Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A metacycline hydrochloride pharmaceutical composition and applications thereof in biomedicines

A technology of metacycline hydrochloride and a composition, applied in the field of biomedicine, can solve the problems such as the related reports on vascular dementia of metacycline hydrochloride and the like, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-08-31
ZHENJIANG GAOHAI BIOLOGICAL PHARMA CO LTD
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between metacycline hydrochloride and its pharmaceutical composition and vascular dementia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A metacycline hydrochloride pharmaceutical composition and applications thereof in biomedicines
  • A metacycline hydrochloride pharmaceutical composition and applications thereof in biomedicines
  • A metacycline hydrochloride pharmaceutical composition and applications thereof in biomedicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Grind the dried bulbs (2kg) of Fritillaria fritillaria, extract with 90% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether ( 3L×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) Ethyl acetate extract in step (a) is removed with D101 type macroporous resin, first eluted with 35% ethanol for 8 column volumes, then with 90% ethanol for 12 column volumes, and collected 90% eluate , concentrated under reduced pressure to obtain 90% ethanol elution concentrate; (c) 90% ethanol elution concentrate in step (b) was separated with normal phase silica gel, and the volume ratio was 120:1 (11 column volumes), 60 :1 (9 column volumes), 30:1 (9 column volume...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] SD rats, half male and half male, body weight (250±20) g (Experimental Animal Center, Anhui Medical University).

[0028] 1.2 Drugs and reagents

[0029] Metacycline hydrochloride was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Dihydroergot alkaloid mesylate sustained-release capsules (trade name: Perilen, 2.5mg, Sanofi-Aventis); adenosine diphosphate (ADP, Sigma Company); thrombin (Sigma Company); epinephrine Injection (Shanghai Hefeng Pharmaceutical Co., Ltd.); Kangpaite Medical Glue (Beijing Shunkang Medical Glue Co., Ltd.); Penicillin Sodium for Injection (Zhongnuo Pharmaceutical Shijiazhuang Co., Ltd.); Gentamycin Injection (Nanjing Jinling Pharmaceutical factory); acetylcholine (Ach) assay kit (R&D Company).

[0030] 1.3 Instrume...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A metacycline hydrochloride pharmaceutical composition and applications thereof in biomedicines are disclosed. The composition comprises metacycline hydrochloride and a natural product compound (I) having a novel structure and separated from dry bulbs of fritillaria thunbergii. When the metacycline hydrochloride and the compound (I) are used separately, learning and memory capabilities of rats with synthetic vascular dementia can be significantly improved. When the metacycline hydrochloride and the compound (I) are used together, the improving effects are more obvious. The composition can be developed into a medicine treating the synthetic vascular dementia.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of metacycline hydrochloride, in particular to a pharmaceutical composition of metacycline hydrochloride and its application in biomedicine. Background technique [0002] Metacycline hydrochloride, also known as methacycline hydrochloride, methacycline, methacycline, is a semi-synthetic oxytetracycline, which is effective against G+ and G- bacteria, rickettsia, actinomycetes, and Chlamydia trachomatis , protozoa, etc. have inhibitory effect. t1 / 2=14.3h. The antibacterial performance is stronger than tetracycline, and the absorption is good. The application is the same as tetracycline. [0003] Vascular dementia (VD) is a persistent impairment of acquired intelligence that occurs on the basis of cerebrovascular diseases, mainly with memory and cognitive impairments, or with language, visual-spatial skills, and emotional or personality disorders. [0004] So far, there h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J63/00A61K31/56A61K31/65A61P25/28
CPCC07J63/008A61K31/56A61K31/65A61K36/8967A61K2300/00
Inventor 潘立李义高李小彪赵阳
Owner ZHENJIANG GAOHAI BIOLOGICAL PHARMA CO LTD
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com