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Preparation method and application for SiO2/artemisinin antibacterial nanoparticles

A technology of antibacterial nanoparticles and artemisinin, which can be used in applications, preservation of meat/fish with chemicals, food science, etc., and can solve problems such as antibacterial activity discounts

Active Publication Date: 2016-12-07
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Artemisia annua, also known as Artemisia annua L., is a plant of the genus Artemisia in the Asteraceae chamomile family; artemisinin is a sesquivalent peroxide group extracted by Chinese researchers in 1972 from the stems and leaves of the plant Artemisia annua L. Terpene lactone drug is an active ingredient that can treat malaria; artemisinin has various pharmacological effects such as antimalarial, immune regulation, antitumor and antibacterial; but because artemisinin is water-insoluble, it will make its antibacterial activity In practical application, this research focuses on solving the problem of water solubility of artemisinin, improving its water dispersibility, thereby improving its antibacterial activity and increasing its bioavailability

Method used

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  • Preparation method and application for SiO2/artemisinin antibacterial nanoparticles
  • Preparation method and application for SiO2/artemisinin antibacterial nanoparticles
  • Preparation method and application for SiO2/artemisinin antibacterial nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 SiO 2 / Solubility of Artemisinin Antibacterial Nanoparticles

[0027] 1 Experimental materials

[0028]

[0029] 2 Experimental methods

[0030] ①Add 40.0mL of absolute ethanol, 10.0mL of deionized water and 2.0mL of ammonia water into the reaction flask, heat and stir on a heating type magnetic stirrer for 20min (60°C, 300rmp), then add 2.0mL of TEOS dropwise (guaranteed at All the drops were completed within 2 minutes), and 50 mg of artemisinin crystals were added immediately after the drops were completed, the temperature was maintained at 60°C, and stirring was continued at 300 rpm for 60 minutes.

[0031] ②Put the reaction bottle in an oven at 60°C for 48 hours, dry it in vacuum to evaporate the solvent; collect the prepared powder, grind it, wash it, dry it, grind it, and collect it.

[0032] ③Finally, the plasma is used to assist the treatment, and the treatment conditions are: power 800W, time 2min, SiO can be made 2 / Artemisinin Antibacterial...

Embodiment 2

[0040] Example 2 SiO 2 Determination of antibacterial performance of artemisinin antibacterial nanoparticles

[0041] 1 Experimental materials

[0042] SiO 2 / Artemisinin Antibacterial Nanoparticles - Plasma, SiO 2 / Artemisinin antibacterial nanoparticles, artemisinin crystals Strains: Escherichia coli, Staphylococcus aureus

[0043] 2 Experimental methods

[0044] The plate colony counting method was used to determine SiO with Escherichia coli and Staphylococcus aureus as model strains. 2 / Antibacterial properties of artemisinin antimicrobial nanoparticles.

[0045] Escherichia coli and Staphylococcus aureus were inoculated into the liquid medium, placed in an air shaker and cultured for 24-48 hours under the conditions of 37°C and 150rpm, respectively, to obtain a bacterial suspension in the logarithmic growth phase. Take an appropriate amount of Escherichia coli and Staphylococcus aureus that are saturated in the logarithmic phase of growth and add them to a test t...

Embodiment 3

[0049] Example 3 SiO 2 / Practical application of artemisinin antibacterial nanoparticles in beef

[0050] 1 Experimental materials

[0051] SiO 2 / Artemisinin Antibacterial Nanoparticles - Plasma, SiO 2 / Artemisinin antibacterial nanoparticles, artemisinin crystals Strains: Escherichia coli, Staphylococcus aureus Beef (cut into 25×20×5mm size)

[0052] 2 Experimental methods

[0053] The plate colony counting method was used to determine SiO with Escherichia coli and Staphylococcus aureus as model strains. 2 / Antibacterial properties of artemisinin antimicrobial nanoparticles.

[0054] Escherichia coli and Staphylococcus aureus were inoculated into the liquid medium, placed in an air shaker and cultured for 24-48 hours under the conditions of 37°C and 150rpm, respectively, to obtain a bacterial suspension in the logarithmic growth phase. Take an appropriate amount of Escherichia coli and Staphylococcus aureus, which are saturated in the logarithmic phase of growth, an...

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Abstract

The invention belongs to the fields of antibacterial agents and food additives, and specifically relates to a preparation method and application for SiO2 / artemisinin antibacterial nanoparticles. According to the invention, antibacterial nanoparticles are prepared by using nanometer SiO2 to adsorb artemisinin; meanwhile, plasma is combined to assist treatment, so the solubility of artemisinin in water can be improved, and a certain slow-release effect is obtained; thus, the bioavailability of artemisinin is improved, and the purposes of highly-efficient utilization and long-acting antisepsis are achieved.

Description

technical field [0001] The invention belongs to the field of antibacterial agents and food additives, in particular to a SiO 2 / Preparation and application of artemisinin antibacterial nanoparticles. Background technique [0002] Artemisia annua, also known as Artemisia annua L., is a plant of the genus Artemisia in the Asteraceae chamomile family; artemisinin is a sesquivalent peroxide group extracted by Chinese researchers in 1972 from the stems and leaves of the plant Artemisia annua L. Terpene lactone drug is an active ingredient that can treat malaria; artemisinin has various pharmacological effects such as antimalarial, immune regulation, antitumor and antibacterial; but because artemisinin is water-insoluble, it will make its antibacterial activity In practical application, this study focuses on solving the problem of water solubility of artemisinin, improving its water dispersibility, thereby improving its antibacterial activity and increasing its bioavailability. ...

Claims

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Application Information

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IPC IPC(8): A23L3/358A23L3/3472A23B4/24A23B4/20
CPCA23B4/20A23B4/24A23L3/3472A23L3/358
Inventor 林琳代娅婕崔海英
Owner JIANGSU UNIV
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