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Novel application of condonpsis lanceolata extract in preparation of medicine and healthcare products for preventing renal injuries

A technology of Codonopsis verticillum and extract, which is applied in the direction of drug combination, medical preparations containing active ingredients, antipyretics, etc., to achieve remarkable curative effect, convenient operation, and good industrialization prospects

Inactive Publication Date: 2016-11-09
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] So far, there has been no report about the protective effect of the drug on acute kidney injury caused by cisplatin. The present invention proposes and proves the protective effect of the extract on acute kidney injury

Method used

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  • Novel application of condonpsis lanceolata extract in preparation of medicine and healthcare products for preventing renal injuries
  • Novel application of condonpsis lanceolata extract in preparation of medicine and healthcare products for preventing renal injuries
  • Novel application of condonpsis lanceolata extract in preparation of medicine and healthcare products for preventing renal injuries

Examples

Experimental program
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Effect test

experiment example

[0013] Experimental example. Protective effect and mechanism of steamed Codonopsis verticillum on cisplatin-induced kidney injury in mice

[0014] 1 Materials and methods

[0015] 1.1 Experimental animals

[0016] SPF-grade ICR mice, male, weighing 20-22 g, were purchased from Changchun Yisi Experimental Animal Technology Co., Ltd., certificate number: SCXK (Ji) 2011-0004. Adaptive feeding in the environment of 12h day and night cycle, free to drink water and eat, test after 1 week.

[0017] 1.2 Reagents and Drugs

[0018] Fresh Codonopsis verticillum, purchased from Baishan City, Jilin Province, identified by Associate Professor Li Wei of Jilin Agricultural University; cisplatin, Shanghai Siyu Chemical Technology Co., Ltd., purity >99.0%; hematoxylin-eosin staining solution (H&E), creatinine (CRE ), urea nitrogen (BUN), malondialdehyde (MDA) and other kits were purchased from Nanjing Jiancheng Institute of Bioengineering; inflammatory factors TNF-α and IL-1β were purchased...

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Abstract

The invention discloses application of condonpsis lanceolata extract in preparation of medicine for preventing cisplatin induced acute renal injuries and belongs to the field of medicine product research and development. The animal experiment research shows that compared with a model set, the condonpsis lanceolata extract can effectively reduce the content of creatinine (CRE), urea nitrogen (BUN), inflammatory factors (TNF-alpha) and interleukin 1beta (IL-1beta) in serum and malonaldehyde (MDA) in nephridial tissue; in addition, histopathology shows that the condonpsis lanceolata extract can reduce lesions of the nephridial tissue and reduce apoptosis of nephridial tissue cells; immunohistochemistry shows that the condonpsis lanceolata extract can effectively reduce expression of Bax and increase expression of Bcl-2. Thus, the condonpsis lanceolata extract and effective ingredients containing the extract can be prepared into the medicine or healthcare products for preventing acute renal injuries, the forms of the medicine or the healthcare products can be existing any dosage forms such as tablets, capsules, pills, soft capsules, granules and patches.

Description

technical field [0001] The invention discloses steamed Codonopsis pilosula (Steamed Codonopsis lanceolata ) in the new application of preparing drugs for preventing acute kidney injury, which belongs to the medical technology field of new biological activity of traditional Chinese medicine. Background technique [0002] Cisplatin (Cisplatin) has a good curative effect on a variety of tumors, and is one of the most effective and common antineoplastic drugs in clinical use. At present, cisplatin is widely used in clinic as an important chemotherapeutic drug. As a broad-spectrum anticancer drug, cisplatin has a curative effect proportional to the dosage, but at the same time, with the increase of the dosage, the toxicity of the drug also increases, which is likely to cause a variety of adverse reactions, such as gastrointestinal reactions, bone marrow suppression, ear Toxicity, etc., especially its high accumulation, high excretion, and high metabolism in the kidney. Among t...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61P13/12A61P29/00A23L33/00A61K9/48A61K9/20
CPCA61K36/344A61K9/1617A61K9/2013A61K9/4866A61K2236/15A61K2236/17
Inventor 李伟赵立春孙印石
Owner JILIN AGRICULTURAL UNIV
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