Biomedical degradation-absorption-controllable macromolecule metal composite implantation material and use thereof

A polymer material, biomedical technology, applied in the field of biomedical composite materials and metal implant materials, can solve the problems of degradation time and strength, rigidity mismatch, poor processing stability and storage stability, and poor degradation controllability, etc. To achieve the effect of being beneficial to healing, easy to control the degradation rate, and improve the strength

Inactive Publication Date: 2008-04-16
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After years of clinical application of biodegradable polymer materials, many problems have been found [1-3] : (1) Low strength, low hardness and rigidity; (2) Poor degradation controllability, degradation time and strength, rigidity do not match, and the strength decreases rapidly during the degradation process, resulting in premature failure of the device; (3) Accumulation of local acidic degradation products Cause non-specific inflammation and affect healing; (4) During the sterilization and disinfection process of gamma rays or ethylene oxide (EO), the mechanical properties are reduced; (5) Poor processing stability and storage stability

Method used

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  • Biomedical degradation-absorption-controllable macromolecule metal composite implantation material and use thereof
  • Biomedical degradation-absorption-controllable macromolecule metal composite implantation material and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Use some 99.95% pure magnesium filaments (after polishing, the wire diameter is 0.5mm), ultrasonically clean them in acetone and alcohol for 5 minutes, dry them in a vacuum oven, put them into a customized mold, and add molten poly Lactic acid (PLA), the volume ratio of pure magnesium wire is about 30%, processed into a test sample (30mm×20mm×3mm) after cooling, soaked in the simulated plasma solution prepared according to Table 1 and corroded completely after about 6 months degradation.

[0019] Since the corrosion rate of pure magnesium materials can be adjusted by factors such as impurity content, grain size and heat treatment, the degradation rate of polylactic acid can also be controlled according to the molecular weight of polylactic acid and the thickness of the coating, so according to the above process The medical Controllable Degradation The degradation rate of pure magnesium-polylactic acid composites can be optimized and adjusted from both pure magnesium and...

Embodiment 2

[0023] After polishing 12 as-cast AZ31B magnesium alloy 2mm rods, they were ultrasonically cleaned in acetone and alcohol for 5 minutes, dried in a vacuum oven, and then made into composite materials with polyglycolic acid (PGA). AZ31B magnesium alloy rods The proportion is about 30%, and a test sample (40mm×30mm×6mm) is made, soaked in 0.9% NaCl solution for about 9 months and then completely corroded and degraded.

[0024] Since the corrosion rate of the AZ31B magnesium alloy material can be adjusted by factors such as impurity content, grain size and heat treatment, the degradation rate of polyglycolic acid can also be controlled according to the molecular weight and the thickness of the coating, so the medical can be prepared according to the above process. Controlled degradation The degradation rate of magnesium alloy materials can be optimized and adjusted from two aspects of alloy matrix and surface polyglycolic acid and their ratio.

Embodiment 3

[0026] Ultrasonic cleaning of high-purity magnesium (99.99%) chips in acetone and alcohol for 5 minutes, drying in a vacuum oven, and then compounding with a copolymer of polylactic acid and polyglycolic acid (PLGA), the proportion of magnesium chips is about 40%, A test sample (35mm×20mm×3mm) was made, and it was completely corroded and degraded after soaking in 0.9% NaCl solution for about 4 months.

[0027]Since the corrosion rate of pure magnesium materials can be adjusted by factors such as impurity content, grain size and heat treatment, the degradation rate of the copolymer of polylactic acid and polyglycolic acid can also be controlled according to the ratio of the two and the thickness of the coating, so The degradation rate of the medical controllable degradable magnesium alloy material prepared by the above process can be optimized and adjusted from the two aspects of alloy matrix and surface polylactic acid and polyglycolic acid.

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Abstract

The invention discloses a biological medical planting material and composite material and application of controllable decomposable macromolecular metal, which is characterized by the following: adopting decomposable macromolecular material as base and pure magnenium and alloy with bulk percentage at 5-50% from board, rod, pipe, filament, whisker and porous material as reinforcer, improving dynamical property in the composite material, controlling decomposing period effectively.

Description

technical field [0001] The invention relates to a biomedical composite material and a metal implant material, in particular to a biomedical controllable degradation absorption polymer metal composite implant material and its application. Background technique [0002] Many medical implants (such as cardiovascular stents, bone nails and bone plates, etc.) cannot stay in the body for a long time after the expiration of their service, and need to be removed by surgery again. Degradable medical materials can be gradually degraded and absorbed and metabolized by the body under the physiological environment in the body, so they are more suitable for implantation in the human body. The biodegradable materials currently used in clinical practice are mainly polymer materials, such as collagen, polylactic acid, etc., and bone needles, drug controlled release carriers, and scaffolds made of them have been commercialized. [0003] After years of clinical application of biodegradable pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/00A61L27/00
Inventor 任伊宾杨柯黄晶晶张炳春姚治铭
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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