Compound sea cucumber preparation and preparation method thereof

A sea cucumber and preparation technology, applied in the field of pharmaceutical preparations, can solve the problems of unclear target population and unclear effect, and achieve the effect of improving pharmacological function

Inactive Publication Date: 2012-01-25
DALIAN HAIYANTANG BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Sea cucumber compound preparations are basically blank in the market at present. There are only a few such as patent 200710114414.7 compound sea cucumber glycopeptide oral liquid, which is a compound sea cucumber oral liquid developed by using sea cucumbers, royal jelly and traditional Chinese medicine extracts. Clear, the effect is not clear

Method used

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  • Compound sea cucumber preparation and preparation method thereof
  • Compound sea cucumber preparation and preparation method thereof
  • Compound sea cucumber preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Raw material processing: cut open the fresh sea cucumber, take out the viscera, fully clean the body wall of the sea cucumber respectively, and place them in an airtight container.

[0023] (2) Gelling: Heat the above container at 70-80°C for 20h.

[0024] (3) Vacuum freeze-drying: the gelatinized sea cucumber is freeze-dried, and the water content is 0.1%.

[0025] (4) Coarse crushing: coarsely crushing the freeze-dried sea cucumber. Sea cucumber powder with a fineness ranging from 10 to 300 meshes is obtained.

[0026] (5) Superfine pulverization: the coarsely pulverized sea cucumber powder is pulverized by a jet mill to obtain superfine sea cucumber powder with a pulverization fineness of 100-3000 mesh.

[0027] (6) Nano-grinding: the sea cucumber superfine powder that has been jet-milled is nano-pulverized with a high-energy ball mill, and the milling time is 4 hours.

[0028] (7) Enzymolysis: add nano-sea cucumber powder and water (weight ratio) according to...

Embodiment 2

[0034] (1) Raw material processing: Cut open the fresh and live ginseng, take out the viscera, fully clean the body wall and viscera of the sea cucumber respectively, and put them together in an airtight container.

[0035] (2) Gelling: Heat the above container at 80-90°C for 15 hours.

[0036] (3) Vacuum freeze-drying: the gelatinized sea cucumber is freeze-dried, and the water content is 1%.

[0037] (4) Coarse crushing: coarsely crushing the freeze-dried sea cucumber. Sea cucumber powder with a fineness ranging from 10 to 300 meshes is obtained.

[0038] (5) Superfine pulverization: the coarsely pulverized sea cucumber powder is pulverized by a jet mill to obtain superfine sea cucumber powder with a pulverization fineness of 100-3000 mesh.

[0039] (6) Nano-grinding: the air-jet milled superfine sea cucumber powder is nano-pulverized with a high-energy ball mill, and the milling time is 8 hours.

[0040] (7) Enzymolysis: After adding nano-sea cucumber powder and water (w...

Embodiment 3

[0046] (1) Raw material processing: take dried sea cucumber, soak it in water until soft, cut off the body wall, clean it, and put it in an airtight container.

[0047] (2) Gelling: Heat the above container at 90-100°C for 10 hours.

[0048] (3) Vacuum freeze-drying: the gelatinized sea cucumber is freeze-dried, and the water content is 3%.

[0049] (4) Coarse pulverization, (5) Superfine pulverization and (6) Nano pulverization are the same as in Example 2.

[0050] (7) Enzymolysis: After adding nano-sea cucumber powder and water (weight ratio) according to the ratio of 1:5, stir well, add trypsin according to the mass ratio of nano-sea cucumber powder and trypsin 1g: 10mg, pH8~9, The enzymolysis temperature is 45° C., and after the enzymolysis is performed for 5 hours, the enzymolysis reaction solution is heated at 100° C. for 10 minutes after the end of the enzyme reaction. Centrifuge the enzymatic hydrolysis product, take the enzymatic hydrolysis supernatant, and directl...

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Abstract

The invention relates to a compound sea cucumber preparation and a preparation method thereof. The preparation method comprises the following steps: cutting off and cleaning fresh and live sea cucumbers or water-soaked sea cucumbers, putting in a closed container, gelling at 70-130 DEG C for 1 minutes-20 hours, carrying out freeze drying until the water content is less than 10 wt%, and sequentially carrying out coarse, ultrafine and nano crushing until the fineness is 10-1000 nm; adding water to the nano sea cucumber powder to perform protease enzymolysis, deactivating enzymes after the enzymolysis, separating, and drying the supernate to obtain a nano sea cucumber extract; and evenly mixing the nano sea cucumber extract with a panax notoginsen saponin extract according to a ratio of 99-70%:1-30%. In the compound sea cucumber preparation, the sea cucumber polysaccharide content is 2.5-8.0 wt%, and the panax notoginsen saponin content is 0.3-21.0 wt%. The compound preparation can achieve pharmacologically complementary and synergetic effects, and side effects of any simplex agent are eliminated by the complexing agent mode, thereby greatly improving the pharmacological function of any simplex component of sea cucumbers or notoginseng. The compound preparation can be used for multiple medical purposes, such as anticoagulation, diabetes treatment and the like.

Description

technical field [0001] The invention belongs to extracts derived from molluscs and medicinal preparations of plants, and relates to the application of enzymes, the extraction technology of polysaccharides, and the preparation of dosage forms of preparations. Background technique [0002] Sea cucumber is one of the eight delicacies of seafood in my country, and its nourishing value is recognized by people. Among them, sea cucumber polysaccharide is the most important active ingredient in sea cucumber, which has a variety of physiological activities. According to experimental studies, sea cucumber polysaccharide has a significant effect on combating cardiovascular and cerebrovascular diseases. After the sea cucumber is nano-sized, it can be directly developed, which can not only make full use of important active ingredients such as sea cucumber polysaccharides, but also make full use of sea cucumber proteins, lipids and other components. [0003] Panax notoginseng is a ginsen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K35/56A61P3/10A61P7/02A61P9/10A61K35/616
CPCA61K2236/39A61K35/616A61K35/56A23L1/30A61K36/258A61P3/10A61P7/02A61P9/00A61P9/10A61K2300/00
Inventor 焦健邵俊杰
Owner DALIAN HAIYANTANG BIOLOGY
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