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Quantum dot-polypeptide compound with linear polycaprolactone joint arm

A technology of polypeptide complexes and polycaprolactone, which is applied in the fields of peptides, peptide sources, viral peptides, etc., can solve the problems of unreported quantum dot complexes.

Inactive Publication Date: 2016-09-28
安徽红太阳新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

See the above process figure 1 , the present invention is not limited to the caprolactone monomer structure in Formula 1, wherein R is a basic group, and this type of quantum dot complex has not been reported so far

Method used

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  • Quantum dot-polypeptide compound with linear polycaprolactone joint arm
  • Quantum dot-polypeptide compound with linear polycaprolactone joint arm
  • Quantum dot-polypeptide compound with linear polycaprolactone joint arm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Synthesis of Adhesive Antigen-8-unit Caprolactone-Quantum Dot Complex of Porcine Enterotoxin-derived Escherichia coli K88ac: 6-methylene imidazole caprolactone was selected as the caprolactone monomer.

[0031]

[0032] Mix 0.01mol of porcine enterotoxin-derived Escherichia coli K88ac adhesion antigen and 0.08mol of 6-methylene imidazole caprolactone in DMF solution, slowly adjust the pH to 8.0, stir at room temperature for 2 hours, and pour the reaction solution into n-hexane A white colloidal solid was precipitated out, and the filter cake was vacuum-dried after filtration.

[0033] CdSe / ZnS shell quantum dots were selected and dispersed in phosphate buffer at room temperature with a quantum dot concentration of 0.1mol / L. Use N-hydroxysulfosuccinic acid imide as the activator at a concentration of 20 mol / L, react on a shaking table at room temperature for 1 hour, wash with neutral acetonitrile to remove excess activator. Add the antibody polypeptide chain-caprolac...

Embodiment 2

[0035] Synthesis of hepatitis B virus core antigen-300 unit caprolactone arm-quantum dot complex: 5-methylenethiazole caprolactone is selected as the caprolactone monomer.

[0036]

[0037] Mix 0.001 mol of hepatitis B virus core antigen and 0.30 mol of 5-methylenethiazol caprolactone in water / acetonitrile solution, slowly adjust the pH to 8.0, stir at room temperature for 2 hours, pour the reaction solution into n-hexane to precipitate white Gummy solid, filter and dry the filter cake in vacuo.

[0038] CdSe / ZnS shell quantum dots were selected and dispersed in phosphate buffer at room temperature with a quantum dot concentration of 0.1mol / L. Use N-hydroxysulfosuccinic acid imide as the activator at a concentration of 20 mol / L, react on a shaking table at room temperature for 1 hour, wash with neutral acetonitrile to remove excess activator. Add the above-mentioned phosphate buffer, and centrifuge the resulting reaction product at a speed of 5,000 rpm in a high-speed cent...

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Abstract

The invention relates to a quantum dot-polypeptide compound with linear polycaprolactone joint arm. Polypeptide with terminal amino group is used as an initiator to initiate ring opening polymerization of epsilon-caprolactone monomer with ring having a basic group. The basic group is selected from guanidine group, pyrazolyl group, imidazole group, thiazolyl group, pyridine group, quinolyl group, isoquinolyl group, pyrimidyl group, 1,2,4-triazine or purine group. Through ester exchange type ring opening polymerization, covalent coupling of linear polycaprolactone and functional polypeptide is realized, and the basic group at the side chain of polycaprolactone is chelated with a quantum dot shell to form the quantum dot-polypeptide compound. The invention belongs to the field of organic chemistry.

Description

technical field [0001] The invention belongs to the field of organic chemistry, in particular to a quantum dot-polypeptide compound with linear polycaprolactone linking arms. Background technique [0002] In the context of serious environmental problems and shortage of petroleum resources, biodegradable plastics have received widespread attention. Among them, polycaprolactone has become a hot spot for research and development. Polycaprolactone is polymerized from ε-caprolactone monomer and is a hydrophobic, semi-crystalline polymer. Its crystallinity decreases with the molecular weight of the polymer, and the polymer can be degraded under the action of microorganisms. The raw material of the polycaprolactone industry is a renewable biological material, and the final products of its degradation are also water and carbon dioxide, which can be completely biodegraded. It is one of the most competitive biodegradable materials and is widely used in biomedicine field. [0003] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/13C09K11/02C09K11/88
CPCC07K1/13C07K14/005C07K14/245C09K11/02C09K11/883C12N2730/10122
Inventor 郭畅唐定良陈永福诸江徽张开炳
Owner 安徽红太阳新材料有限公司