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Compound preservative containing glycerol caprylate and decoyl hydroximic acid and preparation method of c ompound preservative

A technology of caprylyl hydroxamic acid and glycerol caprylate, applied in the field of preservatives, can solve the problems of difficult cosmetic production, weak bacteriostatic effect, easy crystallization and hanging on the wall, etc. The effect of product stability

Active Publication Date: 2016-10-12
广州艾卓生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, caprylyl hydroxamic acid also has a relatively single antibacterial spectrum, and the antibacterial effect is weak when used alone; caprylyl hydroxamic acid is easy to crystallize and hang on the wall in the solution, which brings certain difficulties to the production of cosmetics

Method used

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  • Compound preservative containing glycerol caprylate and decoyl hydroximic acid and preparation method of c ompound preservative
  • Compound preservative containing glycerol caprylate and decoyl hydroximic acid and preparation method of c ompound preservative
  • Compound preservative containing glycerol caprylate and decoyl hydroximic acid and preparation method of c ompound preservative

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Experimental program
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Effect test

preparation example Construction

[0036] The preparation method of this compound preservative comprises the steps:

[0037] 1) Add caprylyl hydroxamic acid into the reaction kettle, then add diol, stir and heat to 45°C-50°C, and keep stirring within this temperature range until caprylyl hydroxamic acid is completely dissolved;

[0038] 2) Add glyceryl caprylate into the reaction kettle in step 1), stir until glyceryl caprylate and caprylyl hydroxamic acid are evenly mixed, cool to room temperature, and fill.

Embodiment 1

[0040] The present invention has verified that glyceryl caprylate (GMCY) and caprylyl hydroxamic acid (CHA) are effective against Escherichia coli, Pseudomonas aeruginosa, Pseudomonas putida, Burdock cepacia, Staphylococcus aureus by adopting the inhibition zone experiment. , Aspergillus niger, and Candida albicans, the synergistic effect of the 7 mixed bacteria, the larger the diameter of the inhibition zone, the more obvious the antibacterial effect. Table 1 is the verification result:

[0041] Table 1 Experiment data record of inhibition zone

[0042] Element

Bacterial inhibition zone (mm)

Fungal inhibition zone (mm)

blank

——

——

GMCY (1%)

4

2

GMCY (7%)

6

2

GMCY (15%)

11

6

CHA (1%)

9

7

CHA (7%)

12

12

CHA (10%)

16

14

CHA (15%)

19

17

GMCY+CHA(0.5%+0.5%)

8

5

GMCY+CHA(1%+1%)

14

11

GMCY+CHA(5%+5%)

16

13

GMCY+CHA(5%+...

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Abstract

The invention discloses a compound preservative containing glycerol caprylate and decoyl hydroximic acid and a preparation method of. The compound preservative is characterized by being prepared from the following ingredients in percentage by weight: 0.5%-15% of caprylin, 1%-15% of the decoyl hydroximic acid and 70-98.5% of dihydroxy alcohol. The compound preservative has favorable antibacterial effects on gram-positive bacteria, gram-negative bacteria, mold, microzyme and the like, and can be used for improving the product stability.

Description

technical field [0001] The invention relates to the field of preservatives, in particular to a compound preservative containing glyceryl caprylate and caprylyl hydroxamic acid and a preparation method thereof. Background technique [0002] Glyceryl caprylate is a widely used additive in the food industry, which can improve the taste of food and provide special mouthfeel. At the same time, glyceryl caprylate is also a nutrient that naturally exists in milk. As the use of glyceryl caprylate becomes more and more common and the scope is wider and wider, some new properties of this substance are gradually known to people. Bacteriostasis is one of its characteristics, but its bacteriostasis ability is relatively general, and it is not suitable for microorganisms. There are differences in the inhibition of bacterial species, for example, the inhibition of Gram-positive bacteria is better than that of Gram-negative bacteria. And when the concentration of glyceryl caprylate exceed...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/42A61K8/34A61Q19/00
CPCA61K8/345A61K8/375A61K8/42A61K2800/524A61K2800/592A61Q19/00
Inventor 张晓琮张军
Owner 广州艾卓生物科技股份有限公司
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