Method for improving bioactivity of block HA bio-material

A biological material and bioactive technology, applied in the field of bioceramic material preparation, can solve problems such as poor mechanical properties, limit wide application, and reduced activity, and achieve the effects of low cost, easy industrialization, and promotion of regeneration

Inactive Publication Date: 2017-02-15

SHANGHAI UNIV

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AI-Extracted Technical Summary

Problems solved by technology

However, the mechanical properties of HA materials are poor, and the high temperature during the preparation of ...

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Method used

The present embodiment adopts airtight regeneration box to place the HA block after decomposing, avoids the high temperature volatilization of H O; And inserts NaHCO in airtight box, airtight box is heated to NaHCO from room temperature Decomposition temperatur...

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Abstract

The invention discloses a method for improving the bioactivity of a block HA bio-material. The method comprises the following steps: preparing HA nano-powder through a precipitating technology, spreading the HA nano-powder on a female die of a compacting die, and compacting the HA nano-powder through using a microcomputer controlled pressure in order to form an HA block; carrying out high temperature sintering on the HA block at a temperature not lower than 1500 DEG C, and cooling the sintered HA block with furnace in order to decompose the sintered HA block; and placing the decomposed HA block and NaHCO3 in a closed box, placing the closed box in a high temperature furnace, heating the closed box to a temperature not higher than 900 DEG C according to a rate not lower than 4 DEG C/min, keeping the temperature for 3 h, and cooling the obtained material with the furnace. The closed regeneration box is placed in the decomposed HA block, so high temperature volatilization of H2O is avoided; and NaHCO3 is placed in the closed box, and the closed box is heated from room temperature to the NaHCO3 decomposition temperature in order to decompose NaHCO3 and provide H2O with the weight 2 and 4 times the required weight of H2O in order to meet requirements of regeneration environment of the HA block. The method for improving bioactivity of block HA bio-material is a method for regenerating the HA block through introducing H2O required by regeneration to a closed space.

Application Domain

Tissue regenerationProsthesis

Technology Topic

DecompositionBiological materials +7

Image

Examples

Experimental program(2)
Comparison scheme(1)
Effect test(1)

Example Embodiment

[0024] Example 1:

[0025] In this example, see Figures 1 to 4 , a method for improving the biological activity of the biomaterial of bulk HA, comprising the steps of:

[0026] a. Prepare nano HA powder by precipitation method, put the nano HA powder in a drying box and completely dry it before use. The morphology of the nano HA powder is as follows figure 1 As shown, HA is hydroxyapatite;

[0027] b. Press molds for prefabricated bioceramic wafer samples, such as figure 2 Then, the nano-HA powder prepared in step a was flattened in the negative mold of the pressing mold, and the set load was applied to the mold with a microcomputer-controlled universal testing machine, and the HA block was pressed and formed, and then the HA block was pressed. The blank is out of the mold and ready for use;

[0028] c. sintering the HA block green body prepared in the step b at a high temperature of 1500°C, and then cooling with the furnace to decompose the hydroxyapatite in the HA block to prepare the HA block;

[0029] d. Combine the decomposed HA block and the set amount of NaHCO 3 They were placed in a closed box and placed in a high-temperature furnace, heated to 900 °C at a rate of 4 °C/min, then kept for 3 hours and then cooled in the furnace to obtain HA blocks regenerated from hydroxyapatite biomaterials.

[0030] In this example, a closed regeneration box is used to place the decomposed HA block to avoid H 2 High temperature volatilization of O; and put NaHCO in a closed box 3 , heat the airtight box from room temperature to NaHCO 3 Decomposition temperature, let NaHCO 3 Breaks down and provides H needed for 2x and 4x regeneration 2 O to meet the requirements of the HA block regenerating environment. Provide a way to regenerate the required H by introducing 2 A method for regenerating HA blocks.

Example Embodiment

[0031] Embodiment 2:

[0032] This embodiment is basically the same as the first embodiment, and the special features are:

[0033] In this comparative example, see image 3 , a method for improving the biological activity of a biomaterial of bulk HA, comprising the steps of:

[0034] A method for improving the biological activity of a biomaterial of bulk HA, comprising the steps of:

[0035] a. Prepare nano HA powder by precipitation method, put the nano HA powder in a drying box and completely dry it before use. The morphology of the nano HA powder is as follows figure 1 As shown, HA is hydroxyapatite;

[0036] b. Press molds for prefabricated bioceramic wafer samples, such as figure 2 Then, the nano-HA powder prepared in step a was flattened in the female mold of the pressing mold, and the set load was applied to the mold with a microcomputer-controlled universal testing machine, and the HA block was pressed and formed, and then the HA block was pressed. The blank is out of the mold and ready for use;

[0037] c. sintering the HA block green body prepared in the step b at a high temperature of 1500°C, and then cooling with the furnace to decompose the hydroxyapatite in the HA block to prepare the HA block;

[0038] d. Combine the decomposed HA block and the set amount of NaHCO 3 Put them together in a closed box, put them in a high-temperature furnace, heat them to 900°C at a rate of 4°C/min, then keep the temperature for 3 hours and then cool down with the furnace to obtain HA blocks prepared by the hydroxyapatite biomaterial regeneration process. body;

[0039] e. Repeat step d once, and finally obtain the HA block prepared by two hydroxyapatite biomaterial regeneration processes.

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Description & Claims & Application Information

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Exhaust after-treatment system with adjustable flow path, and method for operating such an exhaust after-treatment system

ActiveUS20200165953A1Facilitate mitigatingPromote regenerationGas treatmentInternal combustion piston enginesExhaust gasExhaust fumes

Owner:VOLVO LASTVAGNAR AB

Classification and recommendation of technical efficacy words

Promote regeneration
Improve method

Hydrogen peroxide working solution regenerant used in preparation of hydrogen peroxide process according to anthraquinone method and preparation method of hydrogen peroxide working solution regenerant

InactiveCN105152137APromote regenerationImprove stabilityPeroxides/peroxyhydrates/peroxyacids/superoxides/ozonidesChemical recyclingMagnesiumAnthraquinone process

Owner:XIANGTAN UNIV

Axon Regeneration Promoter

InactiveUS20070253946A1Promote regenerationEffectively regenerateBiocideNervous disorderAntisense nucleic acidDouble stranded

Owner:BIOCLUES

Method for improving bioactivity of block HA bio-material

A biological material and bioactive technology, applied in the field of bioceramic material preparation, can solve problems such as poor mechanical properties, limit wide application, and reduced activity, and achieve the effects of low cost, easy industrialization, and promotion of regeneration

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Image

Examples

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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