Method for forming composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for femoral head and neck

A technology of elastic modulus and rhbmp-2, which is applied in the fields of medical science and prosthesis, can solve the problems of not taking into account the changing characteristics of the femoral head and neck, affecting the bone repair and reconstruction of the support rod, and the complicated preparation process of the porous tantalum rod. Achieve stable osteoinductive performance, avoid stress shielding effect, and good osteoconductivity
CN101905032BInactive Publication Date: 2013-06-05FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2013-06-05
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a method for forming a composite rhBMP-2 elasticity modulus graded porous titanium alloy support rod for the femoral head and the neck. Titanium alloy powder is prepared with an electrode induction melting gas atomization method, and the integrated elasticity modulus graded porous titanium alloy support rod consisting of a head part, a body part and a tail part is prepared according to actually measured biomechanical parameters of the femoral head, the neck and a rotor, wherein the head part and the body part are prepared by sintering the titanium alloy powder and pore-forming agents through the adoption of a cold rolling method, the tail part is prepared by directly sintering the titanium alloy powder, and the porous titanium alloy support rod is immersed in a rhBMP-2 / gelatin controlled release microsphere solution. The product prepared by the method can simulate the biomechanical properties of the femoral head and the neck of a human body to the utmost extent, thereby being beneficial to the stress transfer between materials and bone tissue interfaces, avoiding poor bone restoration caused by the stress shielding effect; and simultaneously, sustained-release microspheres on which bone induced growth factors (rhBMP-2) are loaded endue the materials per se with good bone conductivity.
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Description

technical field

[0001] The invention relates to a preparation method of a support rod for treating early-stage avascular necrosis of the femoral head, in particular to a construction method of a rhBMP-2 composite rhBMP-2 elastic modulus gradient porous titanium alloy support rod for the neck of the femoral head. Background technique

[0002] Avascular necrosis of the femoral head is a common orthopedic disease in young and middle-aged people. As the disease progresses, 60-80% of patients have to undergo total hip arthroplasty due to femoral head collapse, deformation and traumatic arthritis, which causes great losses to the patients themselves, their families and society. Improper or untimely treatment of femoral head necrosis is the main reason for this consequence. At present, there are many methods to prevent early femoral head necrosis and femoral head collapse, mainly including restrictive weight bearing, intramedullary decompression, free fibula transplantation, and s...

Claims

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