Metroprolol succinate sustained-release pellet and preparation method thereof
A technology of metoprolol succinate and sustained-release pellets, which is applied to a sustained-release preparation containing metoprolol succinate and its preparation, and the field of metoprolol succinate sustained-release pellets and its preparation, which can solve the problem of There are no commercialized products, difficult to obtain in large quantities, and no unified quality standards.
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Embodiment 1
[0039] Preparation of Metoprolol Succinate Sustained-Release Pellets
[0040] prescription:
[0041]
[0042]
[0043] *removed during process
[0044] Preparation Process:
[0045] 1) Dissolve metoprolol succinate and hypromellose in purified water, place the sucrose pellets in a fluidized bed, set the air inlet temperature to 50-70°C, and the air inlet volume to 70-120m 3 / h, atomization pressure 1.5~2.5bar, spray speed 6~20g / min. After the coating liquid is sprayed, keep the air inlet temperature and dry for 0.5 to 2 hours to obtain pellet A1.
[0046] 2) Dissolve ethyl cellulose and hydroxypropyl cellulose in ethanol, place the pellets A1 prepared in the previous step in a fluidized bed, set the air inlet temperature to 40-50°C, and the air inlet volume to 70-120m 3 / h, atomization pressure 1.5~2.5bar, spray speed 3~16g / min. After the coating liquid is sprayed, keep the air inlet temperature and dry for 0.5 to 2 hours to obtain pellets B1.
[0047] 3) Put the...
Embodiment 2
[0055] Preparation of Metoprolol Succinate Sustained-Release Pellets
[0056] prescription:
[0057]
[0058]
[0059] *removed during process
[0060] Preparation Process:
[0061] 1) Dissolve metoprolol succinate and polyvinylpyrrolidone in acetone, place the sucrose pellets in a fluidized bed, set the inlet air temperature to 40-60 °C, the air inlet volume to 70 to 120 m3 / h, and the atomization pressure to 1.5 ~2.5bar, spray speed 6~20g / min. After the coating liquid is sprayed, keep the inlet air temperature and dry for 0.5-2 hours to obtain pellet A2.
[0062] 2) Dissolve ethyl cellulose and hypromellose in methylene chloride, place the pellets A2 prepared in the previous step in a fluidized bed, set an inlet air temperature of 35 to 50 °C, and an inlet air volume of 70 to 120 m3 / h, atomization pressure 1.5~2.5bar, spray speed 3~16g / min. After the coating liquid is sprayed, keep the inlet air temperature and dry for 0.5 to 2 hours to obtain pellets B2.
[00...
Embodiment 3
[0070] Preparation of Metoprolol Succinate Sustained-Release Pellets
[0071] prescription:
[0072]
[0073] *removed during process
[0074] Preparation Process:
[0075] 1) Dissolve metoprolol succinate and hydroxypropyl cellulose in ethanol, place the sucrose pellets in a fluidized bed, set the inlet air temperature to 40-60°C, and set the inlet air volume to 70-120m 3 / h, atomization pressure 1.5~2.5bar, spray speed 6~20g / min. After the coating liquid is sprayed, keep the inlet air temperature and dry for 0.5 to 2 hours to obtain pellet A3.
[0076] 2) Dissolve ethyl cellulose and polyethylene glycol in acetone, place the pellets A3 prepared in the previous step in a fluidized bed, set an inlet air temperature of 35 to 50 °C, and an inlet air volume of 70 to 120 m3 / h, The atomization pressure is 1.5~2.5bar, and the spraying speed is 3~16g / min. After the coating liquid is sprayed, keep the air inlet temperature and dry for 0.5 to 2 hours to obtain pellets B3.
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