44results about How to "Easy to achieve industrial scale-up" patented technology

The invention provides a solid base catalyst for synthesizing dimethyl carbonate through a transesterification method. The components are Ca-Al-O-X, wherein the mole content of Ca ranges from 15% to 35%, the mole content of Al ranges from 5% to 30%, the mole content of X ranges from 0.1% to 10%, the balance is O, and X is CO3<2-> or NO3<-> or F<-> or Cl<-> or Br<->. The solid base catalyst has the advantages that the use temperature is low, the conversion rate of propylene carbonate under the low-temperature condition is high, and the yield of dimethyl carbonate is high.

The invention discloses a catalyst for synthesizing methanol through CO2 hydrogenation, comprising Cu, Zn, Al, X, halogen and oxygen elements, oxides and halides, wherein the molar ratio of [Cu+Zn+MA] to [Al+Mb] is 2-18; the molar ratio of Cu to Zn is 0.5-5; the molar ratio of MA to [Cu+Zn] is 0-5; the molar ratio of MB to Al is 0-9; the molar ratio of halogen to Al is 0.05-5; MA and MB cannot be 0 at the same time; MA represents a mono-valent or divalent metal ion in X; MB represents a trivalent and / or tetravalent metal ion in X; X is one or a combination of more elements of Li, K, Mg, B, Ga, In, transition metal elements and rare-earth metal elements. The catalyst has the advantages of high carbon dioxide conversion rate, good methanol selectivity and high methanol yield.

The invention discloses a method for preparing mettriptin, specifically, the mettriptin gene is expressed through a prokaryotic expression system to obtain inclusion bodies, the inclusion bodies are dissolved, and hydrophobic chromatography renaturation is performed to obtain mettriptin protein. Both inclusion body solubilization and hydrophobic chromatographic renaturation are carried out in a gentle manner, and antioxidants and / or metal chelating agents can also be added during the process to inhibit the oxidation and degradation of the target protein. The method for preparing mettriptin is easy to realize industrial scale-up, high renaturation efficiency, high yield and good biological activity.

The invention discloses a gas-liquid-solid three-phase counter-current reaction device and a gas-liquid-solid three-phase counter-current reaction method for pyrolytic reaction of carbamic acid ester, and belongs to the technical field of pyrolytic reaction of carbamic acid ester. The reaction device comprises a reactor, a carrier gas preheating part, a feeding part, a product collecting part, a byproduct collecting and condensing part, a gas outlet and a feed liquid outlet. The upper part of the reactor is provided with a feed liquid inlet, the bottom of the reactor is provided with a gas inlet, and gas and liquid in the reactor are in counter-current contact so as to form a gas-liquid-solid three-phase counter-current reactor; carrier gas is preheated by the preheater, and enters the reactor through the gas inlet; the reaction feed liquid is preheated in the feeding part, and enters the reactor through the feed liquid inlet; in the reactor, the reaction feed li quid and the carrier gas are in counter-current contact fully, heat is transferred by a heat carrier, and the pyrolytic reaction is carried out; the carrier gas brings byproducts alcohols out from the gas outlet on the upper part of the reactor, and the reaction feed liquid is moved through the feed liquid outlet on the bottom of the reactor; and the byproduct collecting and condensing part collects, condenses and recovers the byproducts alcohols. The device and the method have the advantages of quick heat and mass transfer of gas, liquid and solid.

The invention discloses a preparation method of high pure crocin and geniposide. The preparation method comprises following main steps: selecting raw materials of gardenia ellis plants, extracting with water or an alcohol-water mixed solution, merging the extracting solutions, condensing, filtering, subjecting the obtained extracting solution to an adsorption treatment by macroporous resin, then performing gradient elution with a ethanol-water mixed solution, obtaining geniposide and gardenia yellow refined extracts; subjecting the geniposide refined extract to a recrystallization treatment with ethyl acetate so as to obtain the geniposide product; subjecting the gardenia yellow refined extract to go through column chromatography, which has been pressurized and stuffed with modified silica gel, to separate, and obtaining the high pure crocin product (color value larger than 600) and a chlorogenic acid component. The products have the advantages of high purity, simple technology, strong operability and convenience for automation, comprehensive utilization of the plant resources is achieved, the solvent is convenient to recycle and reuse, and the preparation method is easy to apply to the industrial amplification.

The invention relates to a technological process for extracting aucubin from fruits of eucommia ulmoides oliver, which comprises the following steps: cutting the fruits of the eucommia ulmoides oliver into pieces, extracting with water or ethanol solution as an extraction solvent, and purifying the obtained extracting solution with macroporous resin to obtain the aucubin the purity of which is more than 50%. The technological process has the advantages of low toxicity, safety, short process time, no environmental pollution, simple and convenient operation, easy industrialization enlargement, high yield and good purity of the product, thus meeting various needs for development of drugs taking the fruits of the eucommia ulmoides oliver as main raw materials.

The invention relates to a pervaporation blend membrane for separating a mixture methanol and tetrahydrofuran and a preparation method of permeation vaporization blend membrane. The pervaporation membrane with a uniform and compact structure is prepared by virtue of a blending method by adopting P84 polyimide and cellulose acetate as basic raw materials. The pervaporation blend membrane has the beneficial effects that the blend membrane gives priority to the permeation of methanol and can separate the methanol and tetrahydrofuran mixture and purify the tetrahydrofuran; the pervaporation method adopted to separate the methanol-tetrahydrofuran mixture has the advantages of high separation efficiency, simple equipment, low energy consumption, no pollution and the like; and the blend membrane is excellent in separation performance and high in chemical stability, the materials for preparing the membrane is conventional, easy to get and low in price, and the industrialized production is facilitated.