Unlock instant, AI-driven research and patent intelligence for your innovation.

Rupikang solid dispersion preparation and preparation method thereof

A technology of solid dispersion and Rupikang, which is applied in the field of medicine, can solve the problems of clinical application range and large-scale production limitations, low dissolution rate and bioavailability, insufficient extraction of active ingredients, etc., to achieve safe and effective treatment solutions, drugs The effect of high bioavailability and sufficient extraction of active ingredients

Active Publication Date: 2016-11-23
GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the simple extraction process of Rupikang preparations currently on the market, the extraction of active ingredients is insufficient, the extracted ointment has a high viscosity, slow dissolution rate, low dissolution rate and low bioavailability, which makes the drug onset slow and difficult to obtain. The defects such as low efficacy and large dosage limit the scope of clinical application and large-scale production of the drug.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rupikang solid dispersion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the preparation of Rupikang solid dispersion

[0062] (1) The Chinese medicine ingredients of the said amount: 500g of Prunella vulgaris, 500g of orange leaves, 200g of safflower, 200g of turmeric, 200g of saponins, 200g of Rhizoma Cyperi, and 200g of earthworms are crushed, and soaked in 8 times the amount of water for 5 hours , extracted by steam distillation for 4 hours, collected and extracted volatile oil, and set aside;

[0063] (2) Filter the medicinal dregs in step 1, concentrate the medicinal liquid into a thick ointment, set aside, add 6 times the amount of 80% ethanol to the medicinal dregs and reflux for extraction for 3 hours, filter, discard the medicinal residues, recover the ethanol from the medicinal liquid to obtain a thick ointment , mix the thick ointment obtained by two extractions, add 5 times the amount of 55% ethanol water to dilute and stir the ointment, and after centrifugation, the supernatant passes through a filter membrane wit...

Embodiment 2

[0066] Embodiment 2: the preparation of Rupikang solid dispersion

[0067] (1) The traditional Chinese medicine ingredients of the stated amount: 350g of Prunella vulgaris, 350g of orange leaves, 150g of safflower, 150g of turmeric, 150g of saponins, 150g of Rhizoma Cyperi, 150g of earthworm, crushed, and soaked in 8 times the amount of water for 5 hours , extracted by steam distillation for 4 hours, collected and extracted volatile oil, and set aside;

[0068] (2) Filter the medicinal dregs in step 1, concentrate the medicinal liquid into a thick ointment, set aside, add 6 times the amount of 80% ethanol to the medicinal dregs and reflux for extraction for 3 hours, filter, discard the medicinal residues, recover the ethanol from the medicinal liquid to obtain a thick ointment , mix the thick ointment obtained by two extractions, add 4 times the amount of 55% ethanol water to dilute and stir the ointment, and after centrifugation, the supernatant passes through a filter membra...

Embodiment 3

[0076] Embodiment 3: the preparation of Rupikang solid dispersion

[0077] (1) The Chinese medicinal ingredients of the stated amount: 700g of Prunella vulgaris, 700g of orange leaves, 300g of safflower, 250g of turmeric, 350g of saponins, 300g of Cyperus cyperi, and 300g of earthworm, are crushed, and soaked in 8 times the amount of water for 5 hours , extracted by steam distillation for 4 hours, collected and extracted volatile oil, and set aside;

[0078] (2) Filter the medicinal dregs in step 1, concentrate the medicinal liquid into a thick ointment, set aside, add 10 times the amount of 80% ethanol to the medicinal dregs and reflux for extraction again for 3 hours, filter, discard the medicinal residues, recover the ethanol from the medicinal liquid to obtain a thick ointment , mix the thick ointment obtained by two extractions, add 6 times the amount of 55% ethanol water to dilute and stir the ointment, and after centrifugation, the supernatant passes through a filter me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a Rupikang solid dispersion preparation. Prescription amounts of common selfheal fruit-spike, tangerine leaves, safflower, turmeric root-tubers, Chinese honeylocust spine, nutgrass galingale rhizomes and earthworms are firstly subjected to water vapor reflux for extraction of an volatile oil medical component, a liposome is prepared, a medicine liquid is filtered and concentrated to form thick paste, dregs are subjected to reflux extraction once again with ethanol, ointments obtained through two times of extraction are mixed, impurities such as starch, tannins, resin and the like in a extract are removed through 55% ethanol precipitation, and then a solid dispersion is prepared from an extracted ointment and a carrier material, namely, polyvinylpyrrolidone. The method of the prepared Rupikang preparation is simple, extraction of active ingredients are fuller, the preparation takes effect quickly, the medicine is high in bioavailability, the efficacy time is long, the treatment effect is more significant, and a safer and more effective treatment scheme is provided for clinic.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and in particular relates to a Rupikang solid dispersion preparation and a preparation method thereof. technical background: [0002] Breast hyperplasia, also known as breast lobular hyperplasia, breast cystic chronic fibrous hyperplasia and other diseases, with breast lumps and pain as the two main symptoms, belongs to breast structural dysplasia. Mainly include simple hyperplasia of the mammary glands and cystic hyperplasia of the mammary glands, which are common and frequently-occurring diseases of young and middle-aged women. The age of onset is mainly concentrated in 25-50 years old, accounting for more than 75% of all breast diseases, ranking first in breast diseases. And the incidence rate is still on the rise in recent years. The pathogenesis and law of mammary gland hyperplasia are still unclear. Most scholars believe that the occurrence of mammary gland hyperplasia is due to ovarian...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/14A61K9/48A61P15/14A61K35/62
Inventor 郎洪平韦玉栋
Owner GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY