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Vanillin microcapsule droplets and preparing method thereof

A vanillin and microcapsule technology, applied in the field of vanillin microcapsule droplets and their preparation, can solve the problem of the controllability of vanillin particle size and morphology is relatively few, inconvenient to use directly, water-soluble It has the effect of increasing pharmacological function, increasing diversity and good biocompatibility.

Inactive Publication Date: 2016-10-12
HUIZHOU RES INST OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, vanillin itself has defects: poor water solubility, and it is easy to lose its activity when exposed to air and light, making it inconvenient to use directly
[0003] Conventionally, there are many influencing factors (such as stirring speed, reaction time, reaction temperature, pH, etc.), and domestic and foreign scholars have relatively little research on the controllability of vanillin particle size and morphology

Method used

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  • Vanillin microcapsule droplets and preparing method thereof
  • Vanillin microcapsule droplets and preparing method thereof
  • Vanillin microcapsule droplets and preparing method thereof

Examples

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Effect test

Embodiment 1

[0033] The process of preparing vanillin / chitosan microsphere droplets by microfluidics: take 0.5g vanillin and dissolve it in 10ml benzyl benzoate and add 0.1g natural extract curcumin to it to color the core material, As L1, take 20ml pre-configured chitosan-acetic acid solution with a pH of 6.5~6.8 as L2. The port size of the constant internal fluid phase is 120 μm, the linear velocity of L1 is adjusted to 215 μm / min, and the linear velocity of L2 is 719 μm / min. L1 and L2 meet at the small hole of the microfluidic device to form a vanillin / chitosan microsphere solution drop.

[0034] Gained vanillin microcapsule liquid drop sees figure 2 According to the microscope picture, the particle size of the obtained microemulsion system is 340 μm.

Embodiment 2

[0036] The process of preparing vanillin / chitosan microsphere droplets by microfluidics: take 0.5g vanillin and dissolve it in 10ml benzyl benzoate and add 0.1g natural extract curcumin to it to color the core material, As L1, take 20ml pre-configured chitosan-acetic acid solution with a pH of 6.5~6.8 as L2. The port size of the constant internal flow phase is 120 μm, the linear velocity of L1 is adjusted to 215 μm / min, and the linear velocity of L2 is 899 μm / min. L1 and L2 meet in the small hole of the microfluidic device to form a vanillin / chitosan microsphere solution drop.

[0037] Gained vanillin microcapsule liquid drop sees image 3 According to the microscope picture, the particle size of the obtained microemulsion system is about 270 μm.

Embodiment 3

[0039] The process of preparing vanillin / chitosan microsphere droplets by microfluidics: take 0.5g vanillin and dissolve it in 10ml benzyl benzoate and add 0.1g natural extract curcumin to it to color the core material, As L1, take 20ml pre-configured chitosan-acetic acid solution with a pH of 6.5~6.8 as L2. The port size of the constant internal flow phase is 120 μm, the linear velocity of L1 is adjusted to 215 μm / min, and the linear velocity of L2 is 1799 μm / min. L1 and L2 meet in the small hole of the microfluidic device to form a vanillin / chitosan microsphere liquid drop.

[0040] Gained vanillin microcapsule liquid drop sees Figure 4 According to the microscopic image, the particle diameter of the obtained microemulsion system is 246 μm.

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Abstract

The invention discloses vanillin microcapsule droplets and a preparing method thereof. The vanillin microcapsule droplets are prepared through the following steps that 1, vanillin is taken and dissolved in solvent to prepare a core material solution serving as fluid L1; 2, chitosan is taken and dissolved in a glacial acetic acid water solution, and the pH value is adjusted to 6.5-6.8 to prepare a wall material solution serving as fluid L2; 3, L1 and L2 pass through a microfluidic device to prepare the vanillin microcapsule droplets. By adopting the microfluidic technology, the laminar flow characteristics of the fluid in microchannels are used, the particle size of the vanillin microcapsule droplets can be controlled by fixing core material L1 flow speed and adjusting wall material L2 flow speed, the vanillin microcapsule droplets are arrayed in the channels in order, and the vanillin microcapsule droplets with the particle size uniform and controllable are obtained.

Description

technical field [0001] The invention relates to a vanillin microcapsule droplet and a preparation method thereof. Background technique [0002] Vanillin is a solid spice with a strong milky aroma. It is widely used in food, pharmaceutical intermediates, and daily cosmetics at home and abroad. However, vanillin itself has defects: poor water solubility, and it is easy to lose its activity when exposed to air and light, so that it is inconvenient to use directly. However, microencapsulation of vanillin can greatly improve the various performances of vanillin and greatly increase its application range. [0003] Conventionally, there are many influencing factors (such as stirring speed, reaction time, reaction temperature, pH, etc.), and there are relatively few studies on the controllability of vanillin particle size and morphology by domestic and foreign scholars. Contents of the invention [0004] The purpose of the present invention is to overcome the deficiencies of th...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/11A61K31/12A61K47/10
CPCA61K9/5036A61K31/11A61K31/12A61K47/10A61K2300/00
Inventor 纪红兵黄丽云易丹
Owner HUIZHOU RES INST OF SUN YAT SEN UNIV
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