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Medicinal composition of dihydroartemisinin and application of medicinal composition of dihydroartemisinin in biological medicine

A technology of dihydroartemisinin and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve the problems that have not yet been reported related to dihydroartemisinin, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-09-21
陈露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between dihydroartemisinin and its pharmaceutical composition and emphysema

Method used

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  • Medicinal composition of dihydroartemisinin and application of medicinal composition of dihydroartemisinin in biological medicine
  • Medicinal composition of dihydroartemisinin and application of medicinal composition of dihydroartemisinin in biological medicine
  • Medicinal composition of dihydroartemisinin and application of medicinal composition of dihydroartemisinin in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0018] Separation method: (a) Grind Adenophora (2kg), extract with 90% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract in the medium, first elute with 35% ethanol for 8 column volumes, then use 90% ethanol to elute for 12 column volumes, collect 90% eluent, and depressurize Concentrate to get 90% ethanol elution concentrate; (c) in step (b), 90% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 120:1 (11 column volumes), 60:1 ( 9 column volumes), 30:1 (9 column volumes) and 15:1...

Embodiment 2

[0021] Embodiment 2: pharmacological action

[0022] In this embodiment, a rat model of emphysema was prepared by injecting 750UkgBW of elastase into the trachea once, and the anti-emphysema effect of the drug on improving the total lung volume (TVL), average alveolar area, and fiber cross-sectional area of ​​the animal was observed.

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] SD rats aged 8-10 weeks, half male and half male, weighing 170-190 g. Provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. Experimental animal facility conditions: Animal Observation Room, School of Pharmacy, Chengdu University of Traditional Chinese Medicine.

[0026] 1.2 Reagents and samples

[0027] Dihydroartemisinin was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1.

[0028] 1.3 Instruments

[0029] An IEICa Q50...

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Abstract

The invention discloses a medicinal composition of dihydroartemisinin and an application of the medicinal composition of dihydroartemisinin in a biological medicine. The medicinal composition of dihydroartemisinin provided by the invention comprises dihydroartemisinin and a natural product with a novel structure, namely a compound (I), when each of dihydroartemisinin and the compound (I) acts independently, a therapeutic effect on emphysema is generated; when dihydroartemisinin and the compound (I) are in combined action, the therapeutic effect on the emphysema can be further improved, so that dihydroartemisinin and the compound (I) can be developed into the medicine for treating the emphysema. Compared with the prior art, the medicinal composition of dihydroartemisinin and the application of dihydroartemisinin in the biological medicine have prominent substantive features and obvious progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of dihydroartemisinin, in particular to a pharmaceutical composition of dihydroartemisinin and its application in biomedicine. Background technique [0002] Dihydroartemisinin is a derivative of artemisinin, which has a strong and rapid killing effect on the erythrocytic stage of Plasmodium, and can quickly control clinical attacks and symptoms. The mechanism of action of artemisinin is not very clear, mainly to interfere with the mitochondrial function of the surface membrane of Plasmodium. Artemisinin changes the membrane structure of Plasmodium by affecting the ultrastructure of the erythrocytic stage of Plasmodium. Due to the effect on the food bubble membrane, the nutrient intake of the malaria parasite is blocked. When the malaria parasite loses a large amount of cytoplasm and nutrients and cannot be supplemented, it will die soon. [0003] So far, there has been...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93A61K31/365A61K31/357A61P11/00
CPCC07D307/93A61K31/357A61K31/365A61K36/23
Inventor 陈露
Owner 陈露