Application of epiberberine in preparation of urease inhibitor

A technology of urease inhibitor and epiberberine, which is applied in the field of original berberine compounds, can solve the problems of obvious toxic side effects, short action time, poor stability, etc., and achieve the effect of clear inhibition mechanism and abundant sources

Active Publication Date: 2017-01-18
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing urease inhibitors have problems such as poor stability, short action

Method used

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  • Application of epiberberine in preparation of urease inhibitor
  • Application of epiberberine in preparation of urease inhibitor
  • Application of epiberberine in preparation of urease inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0095] Embodiment 1 (capsule)

[0096] Epiberberine 10g and starch 300g mix evenly, use 7% starch slurry 300g as binder, wet granulation, dry, add magnesium stearate 16g and mix, make epiberberine capsule content; Fill capsule , the specification is 1000 capsules each containing 10mg of epiberberine, and the net weight of each capsule is 0.31g. 1-2 capsules each time, 3 times a day, 10-15 days as a course of treatment, can be used continuously for 2-3 courses. It is used orally during the treatment of Helicobacter pylori-related gastrointestinal diseases such as peptic ulcer, gastritis, gastric mucosal lymphoma, and even gastric cancer.

Example Embodiment

[0097] Embodiment 2 (capsules)

[0098] Epiberberine 1g and starch 300g mix evenly, use 7% starch slurry 300g as binder, wet granulation, dry, add magnesium stearate 16g and mix, make epiberberine capsule content; Fill capsule , the specification is 1000 capsules each containing 1mg of epiberberine, and the net weight of each capsule is 0.30g. 1-2 capsules each time, 3 times a day, 10-15 days as a course of treatment, can be used continuously for 2-3 courses. It is used orally during the treatment of Helicobacter pylori-related gastrointestinal diseases such as peptic ulcer, gastritis, gastric mucosal lymphoma, and even gastric cancer.

Example Embodiment

[0099] Embodiment 3 (capsules)

[0100] Epiberberine 100g and starch 300g mix evenly, use 7% starch slurry 300g as adhesive, wet granulation, dry, add magnesium stearate 16g and mix, make epiberberine capsule content; Fill capsule , the specification is 1000 capsules each containing 100mg of epiberberine, and the net weight of each capsule is 0.30g. 1 capsule each time, 3 times a day, 10-15 days as a course of treatment, can be used continuously for 2-3 courses. It is used orally during the treatment of Helicobacter pylori-related gastrointestinal diseases such as peptic ulcer, gastritis, gastric mucosal lymphoma, and even gastric cancer.

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PUM

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Abstract

The invention relates to application of epiberberine in preparation of a urease inhibitor. In application, urease can becanavalia ensiformis urease and can be also helicobacter pylori. The urease inhibitor is granules, capsules or tablets. The urease inhibition effect of the epiberberine is remarkably better than that of recognized acetylhydroxamic acid.

Description

technical field [0001] The present invention relates to heterocyclic compounds, in particular to protoberberine compounds. Background technique [0002] Urease (Urease, EC 3.5.1.5, Ure), also known as urea amidohydrolase, is a nickel-containing ion (Ni 2+ ) metalloenzymes. Urease catalyzes the hydrolysis of urea to ammonia and thus plays an important role in nitrogen metabolism. However, if the activity of urease is too high, the catalytic hydrolysis of urea will be too fast, and a large amount of ammonia gas will be released, which will bring various hazards to agriculture, animal husbandry, the environment and even human health. In agriculture, urease catalyzes the hydrolysis of urea into ammonia too quickly, which will lead to the volatilization of ammonia and the excessive accumulation of nitrate ions and ammonium ions in the soil, thereby reducing the utilization rate of ammonia and polluting the atmosphere, water, soil and other environments; In animal husbandry, no...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P31/04A61P1/00A61P1/04A61P35/00
CPCA61K31/4375
Inventor 苏子仁谢建辉黎玉翠赖小平李彩兰谈丽华
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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