Technological process for extracting aucubin from fruits of eucommia ulmoides oliver
A kind of aucubinin and process method technology, applied in the directions of chemical instruments and methods, pharmaceutical formulations, non-central pain relievers, etc., can solve the problems such as insufficient utilization of Eucommia ulmoides, unfavorable large-scale production operations, cumbersome preparation process, etc. Easy to scale up for industrialization, low cost, good purity
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Embodiment 1
[0022] Take 1 kg of eucommia fruit medicinal material, cut the fruit into 3 to 4 sections with a guillotine, add 6L of water, soak for 3 hours, reflux for 2 hours, filter; add 5L of water to the dregs, reflux for 2 hours, filter, and use the same method for the dregs Extract 1 time, combine the filtrate, concentrate until the medicinal liquid volume and medicinal material mass ratio are 2: 1, add to the good NKA-9 type (Tianjin Nankai Hecheng Technology Co., Ltd.) macroporous adsorption resin column (resin bed volume About 2.3L (equivalent to the weight ratio of resin to medicinal material is 1.5:1), first use 3 times the resin bed volume (3BV) water to elute until almost colorless, discard the eluent, and then use 80% Elute with ethanol aqueous solution, collect one part per 600ml, collect 15 parts (equivalent to about 4BV), test, combine 6 to 13 parts of eluent according to the test results, recover ethanol under reduced pressure at 60°C, and spray dry to obtain Eucommia frui...
Embodiment 2
[0024] Take 5 kg of eucommia fruit medicinal material, cut the fruit into 3 to 4 sections with a guillotine, add 30 L of 50% ethanol aqueous solution, soak for 3 hours, reflux extraction for 2 hours, filter; add 25 L of 50% ethanol aqueous solution to the dregs, and reflux extraction for 2 hours, Filter, and extract the medicinal residues once more in the same way, combine the filtrates, concentrate until the volume of the medicinal liquid and the mass ratio of the medicinal materials are 2:1, add to the treated S-8 type (Tianjin Nankai Hecheng Technology Co., Ltd.) Porous adsorption resin column (resin bed volume is about 15L, equivalent to the weight ratio of resin to medicinal material is 5:1), first eluted with water 3 times the resin bed volume (3BV) until it is almost colorless, discard the eluted solution, and then eluted with 60% ethanol aqueous solution, collected one part per 4000ml, collected 15 parts (equivalent to about 4BV), detected, combined 7 to 11 parts of elu...
Embodiment 3
[0026] Take 10kg of eucommia fruit medicinal material, cut the fruit into 3-4 sections with a guillotine, add 60L of 10% ethanol aqueous solution, soak for 3 hours, reflux for 2 hours, filter; add 50L of water to the dregs, reflux for 2 hours, filter, dregs Extract once again with the same method, combine the filtrates, concentrate until the volume of the medicinal liquid and the mass ratio of the medicinal materials are 2: 1, add to the D301R type (Tianjin Nankai Hecheng Technology Co., Ltd.) macroporous adsorption resin column (resin The bed volume is about 36L, which is equivalent to the weight ratio of the resin to the medicinal material being 3:1). First, use 3 times the volume of the resin bed volume (3BV) to elute until almost colorless, discard the eluent, and then use 50% Elution with ethanol aqueous solution, collect one part per 8000ml, collect 18 parts (equivalent to about 4BV), test, combine 5-10 parts of eluent according to the test results, recover ethanol under ...
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