Preparation method for polyvinyl alcohol sponge microneedle

A technology of polyvinyl alcohol sponge and polyvinyl alcohol solution, which is applied in the field of microneedles, can solve the problems of poor hydrogel strength, breakage, and easy breakage, and achieve the effect of enhanced strength and strong strength

Active Publication Date: 2016-11-16

PUTIAN UNIV

5 Cites 1 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0003] 1. The hydrogel microneedles produced by the above technology adopt physical cross-linking, which usually leads to low cross-linking degree and weak hydrogel strength, and the hydrogel microneedles made do not have enough strength to penetrate the skin

Moreover, the re-formed hydrogel microneedles have poor strength and are easy to break, which will cause unnecessary side effects when entering the human body.

[0004] 2. The hydrogel microneedles produced by the above technology adopt chemical cross-linking. Although the degree of cross-linking can be increased and the strength of the hydrogel can be improved to ...

Method used

The present embodiment uses formaldehyde as cross-linking agent, makes polyvinyl alcohol sponge microneedle, and the intensity of the sponge microneedle of making is higher, helps to pierce skin. The strength of sponge microneedles can withstand washing with water to remove residual reagents, which is safer than hydrogel microneedles. The strength of the sponge microneedle enables it ...

Abstract

The invention relates to a preparation method for a polyvinyl alcohol sponge microneedle. The method includes the steps that a polyvinyl alcohol solution is prepared, a foaming agent is added into the polyvinyl alcohol solution and evenly stirred, then a formaldehyde solution and a concentrated sulfuric acid solution are sequentially added, and a mixed solution is prepared after even stirring; and the mixed solution is injected into a microneedle mold and solidified, and the polyvinyl alcohol sponge microneedle is obtained after demolding and cleaning. Formaldehyde is used as a cross-linking agent, the obtained polyvinyl alcohol sponge microneedle is high in strength and can be easily pierced into skin, washed with clean water repeatedly and used for continuous and repeated dosing, and the safety and practicability of the polyvinyl alcohol sponge microneedle are greatly improved.

Application Domain

Domestic articles

Technology Topic

Repeated dosingPolyvinyl alcohol sponge +8

Examples

Experimental program(3)

Example Embodiment

[0027] Example one

[0028] A preparation method of polyvinyl alcohol sponge microneedles includes the following steps:

[0029] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a mass percentage of 14%, for use;

[0030] The mass percent concentration of the polyvinyl alcohol solution is 14%, that is, the mass of polyvinyl alcohol contained in every 100 g of the polyvinyl alcohol solution (solvent plus solute) is 14 grams.

[0031] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of foaming agent added accounts for 5% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring evenly; first add formaldehyde solution (or formalin), the amount of formaldehyde solution added is 15% of the total mass of the mixed solution, and then add concentrated sulfuric acid Solution, the dosage is 14% of the total mass of the mixed solution, stir evenly to obtain the mixed solution;

[0032] The advantage of n-pentane physical foaming agent is: the formation of foam pores through the change of the physical form of n-pentane, that is, the formation of foam pores through the expansion of compressed gas, the volatilization of liquids or the dissolution of solids, and strengthen the strength of microneedles.

[0033] Formaldehyde is used as a cross-linking agent to make polyvinyl alcohol sponge microneedles, which further enhances the strength of the microneedles and facilitates penetration into the skin.

[0034] S3. Inject the above-mentioned mixed solution into the microneedle mold by the vacuum method or negative pressure method, make the mixed solution fill the micro-holes of the microneedle mold, after filling, place the microneedle mold in an oven at 50 ℃ for curing for 4 hours The cured microneedle mold is stripped to obtain semi-finished microneedles;

[0035] The specific steps of the vacuum method are as follows, because the holes on the microneedle mold are very small, and the solution is difficult to enter the micropores because there is air in the micropores directly. Therefore, it is necessary to place the microneedle mold filled with the solution in a vacuum environment to release the air in the micropores, and then the solution enters the micropores of the microneedle mold. The specific steps of the negative pressure method are as follows. The microneedle mold filled with the solution is placed in an environment with a pressure higher than 3 times the atmospheric pressure. Because the air pressure in the micropore is different from the external pressure, the external pressure will force the solution into the microneedle mold. hole.

[0036] S4. Wash the semi-finished microneedles with clean water to remove residual reagents, and after drying, obtain polyvinyl alcohol sponge microneedles.

[0037] The polyvinyl alcohol sponge microneedles made in this embodiment have sufficient strength. Therefore, they can be cleaned sufficiently to remove unreacted formaldehyde and concentrated sulfuric acid and other residual reagents, making them safer without affecting their strength and form.

[0038] After the polyvinyl alcohol sponge microneedles made in this embodiment penetrate the skin, they can quickly absorb the moisture in the tissue fluid and have stronger strength than hydrogel. Therefore, the formed drug channel can be continuously and repeatedly Administer without breaking.

Example Embodiment

[0039] Example two

[0040] A preparation method of polyvinyl alcohol sponge microneedles includes the following steps:

[0041] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a mass percentage of 8%, for use;

[0042] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of foaming agent added accounts for 1% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane, and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring evenly; first add formaldehyde solution (or formalin), the amount of formaldehyde solution added is 1% of the total mass of the mixed solution, and then add concentrated sulfuric acid Solution, the dosage is 5% of the total mass of the mixed solution, stir evenly to obtain the mixed solution;

[0043] S3. Inject the above-mentioned mixed solution into the microneedle mold by the vacuum method or the negative pressure method, make the mixed solution fill the micro-holes of the microneedle mold, and then place the microneedle mold in an oven at 30°C for 8 hours to cure. The cured microneedle mold is stripped to obtain semi-finished microneedles;

[0044] S4. Wash the semi-finished microneedles with clean water to remove residual reagents, and after drying, obtain polyvinyl alcohol sponge microneedles.

[0045] After the polyvinyl alcohol sponge microneedles made in this embodiment penetrate the skin, they can quickly absorb the moisture in the tissue fluid and have stronger strength than hydrogels. Therefore, the strength of the microneedles is enhanced and the microneedles can be easily adjusted. After cleaning, the formed drug channel can be administered continuously and repeatedly without damage.

Example Embodiment

[0046] Example three

[0047] A method for preparing polyvinyl alcohol sponge microneedles includes the following steps:

[0048] S1. Weigh the required white solid polyvinyl alcohol, heat and dissolve it with distilled water to prepare a polyvinyl alcohol solution with a concentration of 20% by weight, for use;

[0049] S2. Add a foaming agent to the above polyvinyl alcohol solution. The amount of the foaming agent added accounts for 10% of the total mass of the mixed solution. Specifically, the foaming agent is any one of sodium bicarbonate, pentane, and n-hexane , The foaming agent used in this embodiment is sodium bicarbonate, after stirring uniformly; first add the formaldehyde solution (or formalin), the amount of formaldehyde solution added is 20% of the total mass of the mixed solution, and then add concentrated sulfuric acid Solution, the amount is 18% of the total mass of the mixed solution, stir evenly to obtain the mixed solution;

[0050] S3. Inject the above-mentioned mixed solution into the microneedle mold by vacuum or negative pressure method, make the mixed solution fill the micro-holes of the microneedle mold, after filling, place the microneedle mold in an oven at 70°C for 1 hour to cure, right The cured microneedle mold is stripped to obtain semi-finished microneedles;

[0051] S4. Wash the semi-finished microneedles with clean water to remove residual reagents, and after drying, obtain polyvinyl alcohol sponge microneedles.

[0052] In this embodiment, formaldehyde is used as a cross-linking agent to make polyvinyl alcohol sponge microneedles. The made sponge microneedles have higher strength and are beneficial to piercing the skin. The strength of the sponge microneedles can withstand washing with water to remove residual reagents, and is safer than hydrogel microneedles. The strength of the sponge microneedle allows it to be administered continuously for many times, while the prior art hydrogel microneedle is easily damaged due to poor strength, and the damaged material enters the human body and causes unnecessary side effects.

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High strength steel pipe for low-temperature usage having excellent buckling resistance and toughness of welded heat affected zone and method for producing the same

ActiveUS20120018028A1high strength

Owner:JFE STEEL CORP

Classification and recommendation of technical efficacy words

high strength
Strong

Preparation method for polyvinyl alcohol sponge microneedle

A technology of polyvinyl alcohol sponge and polyvinyl alcohol solution, which is applied in the field of microneedles, can solve the problems of poor hydrogel strength, breakage, and easy breakage, and achieve the effect of enhanced strength and strong strength

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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