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Pig brain extract, composition containing pig brain extract and application of composition

A technology for extracts and compositions, which is applied to medical preparations containing active ingredients, drug combinations, applications, etc., can solve the problems of limited effect and obvious side effects, and achieves the effect of simple method and reduced number of errors.

Active Publication Date: 2016-10-12
HANGZHOU HUAJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the drugs used to treat AD diseases are chemical drugs, which have obvious side effects and relatively limited effects. Therefore, it is of great significance to use pig brain as a material to develop products with brain-enhancing and intellectual-enhancing effects.

Method used

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  • Pig brain extract, composition containing pig brain extract and application of composition
  • Pig brain extract, composition containing pig brain extract and application of composition
  • Pig brain extract, composition containing pig brain extract and application of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0063] The preparation of embodiment 1 pig brain extract

[0064] Healthy pig brains were taken, cleaned and removed of connective tissue, then frozen and homogenized.

[0065] For every 1000 g of homogenate, add 2 g of pepsin, adjust the pH value to 1.8, and perform enzymatic hydrolysis at 40°C for 6 hours; then add 2 g of trypsin to adjust the pH value to 7.5, and perform enzymatic hydrolysis at 40°C for 6 hours.

[0066] After enzymatic hydrolysis, the homogenate was filtered through a 300-mesh non-woven fabric to remove the residue, and then passed through a 10kDa filter membrane to remove the residue.

[0067] The filtrate obtained by ultrafiltration is nanofiltered 3 times through a nanofiltration machine (pressure 0.8MPa);

[0068] The resulting filtrate was filtered and freeze-dried.

[0069] The freeze-drying procedure was to freeze at -50°C for 2 hours, and then turn on the vacuum pump. When the vacuum degree is lower than 20Pa, raise the temperature of the frozen...

Embodiment 2

[0071] The preparation of embodiment 2 pig brain extract

[0072] Healthy pig brains were taken, cleaned and removed of connective tissue, then frozen and homogenized.

[0073] For every 1000 g of homogenate, add 1 g of pepsin, adjust the pH value to 1.6, and perform enzymatic hydrolysis at 42°C for 7 hours; then add 5 g of trypsin to adjust the pH value to 7.3, and perform enzymatic hydrolysis at 42°C for 5 hours.

[0074] After enzymatic hydrolysis, the homogenate was filtered through a 300-mesh non-woven fabric to remove the residue, and then passed through a 10kDa filter membrane to remove the residue.

[0075] The filtrate obtained by ultrafiltration is nanofiltered 3 times through a nanofiltration machine (pressure 0.8MPa);

[0076] The resulting filtrate was filtered and freeze-dried.

[0077] The freeze-drying procedure was to freeze at -35°C for 4 hours and then turn on the vacuum pump. When the vacuum degree is lower than 20Pa, raise the temperature of the frozen ...

Embodiment 3

[0079] The preparation of embodiment 3 pig brain extract

[0080] Healthy pig brains were taken, cleaned and removed of connective tissue, then frozen and homogenized.

[0081] For every 1000g of homogenate, add 5g of pepsin, adjust the pH value to 2.0, and enzymatically hydrolyze at 38°C for 5h; then add 1g of trypsin to adjust the pH value to 7.7, and enzymolyze at 38°C for 7h.

[0082] After enzymatic hydrolysis, the homogenate was filtered through a 300-mesh non-woven fabric to remove the residue, and then passed through a 10kDa filter membrane to remove the residue.

[0083] The filtrate obtained by ultrafiltration is nanofiltered 3 times through a nanofiltration machine (pressure 0.8MPa);

[0084] The resulting filtrate was filtered and freeze-dried.

[0085] The freeze-drying procedure was to freeze at -43°C for 3 hours and then turn on the vacuum pump. When the vacuum degree is lower than 20Pa, raise the temperature of the frozen product to -20°C and keep the temper...

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Abstract

The invention relates to the technical field of biological medicine, in particular to a pig brain extract, a composition containing the pig brain extract and application of the composition. The molecular weight of the pig brain extract is no more than 10 kDa and no less than 200 kDa, and the pig brain extract mainly comprises micro-molecule polypeptides or free amino acid, cephalin, lecithin, peptide nerve growth factors and the like. Experiments show that the composition obtained by compounding the pig brain extract, gamma-aminobutyric acid and linseed oil powder can achieve the effects of strengthening the brain and reinforcing intelligence.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a pig brain extract, a composition containing the pig brain extract and applications thereof. Background technique [0002] my country's first blue book on the development of aging undertakings - "China's Aging Development Report (2013)" was published in early 2013. According to the Blue Book, in 2012, the number of elderly people in my country reached 194 million, and the aging level reached 14.3%. China has a large elderly population base, the population aging process is fast, and the prevalence of chronic diseases in the elderly is high, and the prevalence rate has a tendency to double every 5 years. This disease has become a disease that cannot be ignored. This disease has become the successor to heart disease. , cancer, and the fourth leading cause of death after stroke. Patients with mild dementia may have changes in personality and behavior such as forgetfulness, ret...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/30A61P25/28A23L33/00A23L33/10A23L33/175A23L33/115
CPCA23V2002/00A61K31/197A61K35/30A61K36/55A61K2300/00A23V2200/30A23V2200/322A23V2250/038A23V2250/204
Inventor 张治国周天琼倪燕红傅诗丽黄嘉华高留根
Owner HANGZHOU HUAJIN PHARMA
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