A kind of preparation method and application of chitosan acetylsalicylate

A technology of chitosan acetylsalicylate and acetylsalicylic acid, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, digestive systems, etc., can solve problems such as affecting the dissolution and release of acetylsalicylic acid, and achieves The effect of preventing gastric ulcers, avoiding multiple doses, and having high solubility

Active Publication Date: 2018-08-28
YUHUAN MARINE BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is common practice to coat acetylsalicylic acid (aspirin) with a substance that does not dissolve in the stomach, but doing so can also interfere with the dissolution and release of acetylsalicylic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of chitosan acetylsalicylate A:

[0021] (1) Purification of chitosan: dissolve a specified amount of chitosan with a degree of deacetylation greater than 90% and a viscosity less than 20MPa.S in 3% acetic acid, and the mass ratio of chitosan to 3% acetic acid is: 1 : 25, stir to make it dissolve completely, filter with 120 mesh polyester filter cloth, get the viscous chitosan acetate liquid, then adjust the pH value of the liquid to 8.0 with 10% sodium hydroxide, leave standstill for 10 hours , so that chitosan is completely separated from the solution, and then filtered and squeezed to fully squeeze out the moisture in the feed liquid, repeatedly soaked, washed, and press-filtered with purified water until the pH of the washing liquid is 7.5, then dried, crushed, and filtered Sieve to obtain purified chitosan;

[0022] (2) Preparation of chitosan salicylate: the purified chitosan obtained in step (1) is dispersed in 75% ethanol solution with a solid-to-li...

Embodiment 2

[0025] Preparation of chitosan acetylsalicylate B:

[0026] (1) Purification of chitosan: dissolve a specified amount of chitosan with a degree of deacetylation greater than 90% and a viscosity less than 20MPa.S in 1% acetic acid. The mass ratio of chitosan to 1% acetic acid is: 1 :30, stir to make it dissolve completely, filter with 120 mesh polyester filter cloth, get the viscous chitosan acetate liquid, then adjust the pH value of the liquid to 7.7 with 3% sodium hydroxide, leave standstill for 8 hours , to completely precipitate chitosan from the solution, then filter and squeeze to fully squeeze out the moisture in the feed liquid, repeatedly soak, wash, and press filter with purified water until the pH of the washing liquid is 7.4, then dry, pulverize, and filter Sieve to obtain purified chitosan;

[0027] (2) Preparation of chitosan salicylate: the purified chitosan obtained in step (1) is dispersed in 85% ethanol solution with a solid-to-liquid ratio of 1:3, and acety...

Embodiment 3

[0030] Preparation of chitosan acetylsalicylate C:

[0031] (1) Purification of chitosan: dissolve a specified amount of chitosan with a degree of deacetylation greater than 90% and a viscosity less than 20MPa.S in 2% acetic acid. The mass ratio of chitosan to 2% acetic acid is: 1 : 35 stirring to make it dissolve completely, filter with 120 mesh polyester filter cloths, get viscous chitosan acetate liquid, then adjust the pH value of the liquid to 7.5 with 15% sodium hydroxide, leave standstill for 5 hours, Completely precipitate chitosan from the solution, then filter and squeeze to fully squeeze out the water in the feed liquid, repeatedly soak, wash, and press filter with purified water until the pH value of the washing liquid is 7.2, then dry, crush, and sieve , to obtain purified chitosan;

[0032] (2) Preparation of chitosan salicylate: the purified chitosan of step (1) is dispersed in 95% ethanol solution with a solid-to-liquid ratio of 1:10, and acetylsalicylic acid ...

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Abstract

The invention relates to a preparation method and an application of chitosan acetylsalicylate. The preparation method specifically comprises the following steps of purifying the chitosan, and preparing the chitosan acetylsalicylate. The prepared chitosan acetylsalicylate has the advantages that the gastric ulcer caused by acetylsalicylic acid can be prevented; the chitosan acetylsalicylate is slowly dissolved in the stomach, an acetylsalicylic acid slow-releasing type is provided for medicine-taking populations, the defect of multiple times of medicine taking is avoided, and the convenience is realized for patients.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method and application of chitosan acetylsalicylate. Background technique [0002] Chitosan acetylsalicylate is a unique compound composed of chitosan and acetylsalicylic acid (aspirin). Acetylsalicylic acid (aspirin) has two main applications: as a non-steroidal anti-inflammatory agent, which has analgesic and anti-inflammatory effects, and as an antiplatelet agent, which delays the formation of blood clots. These two properties (non-steroidal anti-inflammatory agent and anticoagulant action) of acetylsalicylic acid (aspirin) are clearly dose-dependent. The anti-inflammatory effects of acetylsalicylic acid (aspirin) become evident at doses up to one dose of 5 grains (311 mg) (a grain is the Anglo-American unit of weight). However, taking a large amount of acetylsalicylic acid (aspirin) can inhibit the synthesis of cycloprostaglandin. [0003] The fields of ap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61P1/04A61P7/02A61P29/00A61P25/06A61P9/10A61K31/722
CPCA61K31/722C08B37/003
Inventor 石勇闫福根林荣业杜予民林昌敏
Owner YUHUAN MARINE BIOCHEM
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