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A kind of peg type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and application

A composite hydrogel and polythiourethane technology, applied in medical science, instruments, glasses/goggles, etc., can solve problems such as shedding, achieve good biocompatibility, wide sources, and reduce costs

Inactive Publication Date: 2018-08-03
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As early as 1789, French surgeon De Quengsy proposed the idea of ​​replacing cloudy cornea with glass. In 1856, Von Nussbaum and Neptuk implanted glass into rabbit eyes for the first time. In 1859, Heusser completed the first artificial cornea made of glass. Surgery to implant in a patient's eye, but eventually dislodge due to extrusion

Method used

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  • A kind of peg type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and application
  • A kind of peg type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and application
  • A kind of peg type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of PEG type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material, comprising the steps of:

[0033]S1. According to MDI, PEG200 dimercaptoacetic acid ester and HEMA molar ratio 3:2:2, the total mass of the three is 1g and the solid content after the three are dissolved in DMF solvent is 12.8% (DMF solvent is 6.8 times the total mass of the three solutes ), calculate the consumption of each raw material and solvent, add the three-necked flask with the calculated amount of dimercaptoacetic acid PEG200 ester and 3.4g DMF, the calculated amount of MDI and the 3.4gDMF are added dropwise, under argon, stirring and temperature React for 5 hours at 30°C. After 5 hours of reaction, add the calculated amount of HEMA, and react for 2 hours under argon gas, stirring, and temperature at 80°C to ensure that the double bonds are terminated. Use a dialysis bag with a molecular weight of 500 for 5 days to remove unresolved impurities. For the small...

Embodiment 2

[0037] A preparation method of PEG type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material, comprising the steps of:

[0038] S1. According to MDI, PEG200 dimercaptoacetic acid ester and HEMA molar ratio 2.5:2.0:1.0, the total mass of the three is 1g and the solid content after the three are dissolved in DMF solvent is 10% (DMF solvent is 9 times the total mass of the three solutes ), calculate the consumption of each raw material and solvent, add the three-necked flask with the calculated amount of dimercaptoacetic acid PEG400 ester and 4.5g DMF, the calculated amount of MDI and the 4.5g DMF are added dropwise, under argon, stirring and React for 3 hours at a temperature of 65°C. After 3 hours of reaction, add the calculated amount of HEMA, and react for 4 hours under argon gas, stirring, and a temperature of 60°C to ensure that the double bonds are terminated, and use a dialysis bag with a molecular weight of 500 for 5 days to remove For unreacted small m...

Embodiment 3

[0042] A preparation method of PEG type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material, comprising the steps of:

[0043] S1. According to MDI, PEG200 dimercaptoacetic acid ester and HEMA molar ratio 3.5:2.0:3.0, the total mass of the three is 1g and the solid content after the three are dissolved in DMF solvent is 20% (DMF solvent is 4 times the total mass of the three solutes ), calculate the consumption of each raw material and solvent, add the three-necked flask with the calculated amount of dimercaptoacetic acid PEG200 ester and 2g DMF, the calculated amount of MDI and 2gDMF are added dropwise, under argon, stirring and temperature at 80 React for 2 hours at ℃. After 2 hours of reaction, add the calculated amount of HEMA, and react for 3 hours under argon, stirring and temperature at 50℃ to ensure that the double bonds are terminated. Use a dialysis bag with a molecular weight of 500 for 5 days to remove unreacted For small molecular monomers, 1:1 ...

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Abstract

The invention belongs to the field of polymers and relates to a PEG-type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and use. The preparation method comprises that S1, in DMF as a solvent, glycol dimercaptoacetate and a diisocyanate monomer undergo a reaction to produce polythiourethane, HEMA is added into the polythiourethane, and the mixed solution undergoes a reaction to produce double bond-terminated PEG-type polythiourethane, S2, the double bond-terminated PEG-type polythiourethane, an acrylic acid monomer and ME-ZnS are dissolved in DMF, the solution is subjected to ice-bath ultrasonic treatment, a photoinitiator and a cross-linking agent are added into the mixed solution and the mixed solution is subjected to ultrasonic treatment so that a precursor solution is obtained, and S3, the precursor solution is poured on a polyfluortetraethylene plate, a plate covers the polyfluortetraethylene plate and the plates are irradiated through UV so that a polymerization reaction occurs and the PEG-type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material is obtained. The composite hydrogel material has high balanced water content and a high refractive index and has application prospects in the fields of a soft contact lens body material or an artificial cornea implant material.

Description

technical field [0001] The invention belongs to the field of polymer materials, in particular to a PEG-type polythiourethane-acrylic acid-zinc sulfide composite hydrogel material and its preparation method and application. Background technique [0002] The cornea is composed of three layers of cells responsible for different functions: the outermost layer is multilayered epithelial cells for protection; the middle layer is corneal stromal cells composed of 78% water and 16% collagen; the innermost layer is for A single inner testa that controls fluid and solute transport and maintains water balance to ensure optical clarity. As early as 1789, French surgeon De Quengsy proposed the idea of ​​replacing cloudy cornea with glass. In 1856, Von Nussbaum and Neptuk implanted glass into rabbit eyes for the first time. In 1859, Heusser completed the first artificial cornea made of glass. Surgery to implant in a patient's eye, but eventually dislodge due to extrusion. In 1905, the G...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/00C08F220/06C08G18/76C08G18/73C08G18/38C08G18/50C08G18/67C08K9/04C08K3/30A61L27/52A61L27/02A61L27/16G02C7/04
CPCA61L27/025A61L27/16A61L27/52A61L2430/16C08F283/008C08G18/3876C08G18/5072C08G18/672C08G18/73C08G18/7671C08K3/30C08K9/04C08K2003/3036G02C7/049C08F220/06C08L51/08
Inventor 张全元曾有兰张博晓孙鹏陆文浩胡成袁天梦唐雪晴徐祖顺
Owner HUBEI UNIV