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Polyvinyl alcohol graft polymer, its preparation method and hydrogel and its application

A technology of graft polymer and polyvinyl alcohol, applied in the field of polyvinyl alcohol graft polymer, can solve the problems of no reported temperature and pH double response groups, and achieve good drug sustained release performance, good reversible swelling and The effect of deswelling properties

Active Publication Date: 2018-10-09
珠海荣友新材料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above studies have successfully introduced temperature-responsive groups into PVA, but there is no previous report of directly grafting PVA with temperature and pH dual-responsive groups.

Method used

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  • Polyvinyl alcohol graft polymer, its preparation method and hydrogel and its application
  • Polyvinyl alcohol graft polymer, its preparation method and hydrogel and its application
  • Polyvinyl alcohol graft polymer, its preparation method and hydrogel and its application

Examples

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preparation example Construction

[0048] The application also provides the preparation method of described polyvinyl alcohol graft polymer, comprises the following steps:

[0049] mixing polyvinyl alcohol, a solvent and an activator to obtain activated polyvinyl alcohol;

[0050] reacting the activated polyvinyl alcohol with a compound of formula (IV) to obtain a polyvinyl alcohol graft polymer;

[0051]

[0052] Among them, R is the alkyl group of C1~C10, n 1 1 to 10.

[0053] The present application uses polyvinyl alcohol as a raw material to prepare a polyvinyl alcohol graft polymer containing carbamate groups and tertiary amine groups.

[0054]In the process of preparing the polyvinyl alcohol graft polymer, the applicant first activates the polyvinyl alcohol, that is, mixes the polyvinyl alcohol, a solvent and an activator, and reacts to obtain activated polyvinyl alcohol. The activator is preferably carbonyldiimidazole, and the solvent is preferably dimethylsulfoxide. The molar ratio of the polyvin...

Embodiment 1

[0067] Add 5 g of polyvinyl alcohol into 200 mL of dimethyl sulfoxide solvent, and after fully dissolving, add 9.2 g of carbonyldiimidazole and stir for 0.5 h at room temperature (20-30°C) to obtain activated polyvinyl alcohol;

[0068] Slowly add 8 mL of N,N-diethyl-1,2-diamine to the activated polyvinyl alcohol (for 10 min), and stir at room temperature for 10 h, 30 h, 70 h and 90 h respectively to obtain different carbamic acid- The polyvinyl alcohol graft polymer of diethyl-diamine substitution ratio;

[0069] After the reaction was completed, the obtained polyvinyl alcohol grafted polymer was added to 50 mL of 20% ammonia water, and stirred for 0.5 h so as to remove unreacted carbonyldiimidazole; subsequently, by adding a large amount of acetone, the product was precipitated in the form of a white precipitate, filtered, collected, In order to further purify the product, dialysis was used to dialyze the product against water for 48 hours.

[0070] figure 1 It is the prep...

Embodiment 2

[0078] The PVA-DEEDA-90h prepared in the above example was reacted with borax at a molar ratio of 1:0.4 to obtain a PVA-DEEDA-90h hydrogel. Such as Figure 6 as shown, Figure 6 It is the structural formula of PVA-DEEDA-90h hydrogel ( Figure 6 a) with the physical picture ( Figure 6 b).

[0079] Such as Figure 7 as shown, Figure 7 It is the curve graph of PVA-DEEDA-90h hydrogel swelling and deswelling process, by Figure 7 It can be seen that the hydrogel exhibits good reversible swelling and deswelling properties. After swelling, the water adsorption capacity is 1.25 times of the original weight.

[0080] Taking rhodamine as a model drug, the application of the above-mentioned hydrogel in drug sustained release was studied, and the drug release kinetics of the hydrogel was specifically studied, such as Figure 8 and Figure 9 as shown, Figure 8 is the rhodamine release rate curve of PVA-DEEDA-90h hydrogel at different temperatures, Figure 9 It is the rhodamine...

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Abstract

The invention provides a polyvinyl alcohol graft polymer with a formula (I) structure. The polyvinyl alcohol graft polymer has temperature and pH double-response properties simultaneously. When the polyvinyl alcohol graft polymer is applied to a pH environment and different graft alternative materials, the polymer shows different cloud point temperatures. The invention further provides a hydrogel. The hydrogel is prepared by the polyvinyl alcohol graft polymer and a crosslinking agent. The hydrogel can be applied in drug load and has a potential application value in the field of biological medicines such as slow drug release.

Description

technical field [0001] The invention relates to the technical field of high molecular polymers, in particular to polyvinyl alcohol grafted polymers, a preparation method thereof, hydrogel and applications thereof. Background technique [0002] Responsive hydrogels can be fabricated by physically or chemically crosslinking polymers. This type of hydrogel exhibits various high responses to temperature, pH, light, electricity, and magnetism, so it is widely used in the fields of biomedicine (such as tissue engineering, drug sustained release, etc.), liquid chromatography, and biosensors. a variety of applications. [0003] At present, responsive polymer materials have been commercialized. For example, hydrogels with the lowest critical solution temperature (LCST) have been used as drug carriers to achieve sustained drug release; at lower temperatures, LCST hydrogels are hydrophilic and can stably exist in blood; when the temperature As the LCST increases, the LCST hydrogel b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F8/32C08F116/06C08J3/24C08J3/075A61K9/06A61K47/32C08L29/04
CPCA61K9/06A61K47/32C08F8/32C08J3/075C08J3/24C08J2329/04C08F116/06
Inventor 高粱孔腾飞霍延平张力
Owner 珠海荣友新材料技术有限公司
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