A kind of bone filling adhesive and its preparation method and application

Abstract

The invention discloses a bone filling adhesive which has good biocompatibility and is convenient to implant, and a preparation method of the bone filling adhesive as well as application of the bone filling adhesive. The bone filling adhesive is characterized by being made from PLGA (poly(lactic-co-glycolic acid)), ethyl acetate, biological glue, a phosphate buffer and distilled water serving as raw materials according to the ratio, wherein ethyl acetate can be replaced by acetone or dichloromethane, the bone filling adhesive is prepared by the steps of dissolving PLGA intoethyl acetate or acetone or dichloromethane, and dissolving the biological glue into the phosphate buffer. The bone filling adhesive is added into a solvent, and after being dissolved, the bone filling adhesive is implanted in an injection manner. The bone filling adhesive has the beneficial effects that when bone fractures are treated, the bone filling adhesive is added into the solvent and the mixture is implanted in an injection manner by utilizing good biodegradability and biocompatibility of the PLGA and the biological glue, and the implantation manner is accurate, convenient and fast; the bone filling adhesive is capable of promoting and adjusting growth and differentiation of subperiosteal peripheral cells, accelerating formation of bone matrixes and a mineralizing biological mechanism, quickly healing the bone fractures and quickly fixing and supporting bone fracture parts; and the bone filling adhesive can be proliferated and disintegrated into bone generating cells, has good bone conduction property and is absorbed into bone fracture areas to form calluses and further repair the bone fractures.

Description

technical field [0001] The invention relates to the technical field of biological preparations, in particular to a bone filling adhesive and its preparation method and application. Background technique [0002] A fracture is a complete or partial break in a bone or the structure of a bone. It is more common in children and the elderly, and also occurs in young and middle-aged people. Fractures are quite common injuries. In order to make the broken bone grow well, restore the original support and protect the motor function, the broken ends must first be connected and the position should be adjusted, which is called reset in medicine. The better the reduction, the more conducive to the growth and healing of the bone at the fracture site, and the better the functional recovery in the future. There are two basic methods of reduction, namely manual reduction and surgical reduction. In the former, the doctor uses techniques such as pulling, pulling, lifting, lifting, squeezing...

AI Technical Summary

Problems solved by technology

Although the traditional inorganic calcium phosphate bone cement has good biocompatibility and high bioactivity, its mechanical strength is too low, its compressive strength is low, its tensile strength is low, its brittleness is high, and its elastic modulus is greatly high. in natural bone

In addition, its injectability is poor, and it cannot accurately fill and repair the place that needs to be treated according to the defect site, and there are also problems such as difficulty in solidifying body fluids and blood.

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