Preparation method for polyvinyl alcohol sponge microneedle

Abstract

The invention relates to a preparation method for a polyvinyl alcohol sponge microneedle. The method includes the steps that a polyvinyl alcohol solution is prepared, a foaming agent is added into the polyvinyl alcohol solution and evenly stirred, then a formaldehyde solution and a concentrated sulfuric acid solution are sequentially added, and a mixed solution is prepared after even stirring; and the mixed solution is injected into a microneedle mold and solidified, and the polyvinyl alcohol sponge microneedle is obtained after demolding and cleaning. Formaldehyde is used as a cross-linking agent, the obtained polyvinyl alcohol sponge microneedle is high in strength and can be easily pierced into skin, washed with clean water repeatedly and used for continuous and repeated dosing, and the safety and practicability of the polyvinyl alcohol sponge microneedle are greatly improved.

Description

technical field [0001] The invention relates to the technical field of microneedles, in particular to a preparation method of polyvinyl alcohol sponge microneedles. Background technique [0002] In recent years, the popularity of cosmetic microneedling has made more and more people understand microneedle technology. In the prior art, there has been a hydrogel microneedle, which is prepared by preparing an aqueous polymer solution, injecting it into a microneedle mold, and gelling the aqueous polymer solution by physical crosslinking or chemical crosslinking. After drying, the hydrogel microneedles are made by releasing the mold. The use method of the microneedle: the hydrogel microneedle penetrates the skin, absorbs the tissue fluid in the skin, makes the dry microneedle become a hydrogel state again, and penetrates the hydrogel needle body in the skin and the water of the microneedle The gel dorsal scale becomes the drug delivery channel, and the drug is placed on the mic...

AI Technical Summary

Problems solved by technology

[0003] 1. The hydrogel microneedles produced by the above technology adopt physical cross-linking, which usually leads to low cross-linking degree and weak hydrogel strength, and the hydrogel microneedles made do not have enough strength to penetrate the skin

Moreover, the re-formed hydrogel microneedles have poor strength and are easy to break, which will cause unnecessary side effects when entering the human body.

[0004] 2. The hydrogel microneedles produced by the above technology adopt chemical cross-linking. Although the degree of cross-linking can be increased and the strength of the hydrogel can be improved to a certain extent, the chemical cross-linking agent is easy to remain in the hydrogel. It can be removed by washing with a large amount of water, but the strength of the hydrogel is poor, and the cleaning process will easily lead to breakage or damage of the hydrogel microneedle, which will affect the effective penetration of the microneedle

[0005] 3. Due to the poor strength of the hydrogel, the hydrogel microneedles made may not have sufficient mechanical strength to penetrate the skin, and the strength of the hydrogel formed by piercing the skin is poor, and continuous or multiple administration cannot be achieved