Bonelike porous biomechanical bionic designed spinal fusion device and preparation method and use thereof

A biomechanical and fusion device technology, applied in the field of biomedical materials, can solve the problems of dense titanium alloy stress shielding, implant stress absorption, and load inability to transmit, and achieve the effects of short manufacturing time, reduced cost, and good therapeutic effect.

Inactive Publication Date: 2017-01-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the mechanical properties of the bone tissue restoration do not match the natural bone tissue, the load cannot be transmitted between the implant and the adjacent bone tissue, resulting in stress absorption around the implant, which eventually leads to loosening and fracture of the implant and causes the application fail
Therefore, dense titanium alloys are prone to stress shielding, causing bone resorption

Method used

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  • Bonelike porous biomechanical bionic designed spinal fusion device and preparation method and use thereof
  • Bonelike porous biomechanical bionic designed spinal fusion device and preparation method and use thereof
  • Bonelike porous biomechanical bionic designed spinal fusion device and preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] In the modeling software, place nine spheres so that the positions of the centers of the spheres are strictly in accordance with the positions of atoms in the diamond structure in crystallography, where the radius of the spheres is 0.2mm, and then add dumbbell-shaped cylinders between each sphere with a minimum radius of 0.1mm. unit model see figure 1 , 3D model diagram of diamond cubic crystal structure microporous space structure unit body, figure 2 It is the 3D model figure after the microporous spatial structure unit body array of embodiment 1; image 3 It is an enlarged view of the microporous spatial structural unit body printed by SLM, and the microporous structural unit entity is printed by 5 times magnification.

[0032] Among them, the minimum tangential radius of the dumbbell-shaped cylinder is 50 μm, the length is 500 μm, and the diameter of the hole formed by the six cylinders is 900 μm; the porosity of the model is 84.2%, and the pore diameter is 860±20...

Embodiment 2

[0035] Modeling is carried out in the modeling method of Example 1, wherein the radius of the sphere is 0.25 mm, and other parameters remain unchanged. Using pure titanium spherical powder as raw material, the 3D model of the designed product was converted into an STL format file, and input into a 3D printer for printing. The resulting product had a porosity of 74.4% and a pore diameter of 800±15 μm. The maximum compressive strength of the product is 92.1MPa, equivalent to that of human cortical bone.

Embodiment 3

[0037]Modeling is carried out in the modeling method of Example 1, wherein the radius of the sphere is 0.25mm, the minimum diameter of the dumbbell-shaped cylinder is 0.08mm, and other parameters remain unchanged. Using pure titanium spherical powder as raw material, the 3D model of the designed product was converted into an STL format file, and input into a 3D printer for printing. The resulting product had a porosity of 80.2% and a pore diameter of 860±18 μm.

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Abstract

The invention relates to a bone-like porous biomechanical bionic design spine fusion device and its preparation method and application, which belong to the field of biomedical materials and are composed of a plurality of microporous spatial structural units, the microporous spatial structural unit is a regular tetrahedral structure, and the microporous The spatial structure unit body includes a base point and a filling geometry; the base point is located at the apex of the front tetrahedron; the filling geometry is arranged at the position of the base point, and the filling geometry intersects with the adjacent filling geometry to form a regular tetrahedral edge, and multiple microporous spatial structure units The shape, size and porosity of the pores of the material can be precisely adjusted to achieve the mechanical properties of natural bone matching. performance, and can be customized according to the needs of patients, with good biocompatibility, bioactivity, and biomechanical suitability, and has broad application prospects in orthopedic clinics.

Description

technical field [0001] The invention relates to a bone-like porous biomechanical bionic design spinal fusion device, a preparation method and application thereof, and belongs to the field of biomedical materials. Background technique [0002] Lumbar degenerative diseases such as spinal stenosis, spondylolisthesis, and intervertebral disc herniation are common spinal surgery diseases in recent years, which seriously affect the work and life of patients. Once drugs and physical non-surgical treatments fail, surgical treatment is often the only effective method . Since Bagby applied the intervertebral fusion device Cage to spinal fusion for the first time in 1988 and achieved success, various intervertebral fusion devices have come out one after another and have been widely accepted clinically. Human spinal bone tissue has complex morphology, individual size characteristics, and unique mechanical characteristics. How to accurately reconstruct and prepare a fusion cage that ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44A61L27/06A61L27/32A61L27/50A61L27/56B33Y80/00
CPCA61F2/4455A61F2230/0089A61F2240/001A61F2250/0024A61F2310/00023A61F2310/00796A61L27/06A61L27/32A61L27/50A61L27/56A61L2430/02B33Y80/00
Inventor 周长春裴玄樊渝江张勃庆王亚宁胡晓兵殷国富张兴栋
Owner SICHUAN UNIV
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