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Implanted flexible neural electrode based on liquid metal and production method

A liquid metal, implantable technology, used in electrodes, internal electrodes, head electrodes, etc., can solve problems such as strong toxicity and incompatibility, achieve good mechanical properties, good biocompatibility, and prevent liquid metal leakage. Effect

Active Publication Date: 2016-09-21
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although mercury can remain liquid at room temperature, it is highly toxic and not suitable for use in the human body

Method used

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  • Implanted flexible neural electrode based on liquid metal and production method
  • Implanted flexible neural electrode based on liquid metal and production method
  • Implanted flexible neural electrode based on liquid metal and production method

Examples

Experimental program
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preparation example Construction

[0061] The preparation method of the liquid metal-based implantable flexible nerve electrode provided by the present invention includes the following operations:

[0062] 1) Mix the polymer reaction solution and curing agent at a mass ratio of 5 to 15:1 to obtain a polymer film forming agent, and then spread it evenly on the surface of the mold or pour it into the mold, and heat the polymer film forming agent Solidification, resulting in a flexible polymer film;

[0063] 2) Cover the mask plate on the flexible polymer film, and use the liquid metal spray gun to evenly spray the liquid metal on the flexible polymer film; then remove the mask plate, and clean the excess liquid metal droplets outside the mask plate , the liquid metal circuit on the flexible polymer film is completed;

[0064] 3) using a puncher to punch a through hole corresponding to the position of the electrode end of the liquid metal circuit on another flexible polymer film, and then tightly bonding the flex...

Embodiment 1

[0068] see Picture 1-1 , figure 2 As shown, the array central nerve electrode 1 is mainly composed of three parts: a flexible polymer film 3 , a liquid metal circuit 4 and a liquid metal encapsulant 5 . Flexible polymer film 3 overall shape is long 3cm, the rectangle of wide 2cm, is divided into upper and lower two layers: the lower layer is the thick polymer film of 100 microns; 500 µm vias. The liquid metal circuit 4 is located in the middle of the upper and lower polymer films. The 25 electrode terminals of the liquid metal circuit correspond to the through holes of the upper film, and the 25 terminals on the other side of the circuit line are all distributed on the side of the polymer film. An interface end is formed to facilitate connection with an external circuit interface. The liquid metal encapsulant 5 is poured into the 25 vias on the polymer film. The compound is a solid jelly, which can encapsulate the liquid metal circuit to prevent leakage; the doped liquid ...

Embodiment 2

[0071] see Figure 1-2 , Figure 4 , the structure of the cuff-type peripheral nerve electrode is similar to that of the array-type central nerve electrode 1 , and mainly consists of three parts: a flexible polymer film 3 , a liquid metal circuit 4 and a liquid metal encapsulant 5 . The flexible polymer film 3 has a three-dimensional spatial structure. The front section is a slender circular arc formed by bending a rectangular film with a width of 4mm and a length of 1cm, and a rear section is a strip-shaped film with a width of 2mm and a length of 5cm. The flexible polymer film 3 is also divided into upper and lower layers, the lower layer is a polymer film with a thickness of 100 microns; the upper layer is a polymer film with a thickness of 100 microns. A through hole with a diameter of 500 microns is distributed in the front section of the upper film. The liquid metal circuit 4 is located between the upper and lower polymer films, and the electrode terminals of the circu...

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Abstract

The invention discloses an implanted flexible neural electrode based on liquid metal. The implanted flexible neural electrode comprises a liquid metal circuit, which is disposed between flexible polymer thin films in a packaged manner. The flexible polymer thin films are provided with through holes communicated with the liquid metal circuit, and conductive liquid metal packaging agent is disposed in the through holes in a packaged manner, and is polymer thin film forming agent doped with the liquid metal. The completed flexibility of the implanted neural electrode is realized, and a conventional platinum electrode is replaced. The liquid metal has good conductivity, excellent compliance, and special fluidity, and therefore the unique advantages of the liquid metal used for the production of the flexible biological electrodes are provided. Compared with conventional rigid neural electrodes, the implanted flexible neural electrode based on the liquid metal has better biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of implantable nerve electrodes, and relates to a liquid metal-based implantable flexible nerve electrode and a preparation method thereof. Background technique [0002] The nervous system is an essential and important part of the human body, carrying a variety of important physiological functions. With the deepening of understanding in the field of cell and molecular biology, people can study the nervous system from different structural levels. The nervous system plays a vital role in the human body, so problems with either the central nervous system or the peripheral nervous system will have a very serious impact on people's daily life. There are many nervous system diseases, common central nervous system diseases include epilepsy, Alzheimer's disease, Parkinson's disease, drug dependence, sleep disorders, mental disorders, etc.; common peripheral nervous system diseases are generally nerve pinch, nerve r...

Claims

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Application Information

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IPC IPC(8): A61N1/05
CPCA61N1/05A61N1/0529
Inventor 国瑞盛磊刘静
Owner TSINGHUA UNIV
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