Method for preparing metoprolol salt
A technology of mixed solvent and acetone, which is applied in the field of metoprolol salt preparation, can solve the problems of complex pH value detection process, difficult removal of impurities, long reaction time, etc., and achieve easy recycling, reduction of three wastes discharge, and simple treatment Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0029] First the mixed system of tartaric acid (0.5mol, 75g), acetone (890g) and water (61.4g) was warmed up and refluxed until tartaric acid was completely dissolved, then under reflux, formula (II) metoprolol (1mol, 267g) Add the mixed solution of acetone (311.5g) dropwise to the solution, after the dropwise addition, keep it warm at 50-65°C for 0.5 hours, cool to 0-5°C, stir and crystallize for 1 hour, after the crystallization , suction filtration, drying to obtain formula (I) metoprolol salt 307.22g, productive rate 89.7%.
Embodiment 2
[0031] First the mixed system of tartaric acid (0.5mol, 75g), acetone (890g) and water (61.4g) was warmed up and refluxed until tartaric acid was completely dissolved, then under reflux, formula (II) metoprolol (1mol, 267g) Add the mixed solution of acetone (311.5g) dropwise to the solution, after the dropwise addition, keep it warm at 50-65°C for 1 hour, cool to 0-5°C, stir and crystallize for 1 hour, after the crystallization , suction filtration, drying to obtain formula (I) metoprolol salt 307.57g, productive rate 89.8%.
Embodiment 3
[0033] First the mixed system of tartaric acid (0.5mol, 75g), acetone (890g) and water (61.4g) was warmed up and refluxed until tartaric acid was completely dissolved, then under reflux, formula (II) metoprolol (1mol, 267g) Add the mixed solution of acetone (311.5g) dropwise to the solution, after the dropwise addition, keep it warm at 50-65°C for 0.5 hours, cool to 0-5°C, stir and crystallize for 2 hours, after the crystallization , suction filtration, drying to obtain formula (I) metoprolol salt 320.24g, productive rate 93.5%.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com