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Amoxicillin superfine powder water-soluble preparation and preparation method thereof

A technology of amoxicillin and ultrafine powder, which is applied to the formulation of amoxicillin ultrafine powder water-soluble preparation and the field of preparation thereof, can solve the problems of secondary pollution of the environment, large toxic and side effects of drugs, large drug dosage, etc., and achieves low equipment requirements. , the effect of fast drug metabolism and low dosage

Inactive Publication Date: 2017-01-11
XIAN LUCKYROAD BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the amoxicillin veterinary drug preparations produced by the prior art have high water content, high impurities, large drug side effects, poor stability, large drug consumption, and slow metabolism, which easily cause secondary pollution to the environment.

Method used

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  • Amoxicillin superfine powder water-soluble preparation and preparation method thereof
  • Amoxicillin superfine powder water-soluble preparation and preparation method thereof
  • Amoxicillin superfine powder water-soluble preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of water-soluble preparation of amoxicillin superfine powder processed by low-temperature air flow, including 25% amoxicillin, 30% PVPK30, 30% PEG6000, 12% L-arginine, 3% Tween in terms of mass percentage -80.

[0023] The preparation method of this amoxicillin superfine powder water-soluble preparation is as follows:

[0024] Step 1: Amoxicillin accounts for 25% by mass of the superfine powder water-soluble preparation, PVPK30 accounts for 30% by mass of the water-soluble preparation, PEG6000 accounts for 30% by mass of the water-soluble preparation, and L-arginine accounts for 30% by mass of the preparation Amoxicillin, PVPK30, PEG6000, L-arginine, and Tween 80 were weighed according to the standard that 12% of Tween-80 accounted for 3% of the mass percentage of the preparation.

[0025] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0026] Step 3: The uniformly mixed material enters the classifier through the fe...

Embodiment 2

[0028] A kind of water-soluble preparation of amoxicillin superfine powder processed by low-temperature air flow, comprising 30% amoxicillin, 25% PVPK30, 30% PEG6000, 14% L-arginine, 1% Tween in terms of mass percentage 80.

[0029] The preparation method of this amoxicillin superfine powder water-soluble preparation is as follows:

[0030] Step 1: Amoxicillin accounts for 30% by mass of the superfine powder water-soluble preparation, PVPK30 accounts for 25% by mass of the water-soluble preparation, PEG6000 accounts for 30% by mass of the water-soluble preparation, and L-arginine accounts for 30% by mass of the preparation Amoxicillin, PVPK30, PEG6000, L-arginine, and Tween 80 were weighed according to the standard that 14% of Tween-80 accounted for 1% of the mass percentage of the preparation.

[0031] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0032] Step 3: The uniformly mixed material enters the classifier through the fe...

Embodiment 3

[0034] A kind of water-soluble preparation of amoxicillin superfine powder processed by low-temperature air flow, including 29% amoxicillin, 26% PVPK30, 30% PEG6000, 13% L-arginine, 2% Tween 80.

[0035] The preparation method of this amoxicillin superfine powder water-soluble preparation is as follows:

[0036] Step 1: Amoxicillin accounts for 29% by mass of the superfine powder water-soluble preparation, PVPK30 accounts for 26% by mass of the water-soluble preparation, PEG6000 accounts for 30% by mass of the water-soluble preparation, and L-arginine accounts for the mass percent of the preparation Amoxicillin, PVPK30, PEG6000, L-arginine, and Tween 80 were weighed according to the standard that 13% of Tween-80 accounted for 2% of the mass percentage of the preparation.

[0037] Step 2: Place the weighed raw and auxiliary materials in a mixer and mix for 30-60 minutes.

[0038] Step 3: The uniformly mixed material enters the classifier through the feeding device for process...

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Abstract

The invention discloses a formulation and a preparation method of an amoxicillin superfine powder water-soluble preparation and belongs to the technical field of veterinary medicine preparation. The amoxicillin superfine powder water-soluble preparation is soluble powder and comprises, by mass, 15-35% of amoxicillin, 15-35% of PVPK30, 15-35% of PEG6000, 5-20% of L-arginine and 1-5% of Tween-80. The amoxicillin superfine powder water-soluble preparation is non-degradable, specific surface area is increased, the preparation can be dispersed well and is easier to absorb, dissolution rate of amoxicillin is increased greatly, and the preparation is low in water content and impurity content. Acceleration experiments and long-time experiments show that the preparation has high stability. Pharmacological experiments find that the preparation has treatment effect on chicken salpingitis obviously better than common amoxicillin soluble powder, healing rate reaches 85.3%, and effective rate reaches 91.0%.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a formula of amoxicillin superfine powder water-soluble preparation and a preparation method thereof. Background technique [0002] In recent years, the abuse of antibiotics is very common, and the problem of bacterial resistance is becoming more and more serious. In order to treat animals, antibiotics usually need to be increased several times to achieve a certain effect. The use of large doses of antibiotics leads to the inability of drugs to be metabolized in animals. It is excreted, causing secondary pollution to water sources, soil and other environments. In order to prevent and control animal diseases, promote the healthy development of the breeding industry, maintain human health, and minimize the excretion of drug residues. Clinically, there is an urgent need to supplement or replace antibacterial drugs with less dosage, fast drug metabolism, defi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/43A61K47/32A61K47/10A61K47/18A61K47/26A61P31/04A61P15/08
CPCA61K9/146A61K9/145A61K31/43
Inventor 景战蕾杨艺吴小宁
Owner XIAN LUCKYROAD BIOLOGICAL TECH
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