Application of high-strength acryloyl-glycinamide-based hydrogel as thermoplastic polymer

A technology of acryloyl glycinamide and thermoplastic polymers, applied in medical science, prostheses, etc., can solve the problems of high tensile and compression resistance, and achieve good biocompatibility, good mechanical strength and toughness Effect

Inactive Publication Date: 2017-01-18
TIANJIN UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

But these high-strength hydrogels do not have both high tensile and compressive properties (Yoshimi Tanaka, JainPing Gong, Yoshihito Osada. Novel hydrogels with excellent mechanicalperformance. (MMC)
But these high-strength hydrogels do not have high tensile and compressive properties (Yoshimi Tanaka, Jain Ping Gong, Yoshihito Osada. Novel hydrogels with excellent mechanical performance. Prog. Polym. Sci. 2005; 30: 1-9.)

Method used

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  • Application of high-strength acryloyl-glycinamide-based hydrogel as thermoplastic polymer
  • Application of high-strength acryloyl-glycinamide-based hydrogel as thermoplastic polymer
  • Application of high-strength acryloyl-glycinamide-based hydrogel as thermoplastic polymer

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Embodiment Construction

[0022] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0023] In the examples, glycinamide hydrochloride and acryloyl chloride were used as raw materials according to references (Boustta M, Colombo P E, Lenglet S, et al. Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery [J]. Journal of Controlled Release, 2014,174:1-6) prepared a monomer acryloyl glycinamide with two amide groups, the chemical formula structure is shown in the following chemical formula:

[0024]

[0025] Utilize Fourier transform infrared spectroscopy (U.S. Platinum Elmer Company) to prove its successful synthesis, wherein their characteristic peaks are as follows: ν=3389cm -1 (m,NH),3314cm -1 (s,NH),3191cm -1 (m,NH),1662cm -1 (vs, C=O), 1626cm -1 (vs, C=O), 1556cm -1 (vs, NH) (see attached figure 1 ).

[0026] Carry out homopolymerization with the acryloyl glycinamide synthesized abo...

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Abstract

The invention discloses application of a high-strength acryloyl-glycinamide-based hydrogel as a thermoplastic polymer, the high-strength acryloyl-glycinamide-based hydrogel is prepared from acryloyl glycinamide as an monomer in the presence of an initiator, due to the synergic effect of hydrogen bond, the hydrogel has very strong tensile and compression property, and can resist tear at the same time, at a relatively high temperature thermoplasticity and self-healing function can be implemented, and the hydrogel has very good biocompatibility.

Description

[0001] The application of the present invention is a divisional application of the parent application "a high-strength supramolecular hydrogel and its preparation method and application". The application date of the parent application is April 21, 2015, and the application number is 2015101916077. technical field [0002] The present invention relates to a kind of hydrogel and its preparation method, more specifically, relate to a kind of PNAGA hydrogel prepared with acryloyl glycinamide (NAGA) as a monomer and its preparation method, which has high stability, high strength, Thermoplastic and self-healing capabilities. Background technique [0003] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking between polymer chains, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/36C08J3/075A61L27/16A61L27/38A61L27/52A61L27/50
CPCA61L27/16A61L27/3817A61L27/50A61L27/52C08F120/36C08F122/38C08J3/075C08J2333/14C08J2335/00C08L33/14C08L35/00
Inventor 刘文广戴西洋张银宇
Owner TIANJIN UNIV
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