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Water-soluble gynecological gel and preparation method thereof

A water-soluble, gynecological technology, applied in the direction of diseases, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of breaking the vaginal environmental balance, destroying the vaginal micro-ecological environment, and poor curative effect, so as to improve the emulsification and dispersion effect and sterilize Good effect and easy absorption effect

Active Publication Date: 2019-05-14
GUIZHOU JINJIU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing gynecological treatment drugs contain drug bactericidal ingredients. Although they can kill or inhibit the vaginal flora, they will also kill the dominant flora Lactobacillus in the vagina, destroying the micro-ecological environment in the vagina and breaking the vagina. internal environment balance
Moreover, these drugs are expensive and have poor efficacy

Method used

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  • Water-soluble gynecological gel and preparation method thereof

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preparation example Construction

[0020] A preparation method of a water-soluble gynecological gel, firstly, hydroxypropyl cellulose is swollen in water to make a transparent swelling liquid, in the swelling liquid, the weight ratio of hydroxypropyl cellulose to water is preferably 1:15-18, The weight ratio of hydroxypropyl cellulose to water is more preferably 1:16-17. Under the preferred weight ratio of hydroxypropyl cellulose to water, the hydroxypropyl cellulose can fully swell, and the hydroxypropyl cellulose can be dispersed more uniformly. Preferably, the weight ratio of hydroxypropyl cellulose to water is 3:50, the swelling ratio is the optimal ratio, the prepared swelling liquid is uniformly dispersed and the viscosity of the swelling liquid is more suitable. After being made into gynecological gel, it is not easy to flow, and it is more convenient to apply and use. Here, room temperature means 15°C to 25°C. When preparing the swelling solution, it needs to be left at room temperature for a period o...

Embodiment 1

[0026] Weigh 3% hypromellose of the total amount of pre-production products, add 50% of the total amount of pre-production products purified water, stir it to make it fully dispersed and wet, and let it fully swell for 10 hours to make a swelling solution. The weight ratio of hypromellose to water in the liquid is 3:50, and it is set aside.

[0027] In addition, take by weighing 0.2% methylparaben of the total amount of pre-production products, add 30% purified water of the total amount of pre-production products and stir to make it completely dissolved into an aqueous solution, the weight percent of methylparaben in the aqueous solution is 0.67%, and set aside.

[0028] Use a vacuum pump to suck all the swollen hypromellose swelling liquid into the emulsification tank; then add 2% glycerin and methyl paraben aqueous solution of the total amount of pre-production products, add purified water to the total amount of pre-production products, and start the vacuum For the emulsifyi...

Embodiment 2

[0031] Weigh 2% hypromellose of the total amount of pre-production products, add 30% of the total amount of pre-production products purified water, stir it to make it fully dispersed and wet, and let it fully swell for 15 hours to make a swelling solution. The weight ratio of hypromellose to water in the liquid is 1:15, and it is set aside.

[0032] In addition, take by weighing 0.4% methylparaben of the total amount of pre-production products, add 57% of purified water of the total amount of pre-production products and stir to make it completely dissolved into an aqueous solution, and the weight percent of methyl paraben in the aqueous solution is 0.7%, for subsequent use.

[0033] Use a vacuum pump to suck all the swollen hypromellose swelling solution into the emulsification tank; add 1.5% glycerin and methyl paraben aqueous solution to the total amount of pre-production products, add purified water to the total amount of pre-production products, and start the vacuum For th...

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Abstract

The invention belongs to the field of gynecological medicines and provides water-soluble gynecological gel. The water-soluble gynecological gel is prepared from, by weight, 2%-5% of hydroxypropyl cellulose, 0.05%-0.5% of methylparaben, 1%-5% of glycerin and the balance water. The water-soluble gynecological gel is thick liquid, moderate in viscosity, free of flowing, intrinsically colorless, free of pungent smell and longer than 12 hours in effective acting time and is naturally excreted along with vaginal secretion. In addition, the water-soluble gynecological gel is better in bactericidal effect and free of side effects on human bodies.

Description

technical field [0001] The invention relates to the field of gynecological medicines, and in particular to a water-soluble gynecological gel and a preparation method thereof. Background technique [0002] Reproductive tract infection is a "stealth killer" that seriously endangers women's health. The root cause of reproductive tract infection is various opportunistic pathogenic bacteria that are prone to lurk in the internal and external genitals, such as staphylococcus, streptococcus, E. coli, anaerobic bacteria , Sexually transmitted pathogens, Candida albicans, Mycoplasma, Chlamydia, etc. [0003] Most of the existing gynecological treatment drugs contain drug bactericidal ingredients. Although they can kill or inhibit the vaginal flora, they will also kill the dominant flora Lactobacillus in the vagina, destroying the micro-ecological environment in the vagina and breaking the vagina. balance of the internal environment. And this class medicine is expensive, and curativ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/216A61K47/38A61P15/02A61P31/04A61P31/10
CPCA61K9/0034A61K9/06A61K31/216A61K47/38
Inventor 韩克兵肖可郎涛陈治国张亚林
Owner GUIZHOU JINJIU BIOTECH
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