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Chitosan-grafted resistant starch carrier material and its preparation method and use

A technology of anti-digestible starch and carrier materials, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, capsule delivery, etc. It can solve the problem of functional factor damage, functional factor controlled release carrier material and its controlled release delivery system, etc. problem, achieve the effect of improving bioavailability and achieving storage stability

Active Publication Date: 2017-02-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to ensure the effective function of food functional factors, it is necessary to take into account the damage of functional factors caused by the processing and storage process and the physiological environment of the human body, but the carrier materials developed by the current research do not take into account the compatibility of the two
At present, the preparation of functional factor controlled release carrier material and its controlled release delivery system by grafting chitosan and digestible starch has not been reported in China

Method used

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  • Chitosan-grafted resistant starch carrier material and its preparation method and use
  • Chitosan-grafted resistant starch carrier material and its preparation method and use
  • Chitosan-grafted resistant starch carrier material and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prepare 5 g of acetate-resistant digestible starch with a degree of substitution of 0.1 (refer to the specific preparation method: Journal of agricultural and food chemistry, 2011, 59(10): 5738-5745) and dissolve it in 95 g of dimethyl sulfoxide at 40°C for 20 min. Then transfer to the kneading reactor while stirring and add 5g of molecular weight 2.0×10 4 g / mol chitosan, add 5g potassium persulfate and 0.1g anhydrous sodium sulfite after 2min, then add 0.5g ceric ammonium nitrate and 0.05g N, N'-methylenebisacrylamide every 2min successively. After reacting at 40° C. for 15 min, the reaction was terminated by cooling, precipitated with ethanol and dried.

[0027]The prepared chitosan-grafted acetate anti-digestible starch is configured into a 4% coating solution with acetone, and it is uniformly sprayed on a 5- On the surface of ASA pellets, the acetate-resistant starch film-coated pellets grafted with chitosan were prepared. Table 1 shows the release performance of ...

Embodiment 2

[0031] Prepare 5 g of acetate-resistant digestible starch with a degree of substitution of 0.1 (refer to the specific preparation method: Journal of agricultural and food chemistry, 2011, 59(10): 5738-5745) and dissolve it in 7.5 g of dimethyl sulfoxide at 40°C for 40 min . Then transfer to the kneading reactor while stirring and add 5g of molecular weight 4.0×10 5 The chitosan of g / mol, add 5g potassium persulfate and 0.1g anhydrous sodium sulfite after 2min, then add 0.5g ammonium cerium nitrate successively every 2min, and 0.07gN, N'-methylenebisacrylamide. After reacting at 80° C. for 20 min, the reaction was terminated by cooling, precipitated with ethanol and dried.

[0032] The prepared chitosan-grafted acetate anti-digestible starch is configured into a 4% coating solution with acetone, and it is uniformly sprayed on a 5- On the surface of ASA pellets, the acetate-resistant starch film-coated pellets grafted with chitosan were obtained. Table 2 shows the release per...

Embodiment 3

[0036] Prepare 5 g of acetate-resistant digestible starch with a degree of substitution of 1.9 (refer to the specific preparation method: Journal of agricultural and food chemistry, 2011, 59(10):5738-5745) and dissolve it in 30 g of dimethyl sulfoxide at 60°C for 20 min. Then transfer to the kneading reactor while stirring and add 5g of molecular weight 2.0×10 4 The chitosan of g / mol, add 5g potassium persulfate and 0.1g anhydrous sodium sulfite after 5min, then add 0.5g ammonium cerium nitrate and 0.05g N, N'-methylenebisacrylamide successively every 5min. After reacting at 60° C. for 50 min, the reaction was terminated by cooling, precipitated with ethanol and dried.

[0037] The prepared chitosan-grafted acetate anti-digestible starch is configured into a 4% coating solution with acetone, and it is uniformly sprayed on a 5- On the surface of ASA pellets, the acetate-resistant starch film-coated pellets grafted with chitosan were prepared. Table 3 shows the comparison of t...

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Abstract

The invention discloses a chitosan-grafted resistant starch carrier material and its preparation method and use. The preparation method comprises dissolving acetate resistant starch with a substitution degree of 0.1-3.0 in an organic solvent at a temperature of 40-60 DEG C for 20-40min, adding chitosan in the solution along with stirring, orderly adding an initiator, an activator and a cross-linking agent into the mixed solution, carrying out a kneading reaction process at a temperature of 40-80 DEG C for 15-50min, cooling the products, depositing the products through ethanol and carrying out drying to obtain the chitosan-grafted resistant starch carrier material. Through appropriate control of carrier material coating thickness, an accumulative releasing rate of a functional factor in an upper digestive tract is less than or equal to 30% and a releasing rate of the functional factor in a simulative colon environment is 50% or more. The chitosan-grafted resistant starch carrier material realizes storage stability of the functional factor in a liquid food system and colon targeting controlled-release characteristics of the functional factor in the human digestive tract environment.

Description

technical field [0001] The present invention designs the research and development of natural polysaccharide materials in the field of controlled release of functional active substances, especially relates to a polysaccharide film-coated composite carrier material loaded with functional factors and the preservation mechanism of the polysaccharide film-coated composite carrier material in food and its Delivery system and controlled release of functional factors in the human body. Background technique [0002] Functional factors are the material basis of functional foods. By designing a targeted and controlled release delivery system for food functional factors, the processing and physiological barrier problems faced can be solved, and the functional factors can be prevented from being damaged due to processing and storage, especially in liquid food systems and human physiological environments. , so as to ensure the effective function of food. Carrier materials play an importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L3/06C08J3/24A61K47/36A61K9/50
CPCA61K47/36A61K9/5036C08J3/246C08L3/06C08L5/08C08J2305/08C08J2303/06C08L2203/16
Inventor 陈玲郑波李晓玺李琳
Owner SOUTH CHINA UNIV OF TECH