A kind of preparation method of self-adhesive conductive hydrogel

A conductive hydrogel and self-adhesive technology, which is applied in the field of preparation of self-adhesive conductive hydrogel, can solve problems such as increased complexity, achieve good biocompatibility, improve hydrophilicity, and increase dispersibility Effect

Active Publication Date: 2018-08-24
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing conductive hydrogels need to rely on additional adhesives during use, increasing the complexity of use

Method used

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  • A kind of preparation method of self-adhesive conductive hydrogel
  • A kind of preparation method of self-adhesive conductive hydrogel
  • A kind of preparation method of self-adhesive conductive hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0041] A, preparation of double-bonded silk fibroin:

[0042] A1: Weigh silk fibroin and dissolve it in water to prepare a solution with a concentration of 2%;

[0043] A2: Slowly add methacrylic anhydride 0.8 times the amount of silk fibroin into the biomacromolecule solution, and then stir and react at 50°C for 24 hours;

[0044] A3: Dilute the reaction solution of silk fibroin and methacrylic anhydride 5 times;

[0045] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12-14 kDa, and dialyze with deionized water to obtain a double-bonded silk fibroin solution;

[0046] A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at 2500rpm for 15 minutes, and freeze-dry the obtained centrifuged precipitate to obtain double-bonded silk fibroin powder.

[0047] B. Preparation of polydopamine-functionalized conductive nanomateri...

Embodiment 2

[0055] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0056] A, prepare double-bonded chitosan:

[0057] A1: Take chitosan and dissolve it in phosphate buffer solution to prepare a solution with a mass concentration of 1%;

[0058] A2: Slowly add methacrylic anhydride 0.16 times the mass of chitosan to the biomacromolecule solution dropwise, then stir and react at 25°C for 24 hours;

[0059] A3: subsequently dilute the reaction solution of chitosan biomacromolecule and methacrylic anhydride 5 times;

[0060] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12 to 14 kDa, and dialyze with deionized water to obtain a double-bonded chitosan solution;

[0061] A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at a speed of 2500 rpm for 15 minutes, and freeze-dry the resulting centrifuged precipitate to obtain a double-bonded chitosan powder.

[0062] B. Preparation of poly...

Embodiment 3

[0070] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0071] A. Preparation of double bonded gelatin:

[0072] A1: Weigh gelatin and dissolve it in phosphate buffer solution to obtain a solution with a gelatin mass concentration of 10%;

[0073] A2: Slowly add glycidyl methacrylate 17.5 times the mass of gelatin to the biomacromolecule solution dropwise, then stir and react at 50°C for 3 hours;

[0074] A3: Then dilute the reaction solution of gelatin and methacrylic anhydride 5 times;

[0075] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12-14 kDa, and dialyze with deionized water to obtain a double-bonded gelatin solution;

[0076] A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at 2500 rpm for 15 minutes, and freeze-dry the resulting centrifuged precipitate to obtain double-bonded gelatin powder.

[0077] B. Preparation of polydopamine-functionalized conducti...

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Abstract

The invention discloses a preparation method of self-adhesive conductive hydrogel, which belongs to the technical field of biological material preparation. The invention comprises the following steps: firstly, introducing double bonds on biomacromolecules through methacrylic anhydride to obtain double bonded biomacromolecules. Then polydopamine functionalized conductive nanomaterials are prepared, and finally the self-adhesive conductive hydrogel is prepared by photoinitiating free radical polymerization of the double-bonded biomacromolecule and the polydopamine functionalized conductive nanomaterials. The invention learns from the adhesion of imitation mussel materials, introduces adhesive phenolic hydroxyl functional groups, and realizes the regulation and control of hydrogel self-adhesive performance by changing the content of the phenolic hydroxyl functional groups. In addition, the self-adhesive conductive hydrogel prepared by the present invention has good electrical conductivity, mechanical properties and biocompatibility, which broadens the application range of the hydrogel; the preparation method of the present invention is simple and easy, and the polymerization process is controllable , fast polymerization, low energy consumption and other advantages.

Description

technical field [0001] The invention belongs to the technical field of biomaterial preparation, and in particular relates to a preparation method of a self-adhesive conductive hydrogel with good mechanical properties, electrical conductivity and biocompatibility. Background technique [0002] Smart hydrogels are a class of hydrogels that can respond to changes in external stimulus signals (such as temperature, pH, solvent, ionic strength, electric field, magnetic field, pressure, and specific molecules, etc.). Conductive hydrogel is a kind of smart hydrogel. It combines the dual characteristics of hydrogel and conductive material, and has a controllable conductivity range. Therefore, it is widely used in artificial electronic skin, wearable bioelectronic devices, and cardiac tissue engineering. There are potential applications in areas such as materials and biosensors. [0003] At present, conductive hydrogels are mainly composed of conductive nanoparticles or conductive po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08G81/00C08F289/00C08F251/00C08L79/04C08K3/04
CPCC08F251/00C08F289/00C08G81/00C08G2210/00C08J3/075C08J2387/00C08J2479/04C08K3/04C08K2201/001C08K2201/011C08F220/08
Inventor 鲁雄韩璐甘东林刘柯志王振铭谢超鸣
Owner SOUTHWEST JIAOTONG UNIV
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