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Technological process for extracting aucubin from fruits of eucommia ulmoides oliver

A kind of aucubin, the technology of the process method, which is applied in the directions of chemical instruments and methods, pharmaceutical formulations, non-central pain relievers, etc., can solve the problems such as insufficient utilization of Eucommia ulmoides, unfavorable large-scale production operations, complicated preparation process, etc. Easy to scale up for industrialization, low cost, good purity

Inactive Publication Date: 2013-02-13
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research of this plant focuses on the medicinal value of lignans and chlorogenic acid compounds in Eucommia bark and Eucommia leaves, but the utilization of Eucommia fruit is not much, resulting in a waste of resources
According to the applicant's retrieval, the existing Eucommia fruit patents are all related to Eucommia ulmoides seed oil, and there is another related journal paper on extracting aucubin from Eucommia ulmoides fruit (Peng Mijun, Yin Dazhong, Liu Liping, etc. Peach leaves in Eucommia seed meal Preparation of coralline. Fine Chemical Industry, 2007, 24(3): 243-247), the paper adopts microwave method and reversed-phase preparative chromatographic technology to prepare, this process cost is very high, the preparation process is cumbersome, and it is not conducive to large-scale production operation

Method used

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  • Technological process for extracting aucubin from fruits of eucommia ulmoides oliver
  • Technological process for extracting aucubin from fruits of eucommia ulmoides oliver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 1 kg of eucommia fruit medicinal material, cut the fruit into 3 to 4 sections with a guillotine, add 6L of water, soak for 3 hours, reflux for 2 hours, filter; add 5L of water to the dregs, reflux for 2 hours, filter, and use the same method for the dregs Extract 1 time, combine the filtrate, concentrate until the medicinal liquid volume and medicinal material mass ratio are 2: 1, add to the good NKA-9 type (Tianjin Nankai Hecheng Technology Co., Ltd.) macroporous adsorption resin column (resin bed volume About 2.3L (equivalent to the weight ratio of resin to medicinal material is 1.5:1), first use 3 times the resin bed volume (3BV) water to elute until almost colorless, discard the eluent, and then use 80% Elute with ethanol aqueous solution, collect one part per 600ml, collect 15 parts (equivalent to about 4BV), test, combine 6 to 13 parts of eluent according to the test results, recover ethanol under reduced pressure at 60°C, and spray dry to obtain Eucommia frui...

Embodiment 2

[0024] Take 5 kg of eucommia fruit medicinal material, cut the fruit into 3 to 4 sections with a guillotine, add 30 L of 50% ethanol aqueous solution, soak for 3 hours, reflux extraction for 2 hours, filter; add 25 L of 50% ethanol aqueous solution to the dregs, and reflux extraction for 2 hours, Filter, and extract the medicinal residues once more in the same way, combine the filtrates, concentrate until the volume of the medicinal liquid and the mass ratio of the medicinal materials are 2:1, add to the treated S-8 type (Tianjin Nankai Hecheng Technology Co., Ltd.) Porous adsorption resin column (resin bed volume is about 15L, equivalent to the weight ratio of resin to medicinal material is 5:1), first eluted with water 3 times the resin bed volume (3BV) until it is almost colorless, discard the eluted solution, and then eluted with 60% ethanol aqueous solution, collected one part per 4000ml, collected 15 parts (equivalent to about 4BV), detected, combined 7 to 11 parts of elu...

Embodiment 3

[0026] Take 10kg of eucommia fruit medicinal material, cut the fruit into 3-4 sections with a guillotine, add 60L of 10% ethanol aqueous solution, soak for 3 hours, reflux for 2 hours, filter; add 50L of water to the dregs, reflux for 2 hours, filter, dregs Extract once again with the same method, combine the filtrates, concentrate until the volume of the medicinal liquid and the mass ratio of the medicinal materials are 2: 1, add to the D301R type (Tianjin Nankai Hecheng Technology Co., Ltd.) macroporous adsorption resin column (resin The bed volume is about 36L, which is equivalent to the weight ratio of the resin to the medicinal material being 3:1). First, use 3 times the volume of the resin bed volume (3BV) to elute until almost colorless, discard the eluent, and then use 50% Elution with ethanol aqueous solution, collect one part per 8000ml, collect 18 parts (equivalent to about 4BV), test, combine 5-10 parts of eluent according to the test results, recover ethanol under ...

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Abstract

The invention relates to a technological process for extracting aucubin from fruits of eucommia ulmoides oliver, which comprises the following steps: cutting the fruits of the eucommia ulmoides oliver into pieces, extracting with water or ethanol solution as an extraction solvent, and purifying the obtained extracting solution with macroporous resin to obtain the aucubin the purity of which is more than 50%. The technological process has the advantages of low toxicity, safety, short process time, no environmental pollution, simple and convenient operation, easy industrialization enlargement, high yield and good purity of the product, thus meeting various needs for development of drugs taking the fruits of the eucommia ulmoides oliver as main raw materials.

Description

【Technical field】 [0001] The invention relates to a method for extracting and separating effective plant components in the pharmaceutical industry, in particular to a process for extracting aucubin from Eucommia ulmoides. 【Background technique】 [0002] Aucubin (aucubin) belongs to iridoid glycosides with molecular formula C 15 h 22 o 9 , molecular weight 346.331, CAS No. 479-98-1, melting point 181°C, easily soluble in water, ethanol and methanol, almost insoluble in chloroform, ether and petroleum ether. This compound mainly exists in plants such as Eucommia ulmoides Oliver, Aucubachinensis Benth., Plantago asiatica L., etc. Liver protection and detoxification, anti-inflammatory, anti-oxidation, anti-aging, anti-osteoporosis and nutrition neuron cells and many other pharmacological activities. The structural formula of aucubin is as follows: [0003] [0004] Eucommia ulmoides is the fruit of Eucommia ulmoides Oliver, a single species of Eucommia ulmoides Oliver in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61K36/46A61P1/16A61P39/02A61P29/00A61P39/06A61P19/10A61P25/00A61K131/00
Inventor 刘玉明陈宝泉李彩文
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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