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A kind of antibacterial agent and preparation method thereof
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A technology of antibacterial agents and solvents, applied in botany equipment and methods, biocides, disinfectants, etc., can solve the problems of poor heat resistance, poor heat resistance and durability, and low sterilization rate, so as to improve the antibacterial effect and improve Effect of heat resistance and efficiency improvement
Active Publication Date: 2017-12-08
河北明大医疗器械有限公司
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Inorganic antibacterial agents have the advantages of high safety, good heat resistance, and good durability, but they have the disadvantage of antibacterial delay. Common inorganic antibacterial agents include silver nitrate, zincoxide, copperoxide, ammonium dihydrogen phosphate, lithiumcarbonate, etc. ; Organic antibacterial agents have high short-term antibacterial properties, but their heat resistance and durability are poor, and they are easy to hydrolyze. Thiazolone derivatives, etc.; natural antibacterial agents mainly come from the extraction of natural plants, such as chitin, mustard, castor oil, horseradish, etc., which are easy to use, but have limited antibacterial effects, poor heat resistance, low bactericidal rate, and cannot be broad-spectrum long-term Effective use and few
It can be seen that the above-mentioned single-type antibacterial agent is difficult to meet the needs of the existing market for antibacterial agents, so it is difficult to realize a real spectral antibacterial agent
Method used
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[0044] As a preferred embodiment of the present invention, the volume ratio of the 1,4-dioxane to N,N-dimethylformamide is (1-2):1.
[0047] As a preferred embodiment of the present invention, the product B is a compound of formula (II):
[0048]
[0049] Among them, in formula (II), R is benzyl or C 4 -C 16 Alkyl; X is Cl or Br; m is 20-120, n is 25-100.
[0050] Another object of the present invention is to provide the application of said antibacterial agent in the fields of plastics, coatings, fabrics, paper, rubber, resin, wood, building materials or water treatment, and firmly introduce antibacterial groups into substrates by chemical bonding Zhongyi provides a broad-spectrum, high-efficiency...
Embodiment approach 1
[0052] Embodiment 1, an antibacterial agent, the antibacterial agent is a compound of the structure described in formula (I):
[0053]
[0054] Wherein, in formula (I), R is benzyl or C 4 -C 16 Alkyl; R 1 Cl or Br; X is Cl or Br; m is 20-120, n is 25-100.
Embodiment approach 2
[0055] Embodiment 2, the method for preparing described antibacterial agent, comprises the following steps:
[0056] a. Add dimethylaminoethyl methacrylatealkyl or benzyl halide, maleic anhydride, and solvent into the reaction vessel, stir and feed nitrogen, raise the temperature to 35-60°C, add the initiator, and react 5-12h, then raise the temperature to 50-70°C, continue the reaction for 1-2h, cool, separate and purify to obtain product A, wherein the dimethylaminoethyl methacrylatealkyl or benzyl halide and maleic anhydride The molar ratio is (1-14): (6-19);
[0057] b. Dissolve the product A and aminopropyl POSS in step a in toluene, react at 80-95°C for 20-30h, separate and purify, and obtain product B, wherein the molar ratio of aminopropyl POSS to product A is for (1.0-1.08): 1;
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Abstract
The invention relates to an antibacterial agent and a preparation method thereof. The method comprises the following steps of a, adding methacrylatedimethylaminoethyl esteralkyl or benzyl halide, maleic anhydride and solvents into a reaction vessel; performing stirring; introducing nitrogen; raising the temperature to 35 to 60 DEG C; adding initiators; performing reaction for 5 to 12h; then, raising the temperature to 50 to 70 DEG C; continuously performing reaction for 1 to 2h; performing cooling, separation and purification to obtain a product A, wherein the mol ratio of the methacrylatedimethylaminoethyl esteralkyl or benzyl halide to maleic anhydride is (1 to 14) to (6 to 19); b, dissolving the product A in the step a and aminopropyl POSS into methylbenzene; performing separation purification after the reaction for 20 to 30h at 80 to 95 DEG C to obtain a product B, wherein the mol ratio of the aminopropyl POSS and the product A is (1.0 to 1.08) to 1; c, putting the product B in the step b into sodiumhypochlorite or sodiumhypobromite; performing still reaction for 1 to 2h at the room temperature; performing filtration and drying to obtain an antibacterial agent. The antibacterial agent has the advantages of long effect, high efficiency, heat resistance, wide spectrum, no drug resistance and biological safety.
Description
technical field [0001] The invention belongs to the technical field of antibacterial agents, more specifically, the invention relates to an antibacterial agent with long-acting, high efficiency, heat resistance, broad spectrum, no drug resistance, and biological safety and a preparation method thereof. Background technique [0002] With the development of society and the continuous improvement of people's living standards, people have put forward higher requirements for the environmental quality and hygiene level they depend on for survival. At the same time, various pathogenic microorganisms are widely distributed in nature, and grow, reproduce, and even mutate under certain conditions, which not only cause corrosion and decomposition of materials, but also threaten human health. Thereby, the antibacterial product that can guarantee health to some extent is more and more subject to people's favor. [0003] Antibacterial refers to the function of inhibiting and killing bact...
Claims
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Application Information
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