Method for improving bioactivity of block HA bio-material
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A biological material and bioactive technology, applied in the field of bioceramic material preparation, can solve problems such as poor mechanical properties, limit wide application, and reduced activity, and achieve the effects of low cost, easy industrialization, and promotion of regeneration
Inactive Publication Date: 2017-02-15
SHANGHAI UNIV
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However, the mechanical properties of HA materials are poor, and the high temperature during the preparation of
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[0024] Example 1:
[0025] In this example, see Figures 1 to 4 , a method for improving the biological activity of the biomaterial of bulk HA, comprising the steps of:
[0026] a. Prepare nano HA powder by precipitation method, put the nano HA powder in a drying box and completely dry it before use. The morphology of the nano HA powder is as follows figure 1 As shown, HA is hydroxyapatite;
[0027] b. Press molds for prefabricated bioceramic wafer samples, such as figure 2 Then, the nano-HA powder prepared in step a was flattened in the negative mold of the pressing mold, and the set load was applied to the mold with a microcomputer-controlled universal testing machine, and the HA block was pressed and formed, and then the HA block was pressed. The blank is out of the mold and ready for use;
[0028] c. sintering the HA block green body prepared in the step b at a high temperature of 1500°C, and then cooling with the furnace to decompose the hydroxyapatite in the HA bloc...
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[0031] Embodiment 2:
[0032] This embodiment is basically the same as the first embodiment, and the special features are:
[0033] In this comparative example, see image 3 , a method for improving the biological activity of a biomaterial of bulk HA, comprising the steps of:
[0034] A method for improving the biological activity of a biomaterial of bulk HA, comprising the steps of:
[0035] a. Prepare nano HA powder by precipitation method, put the nano HA powder in a drying box and completely dry it before use. The morphology of the nano HA powder is as follows figure 1 As shown, HA is hydroxyapatite;
[0036] b. Press molds for prefabricated bioceramic wafer samples, such as figure 2 Then, the nano-HA powder prepared in step a was flattened in the female mold of the pressing mold, and the set load was applied to the mold with a microcomputer-controlled universal testing machine, and the HA block was pressed and formed, and then the HA block was pressed. The blank is ...
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Abstract
The invention discloses a method for improving the bioactivity of a block HA bio-material. The method comprises the following steps: preparing HA nano-powder through a precipitating technology, spreading the HA nano-powder on a female die of a compacting die, and compacting the HA nano-powder through using a microcomputer controlled pressure in order to form an HA block; carrying out high temperature sintering on the HA block at a temperature not lower than 1500 DEG C, and cooling the sintered HA block with furnace in order to decompose the sintered HA block; and placing the decomposed HA block and NaHCO3 in a closed box, placing the closed box in a high temperature furnace, heating the closed box to a temperature not higher than 900 DEG C according to a rate not lower than 4 DEG C/min, keeping the temperature for 3 h, and cooling the obtained material with the furnace. The closed regeneration box is placed in the decomposed HA block, so high temperature volatilization of H2O is avoided; and NaHCO3 is placed in the closed box, and the closed box is heated from room temperature to the NaHCO3 decomposition temperature in order to decompose NaHCO3 and provide H2O with the weight 2 and 4 times the required weight of H2O in order to meet requirements of regeneration environment of the HA block. The method for improving bioactivity of block HA bio-material is a method for regenerating the HA block through introducing H2O required by regeneration to a closed space.
Description
technical field [0001] The invention relates to a method for preparing a biological material, in particular to a method for preparing a block of hydroxyapatite, which is applied in the technical field of bioceramic material preparation. Background technique [0002] Hydroxyapatite, referred to as HAP or HA, the molecular formula is Ca 10 (PO 4 ) 6 (OH) 2 , is a bioactive material. The density of HA is 3.16g / cm 3 , the Ca / P ratio is 1.67, and the elastic modulus is 3.6-21.0GPa, which is very similar to the composition and elastic modulus of human bone, and has good biocompatibility. After the HA material is implanted into the human body, under the action of body fluids, it will partially degrade, release calcium and phosphorus, and be absorbed and utilized by human tissues to grow new tissues, so that the biomaterials and human tissues implanted in the human body Good biocombination is obtained, so HA materials are usually used as ideal hard tissue replacement and repai...
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