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Compound ketoconazole liniment and preparation method thereof

A technology of compound ketoconazole coating film and ketoconazole, which is applied in the direction of anti-inflammatory agent, antifungal agent, pharmaceutical formula, etc., can solve the problems such as the preparation of compound ketoconazole coating agent that has not been seen yet, and achieve good therapeutic effect , Easy to use and safe effect

Inactive Publication Date: 2016-11-23
成都薇诺娜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

, but have not yet seen the preparation of the compound ketoconazole coating agent

Method used

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Experimental program
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Effect test

Embodiment

[0020] The compound ketoconazole coating agent of the present embodiment is expressed in parts by weight. The ketoconazole is 0.5g, tartaric acid is 12g, peppermint oil is 10ml, polyvinyl alcohol is 70g, ethylene glycol 100g, paraben 1.8g of ester, 400ml of ethanol solution, enough purified water.

[0021] In this embodiment, ketoconazole and tartaric acid are mainly used as main agents, polyvinyl alcohol is used as a film-forming material, and ethylene glycol and peppermint oil are used as penetration enhancers.

[0022] Ketoconazole is an antifungal drug that has inhibitory effects on dermatophytes such as Trichophyton, Epidermophyton, Microsporum and yeasts such as Candida.

[0023] Its specific preparation method comprises the following steps:

[0024] (1) Add 100g of ethylene glycol to 300ml of purified water, stir to mix evenly, and obtain a mixed solution;

[0025] (2) Take 70g of polyvinyl alcohol and completely soak it in the mixed liquid mentioned in step (1), heat...

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PUM

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Abstract

The invention discloses a compound ketoconazole liniment. The liniment is prepared from the following components by weight: 0.1-1.6g of ketoconazole, 10-25g of tartaric acid, 5-15ml of peppermint oil, 20-80g of polyvinyl alcohol, 50-150g of ethylene glycol, 1.2-3.6g of methylparaben, 200-600ml of an alcohol solution and an enough amount of purified water. The liniment has bacteriostatic and antibacterial effects on fungi, saccharomycetes, dimorphic fungi and eumycetes after being applied to skin to form a film, is not percutaneously absorbed due to external application in local parts, is convenient and safe to use, and has an excellent treatment effect.

Description

technical field [0001] The invention relates to the technical field of film coating agent preparation, in particular to a compound ketoconazole film coating agent and a preparation method thereof. Background technique [0002] Ketoconazole is off-white crystalline powder; odorless and tasteless. This product is soluble in chloroform, soluble in methanol, slightly soluble in ethanol, almost insoluble in water. Melting point The melting point of this product is 147-151°C. Specific rotation Take this product, accurately weigh it, add methanol to make a solution containing 40mg per 1ml, measure it according to the law, and calculate according to the dry product, the specific rotation should be -1° to +1°. This product is a pink suspension. The product dissolves in gastric acid and is easily absorbed. When the acidity of gastric acid decreases, the absorption can be reduced. After absorption, it is widely distributed in the body, and can reach inflammatory joint fluid, saliva...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K9/70A61K47/32A61K47/10A61K47/44A61P31/10A61P37/08A61P29/00A61K31/194
CPCA61K31/496A61K9/7015A61K31/194A61K47/10A61K47/32A61K47/44A61K2300/00
Inventor 车洪泽
Owner 成都薇诺娜生物科技有限公司
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