Preparation method for polyvinyl alcohol sponge microneedle

A technology of polyvinyl alcohol sponge and polyvinyl alcohol solution, which is applied in the field of microneedles, can solve the problems of poor hydrogel strength, breakage, and easy breakage, and achieve the effect of enhanced strength and strong strength

Active Publication Date: 2016-11-16
PUTIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. The hydrogel microneedles produced by the above technology adopt physical cross-linking, which usually leads to low cross-linking degree and weak hydrogel strength, and the hydrogel microneedles made do not have enough strength to penetrate the skin
Moreover, the re-formed hydrogel microneedles have poor strength and are easy to break, which will cause unnecessary side effects when entering the human body.
[0004] 2. The hydrogel microneedles produced by the above technology adopt chemical cross-linking. Although the degree of cross-linking can be increased and the strength of the hydrogel can be improved to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example one

[0028] A preparation method of polyvinyl alcohol sponge microneedles includes the following steps:

[0029] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a mass percentage of 14%, for use;

[0030] The mass percent concentration of the polyvinyl alcohol solution is 14%, that is, the mass of polyvinyl alcohol contained in every 100 g of the polyvinyl alcohol solution (solvent plus solute) is 14 grams.

[0031] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of foaming agent added accounts for 5% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring evenly; first add formaldehyde solution (or formalin), the amount of formaldehyde solution added is 15% of the total mass of the mixed solution, ...

Example Embodiment

[0039] Example two

[0040] A preparation method of polyvinyl alcohol sponge microneedles includes the following steps:

[0041] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a mass percentage of 8%, for use;

[0042] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of foaming agent added accounts for 1% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane, and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring evenly; first add formaldehyde solution (or formalin), the amount of formaldehyde solution added is 1% of the total mass of the mixed solution, and then add concentrated sulfuric acid Solution, the dosage is 5% of the total mass of the mixed solution, stir evenly to obtain the mixed solution;

[0043] S3. Inject the above-mentioned mixed solution into the m...

Example Embodiment

[0046] Example three

[0047] A method for preparing polyvinyl alcohol sponge microneedles includes the following steps:

[0048] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a concentration of 20% by weight, for use;

[0049] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of the foaming agent added accounts for 10% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane, and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring uniformly; first add the formaldehyde solution (or formalin), the amount of formaldehyde solution added is 20% of the total mass of the mixed solution, and then add concentrated sulfuric acid Solution, the amount is 18% of the total mass of the mixed solution, stir evenly to obtain the mixed solution;

[0050] S3. Inject the above-mentioned m...

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PUM

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Abstract

The invention relates to a preparation method for a polyvinyl alcohol sponge microneedle. The method includes the steps that a polyvinyl alcohol solution is prepared, a foaming agent is added into the polyvinyl alcohol solution and evenly stirred, then a formaldehyde solution and a concentrated sulfuric acid solution are sequentially added, and a mixed solution is prepared after even stirring; and the mixed solution is injected into a microneedle mold and solidified, and the polyvinyl alcohol sponge microneedle is obtained after demolding and cleaning. Formaldehyde is used as a cross-linking agent, the obtained polyvinyl alcohol sponge microneedle is high in strength and can be easily pierced into skin, washed with clean water repeatedly and used for continuous and repeated dosing, and the safety and practicability of the polyvinyl alcohol sponge microneedle are greatly improved.

Description

technical field [0001] The invention relates to the technical field of microneedles, in particular to a preparation method of polyvinyl alcohol sponge microneedles. Background technique [0002] In recent years, the popularity of cosmetic microneedling has made more and more people understand microneedle technology. In the prior art, there has been a hydrogel microneedle, which is prepared by preparing an aqueous polymer solution, injecting it into a microneedle mold, and gelling the aqueous polymer solution by physical crosslinking or chemical crosslinking. After drying, the hydrogel microneedles are made by releasing the mold. The use method of the microneedle: the hydrogel microneedle penetrates the skin, absorbs the tissue fluid in the skin, makes the dry microneedle become a hydrogel state again, and penetrates the hydrogel needle body in the skin and the water of the microneedle The gel dorsal scale becomes the drug delivery channel, and the drug is placed on the mic...

Claims

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Application Information

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IPC IPC(8): B29C44/02B29K29/00B29L31/00
CPCB29C44/02B29K2029/04B29L2031/7544
Inventor 陈健敏阮志鹏杨周琰
Owner PUTIAN UNIV
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