Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Diflunisal film coating agent and preparation method thereof

A technology of diflunisal and film coating agent is applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., which can solve problems such as the preparation of diflunisal film coating agents that have not yet been seen, and achieve drug transdermal Strong absorption capacity, enhanced curative effect, and high elasticity

Inactive Publication Date: 2017-02-01
CHENGDU XIANXIANXIAN BIOTECH CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage forms used in clinical practice are mainly tablets, but there is no preparation of diflunisal film-coating agent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] The diflunisal coating agent of the present embodiment, weight portion represents, diflunisal 3g, chitosan 10g, glycerin 100g, lauryl nitrogen 5g, 600ml purified water, enough ethanol solution.

[0022] Wherein, the chitosan is a chitosan with a viscosity of 50 mPa·s and a deacetylation degree of not less than 80%; the ethanol solution is an ethanol solution with an ethanol concentration of 75%.

[0023] A preparation method of diflunisal coating agent, comprising the following steps:

[0024] (1) Take 600 mL of purified water, scatter 10 g of chitosan evenly on the surface of the purified water to make it swell naturally, then add 5 g of polyvinyl alcohol, stir evenly, and obtain a film-forming matrix;

[0025] (2) Get 100g glycerin, add in 300mL ethanol solution, then add 3g diflunisal to make it dissolve, add in the film-forming matrix in step (1);

[0026] (3) Add ethanol to 1000ml, and stir well to obtain diflunisal film-coating agent.

[0027] Wherein, the sti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a diflunisal film coating agent. The diflunisal film coating agent is prepared from, by weight, 1-5 g of diflunisal, 5-15 g of chitosan, 80-150 g of glycerin, 2-7 g of azone, 200-800 ml of purified water and a full dosage of an ethyl alcohol solution. A preparation method of the diflunisal film coating agent comprises the following steps that 1, the chitosan is uniformly dispersed into the surface of purified water, natural soluble inflation is performed, polyvinyl alcohol is added, and stirring is performed to obtain a film formation matrix; 2, diflunisal is added in a glycerin ethyl alcohol solution to be dissolved, and the mixture is added into the film formation matrix in the step 1; 3, ethyl alcohol is added to reach the volume of 1,000 ml, sufficient stirring is performed, and the diflunisal film coating agent is obtained. According to the diflunisal film coating agent, on the basis of partial skin dosage, the liver first-pass effect and the gastrointestinal tract effect are overcome, the bioavailability is improved, and the curative effect is enhanced; the preparation method is reasonable, the content measuring method is high in specificity, the result is accurate, and it is indicated that the established standard can be used for quality control over preparations.

Description

technical field [0001] The invention relates to the technical field of preparation of coating agents, in particular to a diflunisal coating agent and a preparation method thereof. Background technique [0002] Film-coating agent is a new dosage form researched and developed in the field of preparations in recent years. It is an external preparation made by dissolving film-forming materials and drugs with solvents. When applied to the affected area, the thin film formed after the solvent volatilizes can protect the wound surface, and at the same time gradually release the contained medicine to achieve therapeutic effect, and can minimize the pain during the use and removal of traditional dressings and bandages. The preparation process is simple, convenient to use, and can avoid the first-pass effect of the liver. [0003] Diflunisal is the first propionic acid precursor non-steroidal anti-inflammatory drug. It has strong analgesic effect, rapid onset, and balanced analgesic,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/70A61K31/603A61K47/36A61K47/22A61K47/10A61P29/00A61P19/02
CPCA61K9/7015A61K31/603A61K47/10A61K47/22A61K47/36
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com