mm. 1 kg of the rectangular bone strips was repeatedly washed with 50°C, 0.1MPa pressure water for 4 hours, drained and then degreased with 20 L of 1:1 chloroform / methanol for 12 hours, and then degreased with 10% hydrogen peroxide for 48 hours. Use 10L of 0.6mol / L hydrochloric acid at 42°C to decalcify the surface, remove osteocytes and the endothelium of Haversian ducts for 5 minutes, and decalcify the process 4 times as needed (treat with 10L of 0.6mol / L hydrochloric acid at 42°C for 5 minutes). For bone cells and Haversian endothelium, the ash content and nitrogen content (protein content) of the BCB carrier were formulated in combinati...

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Abstract

The invention provides an absorbable bone graft material and a preparation method thereof, belonging to the field of preparation of ergonomic materials. The invention prepares BCB and BMP compositely to form a resorbable bone graft material by optimizing and adjusting the dosage of reagents and processing time in the preparation process. The BCB prepared by the present invention has no fat cells, bone cells, blood vessels and nerves in the central tube, protein components of the bone matrix, and Harvard tubes, and the composite bone graft material has no allergic reaction and is easily biodegradable, which overcomes the prior art Implant materials are prone to allergic reactions and are not easy to degrade, so they are suitable for large-scale clinical use.

Description

【Technical field】 [0001] The invention relates to a preparation method of an ergonomic material, in particular to an absorbable bone graft material and a preparation method thereof. 【Background technique】 [0002] In 1965, Urist successfully used demineralized bone matrix to induce ectopic osteogenesis in muscle, and thus discovered and determined that bone morphogenetic protein (BMP) is a member of the transforming growth factor β superfamily, which has the ability to induce undifferentiated mesenchymal The ability of mesenchymal stem cells to differentiate and proliferate toward chondrocytes and osteoblasts can promote the differentiation and maturation of osteoblasts, participate in the growth, development and reconstruction of bone and cartilage, and accelerate the repair of bone defects. BMPs were initially recognized as protein regulators of cartilage and bone formation, but they subsequently exhibited properties related to embryonic development and morphogenesis of va...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/22A61L27/58
CPCA61L27/3608A61L27/227A61L27/3687A61L27/3691A61L27/58A61L2430/02
Inventor 宋富智梁世昌宋德顺
Owner TIANJIN ZHONGJIN BIOLOGICAL DEV CO LTD
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