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Wuzhi soft capsule and preparation method thereof

A technology of soft capsules and schisandra, which is applied in the field of Wuzhi soft capsules and its preparation, can solve the problems of low content of active ingredients, inconvenient taking, and large dosage for patients, and achieve stable active ingredients, no damage to active ingredients, and simple structure Effect

Inactive Publication Date: 2016-12-07
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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  • Wuzhi soft capsule and preparation method thereof
  • Wuzhi soft capsule and preparation method thereof
  • Wuzhi soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1000g of schisandra chinensis, add 10 times the weight of the schisandra medicinal material in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of the medicinal material to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine and decoct twice Liquid, concentrated to a relative density of 1.05 at 60°C, adding ethanol to make the volume percentage of the alcohol content reach 75%, stirring, standing, and filtering, the relative density of the filtrate was 1.25 when the filtrate was concentrated to 65°C, and the ethanol was recovered to obtain a concentrated solution. Refined with macroporous resin, added to macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried, added vegetable oil, filled, and prepared into pentaester Softgels.

[0022] The preparation method of the five ester soft capsules, the model of the mac...

Embodiment 2

[0032]Take 1000g of schisandra chinensis, add 10 times the weight of the schisandra medicinal material in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of the medicinal material to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine and decoct twice Liquid, concentrated to a relative density of 1.05 at 60°C, adding ethanol to make the volume percentage of the alcohol content reach 75%, stirring, standing, and filtering, the relative density of the filtrate was 1.25 when the filtrate was concentrated to 65°C, and the ethanol was recovered to obtain a concentrated solution. Refined with macroporous resin, added to macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried, added vegetable oil, filled, and prepared into pentaester Softgels.

[0033] The preparation method of the five ester soft capsules, the model of the macr...

Embodiment 3

[0036] Take 1000g of schisandra chinensis, add 10 times the weight of the schisandra medicinal material in water, soak for 0.5h, decoct for 1 hour, filter, add 8 times the weight of the medicinal material to the dregs, decoct for 1 hour, filter out the medicinal liquid, combine and decoct twice Liquid, concentrated to a relative density of 1.05 at 60°C, adding ethanol to make the volume percentage of the alcohol content reach 75%, stirring, standing, and filtering, the relative density of the filtrate was 1.25 when the filtrate was concentrated to 65°C, and the ethanol was recovered to obtain a concentrated solution. Refined with macroporous resin, added to macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried, added vegetable oil, filled, and prepared into pentaester Softgels.

[0037] The preparation method of the five ester soft capsules, the model of the mac...

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Abstract

The invention provides a Wuzhi soft capsule. A preparation method comprises the following steps of selecting schisandra chinensis, adding water which is equal to 10 times of the schisandra chinensis in weight, soaking for 0.5h, decocting for 1h, filtering, adding water which is equal to 8 times of the schisandra chinensis in weight into medicine residues, decocting for 1h, filtering a medicine liquid, and the like. The Wuzhi soft capsule has the advantages that by adopting special concentration and drying equipment, the content of a mature fruit extract of the schisandra chinensis in the prepared Wuzhi soft capsule is high; application of the Wuzhi soft capsule in preparation of medicines for inhibiting CHL cell proliferation of Chinese hamster lung is found.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a five-ester soft capsule and a preparation method thereof. Background technique [0002] Wuzhi Soft Capsules can lower serum alanine aminotransferase and can be used for patients with elevated alanine aminotransferase in chronic hepatitis. It has a significant antagonistic effect on liver cell damage, can enhance the ability of liver cells to resist poisons, repair damage and resist mutations, promote the biosynthesis of proteins and glycogen in liver cells, accelerate the rate of amino acid penetration into the human liver, and improve the body's ability to respond The utilization of sugar improves the energy supply of the body and is conducive to the recovery of liver cell function. The preparation method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/48A61P1/16A61P35/00B01D1/00B01D1/14B01D1/30
CPCA61K9/4858A61K36/57A61K36/79A61K2236/331A61K2236/39A61K2236/55B01D1/00B01D1/0017B01D1/14B01D1/30
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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