Check patentability & draft patents in minutes with Patsnap Eureka AI!

Application of acetytastragaloside

A technology of astragaloside and acetyl, applied in the application field of acetyl astragaloside, can solve problems such as no reports on the application of acetyl astragaloside, and achieve the effects of prolonging survival time, improving survival rate, and reducing death

Active Publication Date: 2017-02-08
JIANGSU KANION PHARMA CO LTD
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There is no report on the application of acetyl astragaloside in the preparation of drugs for the prevention and / or treatment of hand, foot and mouth disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of acetytastragaloside
  • Application of acetytastragaloside
  • Application of acetytastragaloside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Anti-hand-foot-mouth virus activity experiment of acetyl astragaloside in vitro

[0057] 1. Experimental materials:

[0058] Coxsackievirus A16 (Cox A16) and Enterovirus 71 (EV71), provided by the Institute of Microbial Epidemiology and Immunology, Academy of Military Medical Sciences of the Chinese People's Liberation Army, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, in Vero cells Passage in culture and store at -80°C.

[0059] African green monkey kidney cells (Vero cells) were purchased from the ATCC cell bank in the United States and preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute.

[0060] DMEM medium, purchased from Nanjing Kaiji Biotechnology Development Co., Ltd., batch number: 20141024, cell growth medium containing 10% fetal bovine serum, 1 × 10 5 U / L penicillin, 100mg / L streptomycin. The cell maintenance solution is the same as the cell growth solution except 2% fetal bovine serum. Acetyl as...

Embodiment 2

[0069] Example 2 The therapeutic effect of acetylastragaloside on enterovirus EV 71 infection

[0070] 1. Experimental materials:

[0071] Enterovirus 71 (EV71), provided by the Institute of Microbial Epidemiology and Immunology, Academy of Military Medical Sciences of the Chinese People's Liberation Army, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, passaged in Vero cell culture, and preserved at -80°C.

[0072] SPF grade BALB / c pregnant mice with 15-16 days of pregnancy were purchased from Qinglongshan Experimental Animal Breeding Farm, Jiangning District, Nanjing City, and were raised in an IVC system (temperature 18-28°C, relative humidity 40-70%, mechanical ventilation; Light and dark cycle: 12h / 12h; 150-300Lux illumination), 3-day-old neonatal mice were used for the experiment.

[0073] Ribavirin was purchased from Harbin Pharmaceutical Sanjing Pharmaceutical Co., Ltd., approved by the National Medicines Agency H19993937, specification: 1ml:...

Embodiment 3

[0084] Example 3 Therapeutic effect of acetylastragaloside on Coxsackie virus A16 infection

[0085] 1. Experimental materials:

[0086] Coxsackievirus A16 (Cox A16) was provided by the Institute of Microbial Epidemiology and Immunology, Academy of Military Medical Sciences of the Chinese People's Liberation Army, preserved by Jiangsu Kangyuan Modern Chinese Medicine Research Institute, passaged in Vero cell culture, and preserved at -80°C.

[0087] SPF grade BALB / c pregnant mice with 15-16 days of pregnancy were purchased from Qinglongshan Experimental Animal Breeding Farm, Jiangning District, Nanjing, and were raised in an IVC system (temperature 18-28°C, relative humidity 40-70%, mechanical ventilation; Light and dark cycle: 12h / 12h; 150-300Lux illumination), 3-day-old newborn suckling mice were used for the experiment.

[0088] Ribavirin was purchased from Harbin Pharmaceutical Sanjing Pharmaceutical Co., Ltd., approved by the National Medicines Agency H19993937, specific...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines and particularly relates to an application of acetytastragaloside in preparation of enterovirus inhibitors. The invention provides an application of the acetytastragaloside in preparation of medicines preventing and / or treating hand-foot-mouth disease. Experiments prove that the acetytastragaloside can inhibit cytopathic effects induced by enteroviruses, can increase the survival rate of virus-infected cells, can inhibit virus replication in vivo, can increase the survival rate of virus-infected animals, can prolong the survival time of the infected animals, and can relieve diseases caused by virus infection, and therefore the acetytastragaloside has a function of treating the hand-foot-mouth disease and application value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of acetyl astragaloside. Background technique [0002] Hand, foot and mouth disease is a childhood infectious disease caused by a virus, and it is a legal Class C infectious disease in my country. The disease mainly affects infants and young children aged 0-6, and children aged 2-3 are the most common infection. In the early stage of hand, foot and mouth disease, herpes or ulcers are caused on the extremities and mouth of children, and most children are within 1-2 weeks. get well. However, a small number of cases progress rapidly, and meningitis, aseptic encephalitis, brainstem encephalitis, encephalomyelitis, pulmonary edema, and circulatory disorders may occur within 1-5 days of onset. Death and sequelae may be left in surviving cases. [0003] According to the report of the World Health Organization, there are about 20 kinds of viruses that can cause sympto...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7048A61P31/12A61P31/14
CPCA61K31/7048
Inventor 萧伟丁玥曹泽彧曹亮王振中丁岗胡晗绯
Owner JIANGSU KANION PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com